Filtered By:
Condition: Hypertension
Nutrition: Calcium
This page shows you your search results in order of date.
Order by Relevance | Date
Total 24 results found since Jan 2013.
Orai1 Inhibitors as Potential Treatments for Pulmonary Arterial Hypertension
CONCLUSIONS: In human PAH and experimental PH, Orai1 expression and activity are increased. Orai1 inhibition normalizes the PAH-hPASMCs phenotype and attenuates PH in rat models. These results suggest that Orai1 should be considered as a relevant therapeutic target for PAH.PMID:36164973 | DOI:10.1161/CIRCRESAHA.122.321041
Source: Circulation Research - September 27, 2022 Category: Cardiology Authors: Bastien Masson H élène Le Ribeuz Jessica Sabourin Loann Laubry Emily Woodhouse Richard Foster Yann Ruchon Mary Dutheil Ang èle Boët Maria-Rosa Ghigna Vincent De Montpreville Olaf Mercier David J Beech Jean-Pierre Benitah Marc A Bailey Marc Humbert Dav Source Type: research
Loss of lung microvascular endothelial Piezo2 expression impairs NO synthesis, induces EndMT and is associated with pulmonary hypertension
Am J Physiol Heart Circ Physiol. 2022 Sep 23. doi: 10.1152/ajpheart.00220.2022. Online ahead of print.ABSTRACTMechanical forces are translated into biochemical stimuli by mechanotransduction channels, such as the mechanically-activated cation channel Piezo2. Lung Piezo2 expression has recently been shown to be restricted to endothelial cells. Hence, we aimed to investigate the role of Piezo2 in regulation of pulmonary vascular function and structure as well as its contribution to development of pulmonary arterial hypertension (PAH). The expression of Piezo2 was significantly reduced in pulmonary microvascular endothelial c...
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 23, 2022 Category: Physiology Authors: Siyu Tian Zongye Cai Payel Sen Denise van Uden Esther van de Kamp Raphael Thuillet Ly Tu Christophe Guignabert Karin Boomars Kim Van der Heiden Maarten M Brandt Daphne Merkus Source Type: research
SKF96365 activates calcium-sensing receptors in pulmonary arterial smooth muscle cells
Biochem Biophys Res Commun. 2022 Mar 25;607:44-48. doi: 10.1016/j.bbrc.2022.03.121. Online ahead of print.ABSTRACTIn pulmonary arterial smooth muscle cells (PASMCs), an increase in the cytosolic Ca2+ concentration ([Ca2+]cyt) is involved in many physiological processes such as cell contraction and proliferation. However, chronic [Ca2+]cyt increases cause pulmonary vasoconstriction and vascular remodeling, resulting in pulmonary arterial hypertension (PAH). Therefore, [Ca2+]cyt signaling plays a substantial role in the regulation of physiological and pathological functions in PASMCs. In the present study, the effects of SKF...
Source: Cell Research - April 2, 2022 Category: Cytology Authors: Riko Miyaki Aya Yamamura Akiko Kawade Moe Fujiwara Rubii Kondo Yoshiaki Suzuki Hisao Yamamura Source Type: research
