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Condition: Pulmonary Hypertension
Nutrition: Calcium

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Total 16 results found since Jan 2013.

Orai1 Inhibitors as Potential Treatments for Pulmonary Arterial Hypertension
CONCLUSIONS: In human PAH and experimental PH, Orai1 expression and activity are increased. Orai1 inhibition normalizes the PAH-hPASMCs phenotype and attenuates PH in rat models. These results suggest that Orai1 should be considered as a relevant therapeutic target for PAH.PMID:36164973 | DOI:10.1161/CIRCRESAHA.122.321041
Source: Circulation Research - September 27, 2022 Category: Cardiology Authors: Bastien Masson H élène Le Ribeuz Jessica Sabourin Loann Laubry Emily Woodhouse Richard Foster Yann Ruchon Mary Dutheil Ang èle Boët Maria-Rosa Ghigna Vincent De Montpreville Olaf Mercier David J Beech Jean-Pierre Benitah Marc A Bailey Marc Humbert Dav Source Type: research

Loss of lung microvascular endothelial Piezo2 expression impairs NO synthesis, induces EndMT and is associated with pulmonary hypertension
Am J Physiol Heart Circ Physiol. 2022 Sep 23. doi: 10.1152/ajpheart.00220.2022. Online ahead of print.ABSTRACTMechanical forces are translated into biochemical stimuli by mechanotransduction channels, such as the mechanically-activated cation channel Piezo2. Lung Piezo2 expression has recently been shown to be restricted to endothelial cells. Hence, we aimed to investigate the role of Piezo2 in regulation of pulmonary vascular function and structure as well as its contribution to development of pulmonary arterial hypertension (PAH). The expression of Piezo2 was significantly reduced in pulmonary microvascular endothelial c...
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 23, 2022 Category: Physiology Authors: Siyu Tian Zongye Cai Payel Sen Denise van Uden Esther van de Kamp Raphael Thuillet Ly Tu Christophe Guignabert Karin Boomars Kim Van der Heiden Maarten M Brandt Daphne Merkus Source Type: research

TRPV4 channel mediates adventitial fibroblast activation and adventitial remodeling in pulmonary hypertension.
Abstract Pulmonary arterial adventitial fibroblasts (PAF), the most abundant cellular constituent of adventitia, act as a key regulator of pulmonary vascular wall structure and function from the outside-in. Previous studies indicate that Transient Receptor Potential Vanilloid 4 (TRPV4) channel plays an important role in the development of pulmonary hypertension (PH), but no attention has been given so far to its role in adventitial remodeling. In the present study, we thus investigated TRPV4 implication in PAF activation occurring in PH. First, we isolated and cultured PAF from rat adventitial intrapulmonary arter...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - November 5, 2019 Category: Cytology Authors: Cussac LA, Cardouat G, Tiruchellvam Pillai N, Campagnac M, Robillard P, Montillaud A, Guibert C, Gailly P, Marthan R, Quignard JF, Savineau JP, Ducret T Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Late Breaking Abstract - Chronic Hypoxia Promotes Pulmonary Venous Smooth Muscle Cells Proliferation by Upregulating Calcium Sensing Receptor
Conclusions: CaSR mediating excessive PVSMC proliferation is a new pathogenic mechanism involved in the initiation and progression of hypoxic PVSMC proliferation.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Peng, G., Li, S., Hong, W., Xu, J., Liu, R., Li, B., Ran, P. Tags: Pulmonary hypertension Source Type: research