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The crosstalk between TLR2 and NOD2 in Aspergillus fumigatus keratitis
Publication date: April 2015 Source:Molecular Immunology, Volume 64, Issue 2 Author(s): Jiayin Wu , Yuting Zhang , Zhaoting Xin , Xinyi Wu Innate immunity is considered to be critical in the pathogenesis of fungal keratitis. Pattern recognition receptors (PRRs) recognize conserved microbial structures called pathogen-associated molecular patterns (PAMPS), thereby initiating the innate immunity. Toll-like receptors (TLRs) and nucleotide-binding oligomerization domain (NOD)-like receptors (leucine-rich repeat-containing receptors, NLRs) are two major PRR families. The crosstalk between TLR2 and NOD2 is not completely under...
Source: Molecular Immunology - January 1, 2015 Category: Allergy & Immunology Source Type: research

Phosphoinositide 3-kinase {delta} signaling modulates endoplasmic reticulum stress in aspergillus fumigatus-induced allergic lung inflammation
In this study, we aimed to elucidate an association of ER stress with PI3K- signaling in fungus-induced allergic lung inflammation.Using Aspergillus fumigatus-exposed in vivo and in vitro experimental systems, we have investigated the role of PI3K- in the regulation of ER stress in the pathogenesis of allergic lung inflammation.The Aspergillus fumigatus-sensitized and -challenged mice showed that the expression of ER stress markers and the protein levels of unfolded protein response (UPR)-related markers in lung tissues were significantly increased after Aspergillus fumigatus challenge. Protein expression of ER stress mark...
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Lee, Y. C., Kim, S. R., Lee, K. S., Ko, Y. H., Jeong, J. S. Tags: 5.3 Allergy and Immunology Source Type: research

Functional role of protein kinase D1 in Aspergillums fumigates-induced activation of nuclear factor-κB signal pathway and transcription.
CONCLUSION: PKD1 may contribute to the activation of NF-κB signal pathway and NF-κB transcription induced by Aspergillums fumigates. PMID: 23529230 [PubMed - in process]
Source: Journal of Southern Medical University - March 1, 2013 Category: Universities & Medical Training Authors: Niu X, Xu W, Li S, Ke Z, Zeng F, Luo S, Deng F Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research

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