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Alternaria Induces Production of Thymic Stromal Lymphopoietin in Nasal Fibroblasts Through Toll-like Receptor 2.
CONCLUSIONS: The results of this study show that TSLP expression could be induced in nasal fibroblasts by exposure to Alternaria and that TLR2 may be involved in the process. The promotion of TSLP production in nasal fibroblasts by airborne fungi may facilitate the development or exacerbation of Th2-type nasal inflammation, especially in CRS with nasal polyps. PMID: 26540503 [PubMed]
Source: Allergy, Asthma and Immunology Research - November 7, 2015 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research

NLRP3 inflammasome is activated via phosphoinositide 3-kinase {delta} pathway in Aspergillus fumigatus-induced allergic airway inflammation
In this study, we focused on an association of NLRP3 inflammasome activation with PI3K- signaling in Aspergillus fumigatus (Af)-induced allergic lung inflammation. Using Af-exposed in vivo and in vitro experimental systems, we have investigated the role of PI3K- in the regulation of NLRP3 inflammasome activation in the pathogenesis of fungus-induced allergic lung inflammation.The protein expression of NLRP3, caspase-1, and IL-1bin lungs was significantly increased after the challenge in Af-sensitized and -challenged mice. Protein expression of NLRP3 and caspase-1 was also remarkably elevated in Af-stimulated cultured trach...
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Lee, Y. C., Kim, S. R., Lee, K. B., Park, H. J., Jeong, J. S. Tags: 5.3 Allergy and Immunology Source Type: research

Phosphoinositide 3-kinase {delta} signaling modulates endoplasmic reticulum stress in aspergillus fumigatus-induced allergic lung inflammation
In this study, we aimed to elucidate an association of ER stress with PI3K- signaling in fungus-induced allergic lung inflammation.Using Aspergillus fumigatus-exposed in vivo and in vitro experimental systems, we have investigated the role of PI3K- in the regulation of ER stress in the pathogenesis of allergic lung inflammation.The Aspergillus fumigatus-sensitized and -challenged mice showed that the expression of ER stress markers and the protein levels of unfolded protein response (UPR)-related markers in lung tissues were significantly increased after Aspergillus fumigatus challenge. Protein expression of ER stress mark...
Source: European Respiratory Journal - December 23, 2014 Category: Respiratory Medicine Authors: Lee, Y. C., Kim, S. R., Lee, K. S., Ko, Y. H., Jeong, J. S. Tags: 5.3 Allergy and Immunology Source Type: research