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Source: Molecular Medicine Reports
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Total 308 results found since Jan 2013.
Downregulation of caveolin‑1 upregulates the expression of growth factors and regulators in co‑culture of fibroblasts with cancer cells.
Authors: Shi XY, Xiong LX, Xiao L, Meng C, Qi GY, Li WL
Abstract
Reduced expression levels of caveolin‑1 (Cav‑1) in tumor stromal fibroblasts influences the occurrence and progression of tumors, particularly in breast cancer, but the relevant molecular mechanism is unclear. The present study aimed to clarify the potential mechanism underlying the promotion of tumor growth by reduced Cav‑1 expression levels, by investigating Cav‑1‑targeted molecules in fibroblasts and breast cancer cells. The expression of growth factors in the ESF fibroblast cell line transfected with Cav‑1 small interfering RNA (siRNA...
Source: Molecular Medicine Reports - December 11, 2015 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Flap endonuclease 1 silencing is associated with increasing the cisplatin sensitivity of SGC‑7901 gastric cancer cells.
Authors: Xie C, Wang K, Chen D
Abstract
Flap endonuclease 1 (FEN1), which is key in DNA replication and repair, has been demonstrated to be intimately involved in the development and progression of cancer. Our previous study determined that the downregulation of FEN1 can suppress the proliferation of, and induce apoptosis in, gastric cancer SGC‑7901 cells. In addition, several FEN1 inhibitors have been identified to increase sensitisation to DNA injury agents. These results may provide a promising treatment method to enhance the traditional chemotherapeutics used for the treatment of gastric cancer. Thus, the aim...
Source: Molecular Medicine Reports - January 16, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Downregulation of fatty acid synthase complex suppresses cell migration by targeting phospho‑AKT in bladder cancer.
Authors: Zheng SS, Gao JG, Liu ZJ, Zhang XH, Wu S, Weng BW, Wang YL, Hou SC, Jiang B
Abstract
The aim of the present study was to investigate the effect of fatty acid synthase complex (FASN) on the migration capacity of bladder transitional cell carcinoma (BTCC) cells and the involvement of matrix metalloproteinase‑9 (MMP‑9) via targeting of phospho‑AKT (p‑AKT). FASN‑specific small‑interfering RNA (FASN‑siRNA) was used to inhibit FASN gene expression in the 5637 and 253J BTCC cell lines. The knockdown efficiency of FAM‑conjugated FASN‑siRNA was confirmed by fluorescence microscopy. The migratory a...
Source: Molecular Medicine Reports - January 16, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Rab5a ‑mediated autophagy regulates the phenotype and behavior of vascular smooth muscle cells.
Rab5a‑mediated autophagy regulates the phenotype and behavior of vascular smooth muscle cells.
Mol Med Rep. 2016 Sep 26;
Authors: Tan JY, Jia LQ, Shi WH, He Q, Zhu L, Yu B
Abstract
Rab5a, a key member of the Rab family of GTPases, was determined to be a regulator of vascular smooth muscle cell (VSMC) proliferation and migration. However, the exact regulatory mechanism remains unclear. As Rab5a has been shown to be associated with autophagy, which is essential for the conversion of VSMCs from a contractile to a synthetic phenotype in order to prevent cell death due to oxidative stress. The present stu...
Source: Molecular Medicine Reports - September 27, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Glycogen synthase kinase ‑3β is required for epithelial‑mesenchymal transition and barrier dysfunction in mouse podocytes under high glucose conditions.
In conclusion, the present study determined that GSK‑3β is required for EMT and barrier dysfunction in podocytes under HG conditions; therefore, GSK‑3β may be a novel target for the treatment of DN.
PMID: 27748847 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - October 18, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
MicroRNA ‑21 promotes migration and invasion of glioma cells via activation of Sox2 and β‑catenin signaling.
MicroRNA‑21 promotes migration and invasion of glioma cells via activation of Sox2 and β‑catenin signaling.
Mol Med Rep. 2016 Nov 28;:
Authors: Luo G, Luo W, Sun X, Lin J, Wang M, Zhang Y, Luo W, Zhang Y
Abstract
The expression of microRNA 21 (miR-21) has been reported to be upregulated in various types of cancer, including malignant gliomas. However, its functions and mechanisms in glioma remain to be fully elucidated. The present study established miRNA‑21 overexpression and knockdown cell lines using SRY‑box 2 (Sox2) small interfering RNA (siRNA) to knockdown expression and Sox2 cDNA was ...
Source: Molecular Medicine Reports - December 3, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Reduced expression of miR ‑205‑5p promotes apoptosis and inhibits proliferation and invasion in lung cancer A549 cells by upregulation of ZEB2 and downregulation of erbB3.
Reduced expression of miR‑205‑5p promotes apoptosis and inhibits proliferation and invasion in lung cancer A549 cells by upregulation of ZEB2 and downregulation of erbB3.
Mol Med Rep. 2017 Mar 28;:
Authors: Jiang M, Zhong T, Zhang W, Xiao Z, Hu G, Zhou H, Kuang H
Abstract
Previous studies have demonstrated that microRNA (miR)-205-5p expression is significantly increased in non‑small cell lung cancer tissues and is associated with tumor differentiation grade. The aim of the present study was to explore the effects of miR‑205‑5p on viability, apoptosis and invasion of lung cancer A549 cells. Th...
Source: Molecular Medicine Reports - March 31, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
E ‑cadherin involvement in human lens epithelial cell transdifferentiation may be associated with N‑cadherin.
E‑cadherin involvement in human lens epithelial cell transdifferentiation may be associated with N‑cadherin.
Mol Med Rep. 2017 Aug 02;:
Authors: Huang L, Jiang J, Guo Q, Yang H
Abstract
E-cadherin, β-catenin and N‑cadherin serve key roles in the epithelial‑to‑mesenchymal transition (EMT) that leads to human lens epithelial cell (LEC) transdifferentiation and subsequent cataract formation. The present study aimed to investigate the role of E‑cadherin in LEC transdifferentiation. SRA01/04 human LECs were transfected with E‑cadherin short interfering (si)RNA (E‑cadherin siRNA group), nega...
Source: Molecular Medicine Reports - August 4, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Munc13 ‑4 mediates human neutrophil elastase‑induced airway mucin5AC hypersecretion by interacting with syntaxin2.
Munc13‑4 mediates human neutrophil elastase‑induced airway mucin5AC hypersecretion by interacting with syntaxin2.
Mol Med Rep. 2018 May 14;:
Authors: Xu R, Zhou J, Zhou XD, Li Q, Perelman JM, Kolosov VP
Abstract
The overexpression and hypersecretion of mucus is a hallmark of chronic pulmonary inflammatory disease. Mucin5AC (MUC5AC) is a major component of airway gel‑forming mucin. Members of the Unc13 (Munc13) protein family act as important activators of granule exocytosis from various types of mammalian cells. The present study aimed to determine the role of Munc13 family proteins in MUC5AC sec...
Source: Molecular Medicine Reports - May 18, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Dysregulation of CD69 by overexpression of microRNA ‑367‑3p associated with post‑myocardial infarction cardiac fibrosis.
In conclusion, these results provide evidence that a decrease in miR‑367‑3p levels may be associated with cardiac fibrosis.
PMID: 30015935 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - July 18, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Activation of the Notch ‑Nox4‑reactive oxygen species signaling pathway induces cell death in high glucose‑treated human retinal endothelial cells.
Activation of the Notch‑Nox4‑reactive oxygen species signaling pathway induces cell death in high glucose‑treated human retinal endothelial cells.
Mol Med Rep. 2018 Nov 09;:
Authors: Jiao W, Ji J, Li F, Guo J, Zheng Y, Li S, Xu W
Abstract
Diabetic retinopathy (DR) occurs in almost all patients with diabetes and remains as one of the major causes of vision loss worldwide. Nevertheless, the molecular mechanisms underlying the pathogenesis of DR remain elusive. The present study aimed to investigate the role and association of Notch signaling and NADPH oxidase 4 (Nox4)‑mediated oxidative stress in...
Source: Molecular Medicine Reports - November 16, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
LncRNA ‑NEF is involved the regulation of gastric carcinoma cell proliferation by targeting RUNX1.
LncRNA‑NEF is involved the regulation of gastric carcinoma cell proliferation by targeting RUNX1.
Mol Med Rep. 2019 Jan 16;:
Authors: Wang X, Jiang X, Zhou L, Wang Z, Huang H, Wang M
Abstract
Neighboring enhancer of FOXA2 (NEF) is a newly discovered long non‑coding RNA (lncRNA) that serves an oncogenic function in the metastasis of hepatocellular carcinoma, while its involvement in other types of cancer and in tumor cell proliferation remain unknown. In the present study, tumor tissues and adjacent healthy tissues were obtained from patients with gastric carcinoma, and blood was extracted from pati...
Source: Molecular Medicine Reports - January 22, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Sam68 mediates high glucose ‑induced podocyte apoptosis through modulation of Bax/Bcl‑2.
This study sought to examine the effect of Sam68 on high glucose (HG)‑induced podocytes apoptosis, and the mechanism underlying this effect. Immortalized mouse podocytes were exposed to medium containing normal glucose, or HG and Sam68 siRNA, respectively. The expression of Sam68 in podocytes was determined by fluorescence quantitative PCR (qPCR), immunofluorescence and immunoblotting. The role of Sam68 in HG‑induced podocyte apoptosis was further evaluated by inhibiting Sam68 expression by Sam68 siRNA and performing flow cytometry. The mRNA and protein expression of pro‑apoptosis gene Bax and anti‑apoptotic gene B...
Source: Molecular Medicine Reports - September 7, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Long non ‑coding RNA SLNCR1 regulates non‑small cell lung cancer migration, invasion and stemness through interactions with secretory phospholipase A2.
In conclusion, lncRNA SLNCR1 may regulate cancer cell migration, invasion and stemness in NSCLC through interactions with sPLA2.
PMID: 31524254 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - September 17, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
BAFF is involved in the pathogenesis of IgA nephropathy by activating the TRAF6/NF ‑κB signaling pathway in glomerular mesangial cells.
In conclusion, BAFF enhanced the expression of fibroblast factors in the kidneys by activating the TRAF6/NF‑κB signaling pathway.
PMID: 31974601 [PubMed - in process]
Source: Molecular Medicine Reports - January 26, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
