Filtered By:
Source: Molecular Medicine Reports
This page shows you your search results in order of relevance. This is page number 3.
Order by Relevance | Date
Total 308 results found since Jan 2013.
Silencing of osterix expression by siRNA inhibits aldosterone ‑induced calcification of vascular smooth muscle cells in mice.
Silencing of osterix expression by siRNA inhibits aldosterone‑induced calcification of vascular smooth muscle cells in mice.
Mol Med Rep. 2016 Jul 8;
Authors: Gong YC, He Y, Wang H, Niu WQ, Ji KD, Li H
Abstract
The process of vascular calcification shares numerous similarities with that of skeletal mineralization and involves the deposition of hydroxyapatite crystals in arteries and cardiac valves. However, the underlying cellular mechanism remains to be fully elucidated. Microarray analysis in the present study demonstrated that greater than 2,000 genes were upregulated during the calcification of ...
Source: Molecular Medicine Reports - July 21, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Safety and toxicology of the intravenous administration of Ang2 ‑siRNA plasmid chitosan magnetic nanoparticles.
Safety and toxicology of the intravenous administration of Ang2‑siRNA plasmid chitosan magnetic nanoparticles.
Mol Med Rep. 2016 Dec 29;:
Authors: Shan X, Xu T, Liu Z, Hu X, Zhang YD, Wang B
Abstract
This aim of the present study was to investigate the safety and toxicology of intravenous administration of angiopoietin‑2 (Ang2)‑small interfering (si)RNA plasmid‑chitosan magnetic nanoparticles (CMNPs). Ang2‑CMNPs were constructed and subsequently administered at different doses to mice and rats via the tail vein. The acute (in mice) and chronic toxicity (in rats) were observed. The results of ...
Source: Molecular Medicine Reports - January 1, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Co ‑expression of murine double minute 2 siRNA and wild‑type p53 induces G1 cell cycle arrest in H1299 cells.
Co‑expression of murine double minute 2 siRNA and wild‑type p53 induces G1 cell cycle arrest in H1299 cells.
Mol Med Rep. 2017 Oct 11;:
Authors: Liu L, Zhang P, Guo H, Tang X, Liu L, Li J, Guo R, Cai Y, Liu Y, Li Y
Abstract
The therapeutic options available for the treatment of advanced non-small cell lung cancer have increased over the past decade. Small molecule gene therapy has emerged as an effective therapy for the treatment of lung cancer in vitro and in vivo although it has not been tested in a clinical setting. In particular, therapies that target the negative feedback loop between p53 an...
Source: Molecular Medicine Reports - October 20, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
CD-PLLD co-delivering docetaxel and MMP-9 siRNA plasmid for nasopharyngeal carcinoma therapy in vivo.
CD-PLLD co-delivering docetaxel and MMP-9 siRNA plasmid for nasopharyngeal carcinoma therapy in vivo.
Mol Med Rep. 2017 Jun 07;:
Authors: Liu T, Wu X, Wang Y, Hou X, Jiang G, Wu T, Xie H, Xie M
Abstract
The co-delivery of a drug and a target gene has become a primary strategy in cancer therapy. Based on our previous study, a synthesized star‑shaped co‑polymer consisting of β‑cyclodextrin (CD) and a poly(L‑lysine) dendron (PLLD) was used to co-deliver docetaxel (DOC) and matrix metalloproteinase 9 (MMP‑9) small interfering RNA, via CD‑PLLD/DOC/MMP‑9 complexes, into mice implanted with HN...
Source: Molecular Medicine Reports - October 29, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
TLR4/PKC α/occludin signaling pathway may be related to blood‑brain barrier damage.
TLR4/PKCα/occludin signaling pathway may be related to blood‑brain barrier damage.
Mol Med Rep. 2018 May 16;:
Authors: Tang Z, Guo D, Xiong L, Wu B, Xu X, Fu J, Kong L, Liu Z, Xie C
Abstract
Abnormal blood-brain barrier (BBB) is a common pathological feature in brain damage. In the present study, a brain microvascular endothelial cell (BMEC) model was established to determine the role of the toll‑like receptor 4 (TLR4)/protein kinase Cα (PKCα)/occludin signaling pathway in BBB dysfunction. Three small interfering (si)RNAs directed against PKCα were designed to investigate the molecular mechanis...
Source: Molecular Medicine Reports - June 2, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Synergistic effect of STAT3 ‑targeted small interfering RNA and AZD0530 against glioblastoma in vitro and in vivo.
Synergistic effect of STAT3‑targeted small interfering RNA and AZD0530 against glioblastoma in vitro and in vivo.
Mol Med Rep. 2019 Aug 21;:
Authors: Liu Q, Wang L, Li D, Zhao J, Chen S, Li J
Abstract
The aim of this study was to explore the synergistic effect of signal transducer and activator of transcription 3 (STAT3)‑targeted small interfering (si)RNA and AZD0530 against glioblastoma in vitro and in vivo. Glioblastoma cell lines U87 and U251 were divided into four groups and treated with control, LV‑STAT3 siRNA, AZD0530, and combined LV‑STAT3 siRNA with AZD0530, respectively. The proli...
Source: Molecular Medicine Reports - September 7, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
AQP3 small interfering RNA and PLD2 small interfering RNA inhibit the proliferation and promote the apoptosis of squamous cell carcinoma.
Authors: Wang X, Tao C, Yuan C, Ren J, Yang M, Ying H
Abstract
Aquaporin 3 (AQP3) and phospholipase D2 (PLD2) are abnormally expressed and/or localized in squamous cell carcinoma (SCC). AQP3 transports glycerol to PLD2 for the synthesis of lipid second messenger, which can mediate the effect of the AQP3/PLD2 signaling module in the regulation of keratinocyte proliferation and differentiation. However, the role of the AQP3/PLD2 signaling module in the pathogenesis of SCC remains to be fully elucidated. In the present study, the expression levels of AQP3 and PLD2 in tissue samples were examined using immunohistochemi...
Source: Molecular Medicine Reports - June 29, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Knockdown of versican V1 induces a severe inflammatory response in LPS-induced acute lung injury via the TLR2-NF-κB signaling pathway in C57BL/6J mice.
Authors: Xu L, Xue T, Zhang J, Qu J
Abstract
The versican family is important in the modulation of inflammation, however, the role of versican V1 (V1) in lipopolysaccharide (LPS)-induced acute lung injury (ALI) and the underlying mechanisms remain to be elucidated. To investigate this, the present study performed experiments in male C57BL/6J mice, which were randomly divided into a normal control group (control; n=6), an LPS‑stimulated ALI group (LPS; n=6), a scramble small interfering (si)RNA group (scramble; n=6), a V1‑siRNA group (V1‑siRNA; n=6), a scramble siRNA and LPS‑stimulated group (scramble+LPS; n...
Source: Molecular Medicine Reports - April 27, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
SDF‑1/CXCR4 axis induces apoptosis of human degenerative nucleus pulposus cells via the NF‑κB pathway.
In conclusion, the SDF‑1/CXCR4 axis promoted cell apoptosis in human degenerative NPCs via the NF‑κB pathway, thus suggesting that SDF‑1/CXCR signaling may be a therapeutic target for the treatment of degenerative IVD diseases.
PMID: 27220474 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - May 27, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
CDCA7L promotes glioma proliferation by targeting CCND1 and predicts an unfavorable prognosis.
Authors: Ji QK, Ma JW, Liu RH, Li XS, Shen FZ, Huang LY, Hui L, Ma YJ, Jin BZ
Abstract
Cell division cycle associated 7 like (CDCA7L) belongs to the JPO protein family, recently identified as a target gene of c‑Myc and is frequently dysregulated in multiple cancers. However, to the best of our knowledge, no studies to date have been carried out to investigate the functions of CDCA7L in glioma. Thus, in this study, the expression level of CDCA7L and its association with the prognosis in glioma were detected through the TCGA database. The mRNA expression levels of CDCA7L in glioblastoma (GBM) tissues and normal bra...
Source: Molecular Medicine Reports - June 9, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Phospho ‑regulation of Cdc14A by polo‑like kinase 1 is involved in β‑cell function and cell cycle regulation.
In conclusion, PLK1 promoted cell proliferation and insulin secretion while inhibiting cellular apoptosis in β‑TC3 cell lines under both low and high glucose conditions. In addition, the phospho‑regulation of Cdc14A by PLK1 may be involved in β‑TC3 cell cycle regulation and insulin secretion under high glucose conditions.
PMID: 31545409 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - September 24, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
LOX‑1 is implicated in oxidized low‑density lipoprotein‑induced oxidative stress of macrophages in atherosclerosis.
Authors: Yang HY, Bian YF, Zhang HP, Gao F, Xiao CS, Liang B, Li J, Zhang NN, Yang ZM
Abstract
Induction of oxidative stress has a causal role in atherosclerosis. The aim of the present study was to examine the role of lectin‑like oxidized low‑density lipoprotein receptor‑1 (LOX‑1) in oxidized low‑density lipoprotein (OxLDL)‑induced oxidative stress in atherosclerosis. Small interfering RNA (siRNA) technology was employed to decrease the expression of LOX‑1 in mouse RAW264.7 macrophages and the effects of LOX‑1 silencing on OxLDL‑induced reactive oxygen species (ROS) generation and NADPH oxidase (...
Source: Molecular Medicine Reports - July 16, 2015 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
STAT3‑regulated long non‑coding RNAs lnc‑7SK and lnc‑IGF2‑AS promote hepatitis C virus replication.
Authors: Xiong Y, Jia M, Yuan J, Zhang C, Zhu Y, Kuang X, Lan L, Wang X
Abstract
Long non‑coding RNAs (lncRNAs) are a class of RNAs that do not code protein but are important in diverse biological processes. In previous years, with the application of high‑throughput sequencing, a large number of lncRNAs associated with virus infections have been identified and intensively investigated, however, there are few studies examining the association between lncRNAs and HCV replication. Previous studies have demonstrated that signal transducer and activator of transcription 3 (STAT3) is activated by the hepatitis C vi...
Source: Molecular Medicine Reports - September 4, 2015 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Gene silencing of galectin-3 changes the biological behavior of Eca109 human esophageal cancer cells.
In conclusion, following successful knockdown of galecin-3 expression in Eca109 cells, the cell proliferation, migration and invasion were reduced, while the apoptosis was enhanced, which indicates that galectin silencing may represent a therapeutic strategy for EC.
PMID: 26718452 [PubMed - in process]
Source: Molecular Medicine Reports - January 16, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Downregulation of AATK mediates microRNA-558-induced resistance of A549 cells to radiotherapy.
In conclusion, these data demonstrate that the miR‑558/AATK cascade is important for the radiosensitization of lung cancer cells and may be a potential radiotherapy target.
PMID: 27485693 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - August 5, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
