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Source: Molecular Medicine Reports

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Total 308 results found since Jan 2013.

Knockdown of FAM225B inhibits the progression of the hypertrophic scar following glaucoma surgery by inhibiting autophagy.
Authors: Ma X, Liu L Abstract The formation of a hypertrophic scar (HS) may lead to failure of glaucoma surgery. Long non‑coding RNAs (lncRNAs) are involved in the formation of HSs. Moreover, family with sequence similarity 225 member B (FAM225B) is upregulated in HS. However, the role of the lncRNA FAM225B in HS remains unknown. Thus, the present study aimed to investigate the function of FAM225B in HS. Scar fibroblasts were isolated from patients who had undergone glaucoma surgery. Western blotting was used to detect the expressions of Bax, Bcl‑2, cleaved caspase 3, p62, ATG7 and Beclin 1, and reverse tra...
Source: Molecular Medicine Reports - January 27, 2021 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Lentivirus vector ‑mediated genetic manipulation of oncogenic pathways induces tumor formation in rabbit brain
Mol Med Rep. 2021 Jun;23(6):422. doi: 10.3892/mmr.2021.12061. Epub 2021 Apr 13.ABSTRACTTranslation of promising experimental therapies from rodent models to clinical success has been complicated as the novel therapies often fail in clinical trials. Existing rodent glioma models generally do not allow for preclinical evaluation of the efficiency of novel therapies in combination with surgical resection. Therefore, the aim of the present study was to develop a larger animal model utilizing lentivirus vector‑mediated oncogenic transformation in the rabbit brain. Lentiviruses carrying constitutively active AKT and H‑Ras on...
Source: Molecular Medicine Reports - April 13, 2021 Category: Molecular Biology Authors: Farizan Ahmad Anna Hyv ärinen Agnieszka Pirinen Venla Olsson Jaana Rummukainen Arto Immonen Johanna N ärväinen Pasi Tuunanen Timo Liimatainen Virve K ärkkäinen Jari Koistinaho Seppo Yl ä-Ηerttuala Source Type: research

Transforming growth factor ‑β1 functions as a competitive endogenous RNA that ameliorates intracranial hemorrhage injury by sponging microRNA‑93‑5p
Mol Med Rep. 2021 Jul;24(1):499. doi: 10.3892/mmr.2021.12138. Epub 2021 May 6.ABSTRACTIntracerebral hemorrhage (ICH) has the highest mortality rate of all stroke subtypes but an effective treatment has yet to be clinically implemented. Transforming growth factor‑β1 (TGF‑β1) has been reported to modulate microglia‑mediated neuroinflammation after ICH and promote functional recovery; however, the underlying mechanisms remain unclear. Non‑coding RNAs such as microRNAs (miRNAs) and competitive endogenous RNAs (ceRNAs) have surfaced as critical regulators in human disease. A known miR‑93 target, nuclear factor eryth...
Source: Molecular Medicine Reports - May 6, 2021 Category: Molecular Biology Authors: Han Wang Xianming Cao Xiaoqing Wen Dongling Li Yetong Ouyang Bing Bao Yuqin Zhong Zhengfang Qin Min Yin Zhiying Chen Xiaoping Yin Source Type: research

Tripterygium glycoside suppresses epithelial ‑to‑mesenchymal transition of diabetic kidney disease podocytes by targeting autophagy through the mTOR/Twist1 pathway
Mol Med Rep. 2021 Aug;24(2):592. doi: 10.3892/mmr.2021.12231. Epub 2021 Jun 24.ABSTRACTTripterygium glycoside (TG) is a traditional Chinese medicine extract with immunosuppressive, anti‑inflammatory and anti‑renal fibrosis effects. Epithelial‑mesenchymal transition (EMT) and cell apoptosis are considered to be the major cause of podocyte injury in diabetic kidney disease (DKD). However, it remains unknown as to whether TG is able to alleviate podocyte injury to prevent DKD progression. Therefore, the present study aimed to clarify the podocyte protective effects of TG on DKD. TG, Twist1 small interfering RNA (siRNA) ...
Source: Molecular Medicine Reports - June 24, 2021 Category: Molecular Biology Authors: Mei Tao Danna Zheng Xudong Liang Diandian Wu Kang Hu Juan Jin Qiang He Source Type: research