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Source: Oncology Letters

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Total 221 results found since Jan 2013.

Effects of mdig on proliferation and apoptosis of lung cancer cells.
Authors: Xu X, Cao L, Zhang Y, Lian H, Sun Z, Cui Y Abstract Expression of mineral dust-induced gene (mdig) in lung cancer NCI-H1650 cells was detected to investigate the effects of mdig on proliferation and apoptosis of NCI-H1650 cells. NCI-H1650 lung cancer cells were cultured in vitro. The expression of mdig in NCI-H1650 cells was lowered using ribonucleic acid interference (RNAi) technique. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and western blot analysis were used to detect the effects of mdig small interfering RNA (siRNA) on messenger RNA (mRNA) and the protein expression of mdi...
Source: Oncology Letters - December 15, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Acidosis promotes cell apoptosis through the G protein-coupled receptor 4/CCAAT/enhancer-binding protein homologous protein pathway.
Authors: Dong B, Zhang X, Fan Y, Cao S, Zhang X Abstract The aim of the present study was to investigate the effects of acidosis on the apoptosis of renal epithelial and endothelial cells, and the molecular pathways responsible for this. A human proximal tubular cell line, HK-2, and human umbilical vein endothelial cells (HUVECs), were transfected with control or G protein-coupled receptor 4 siRNA for 36 h. Cells were exposed to normal (pH 7.4) or acidic (pH 6.4) media. Western blot analysis was used to assess the protein expression levels of G protein-coupled receptor 4 (GPR4), CCAAT/enhancer-binding protein homol...
Source: Oncology Letters - November 9, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Knockdown of LETM1 inhibits proliferation and metastasis of human renal cell carcinoma cells.
In conclusion, these results suggest that knockdown of LETM1 exhibits tumor suppressive effects, at least in part by controlling the downstream Wnt/β-Catenin signaling pathway. Therefore, LETM1 may act as a novel therapeutic target for the treatment of RCC. PMID: 30405774 [PubMed]
Source: Oncology Letters - November 9, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Effects of PLK1 on proliferation, invasion and metastasis of gastric cancer cells through epithelial-mesenchymal transition.
In conclusion, PLK1 enhances the proliferation, migration and invasion of gastric cancer MGC-803 cells through affecting EMT. PMID: 30405751 [PubMed]
Source: Oncology Letters - November 9, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

TM4SF1 inhibits apoptosis and promotes proliferation, migration and invasion in human gastric cancer cells.
Authors: Wei Y, Shen X, Li L, Cao G, Cai X, Wang Y, Shen H Abstract Gastric cancer (GC) is associated with poor patient prognosis, and so it crucial to investigate the molecular mechanisms underlying the progression of GC. The aim of the present study was to investigate the role of transmembrane-4 L6 family member 1 (TM4SF1) in the progression of GC. TM4SF1 small interfering RNA (siRNA) and TM4SF1-expressing plasmids were employed to regulate TM4SF1 expression. In vitro experiments were performed to determine the effect of TM4SF1 on the expression of apoptosis-associated molecules and determine the role of TM4SF1 i...
Source: Oncology Letters - October 23, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Inhibition of Ep3 attenuates migration and promotes apoptosis of non-small cell lung cancer cells via suppression of TGF- β/Smad signaling.
Inhibition of Ep3 attenuates migration and promotes apoptosis of non-small cell lung cancer cells via suppression of TGF-β/Smad signaling. Oncol Lett. 2018 Nov;16(5):5645-5654 Authors: Li L, Lv Y, Yan D Abstract Non-small cell lung cancer (NSCLC) is the most common cause of cancer-associated mortality worldwide. Prostaglandin E2 (PGE2) regulates various biological processes, including invasion, proliferation and apoptosis. E-prostanoid 3 (Ep3) is a PGE2 receptor, and the functional role of Ep3 in the progression of NSCLC remains unresolved. The present study investigated the effects of Ep3 in A549 cel...
Source: Oncology Letters - October 23, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Hepatocyte growth factor-induced mesenchymal-epithelial transition factor activation leads to insulin-like growth factor 1 receptor inhibitor unresponsiveness in gastric cancer cells.
In conclusion, HGF-induced MET activation may represent a novel mechanism conferring unresponsiveness to IGF-1R-targeted agents in GC, and inhibition of MET may improve the efficacy of IGF-1R inhibitors. PMID: 30333869 [PubMed]
Source: Oncology Letters - October 21, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Leptin and its receptor in glucose metabolism of T-cell lymphoma.
In conclusion, these results suggested that leptin serves a critical role in TCL glucose uptake via the ObR. PMID: 30333864 [PubMed]
Source: Oncology Letters - October 21, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Oct3/4 is potentially useful for the suppression of the proliferation and motility of hepatocellular carcinoma cells.
Authors: Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N Abstract Hepatocellular carcinoma (HCC) cells are immature compared with healthy mature hepatocytes. Transcription factors serve a role in hepatocyte differentiation. The expression levels of transcription factors in HCC cell lines have been investigated to determine potential therapeutic targets. In the present study, the HLE, HLF, PLC/PRF/5, Huh-7, Hep3B, Huh-6 and HepG2 HCC cell lines were subjected to reverse-transcription polymerase chain reaction (RT-PCR) of transcription factors, including NANOG, Oct3/4, GATA binding protein 4 (G...
Source: Oncology Letters - September 26, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Downregulation of lncRNA PVT1 expression inhibits proliferation and migration by regulating p38 expression in prostate cancer.
Authors: Wan B, Wu HY, Lv DJ, Zhou XM, Zhong LR, Lei B, Zhang SB, Mao XM Abstract Long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) has been reported to be overexpressed in prostate cancer cells and associated with tumorigenesis in various types of cancer. However, the biological function of lncRNA PVT1 remains largely unknown. The aim of the present study was to investigate the effect of lncRNA PVT1 expression on the proliferation and migration of prostate cancer cells. Stably transfected prostate cancer cells with downregulated expression of lncRNA PVT1 were constructed by an efficient siRN...
Source: Oncology Letters - September 26, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Expression of Smo in pancreatic cancer CD44+CD24+cells and construction of a lentiviral expression vector to silence Smo.
Authors: Cong P, Yi C, Wang XY Abstract The present study focused on the roles of members of the Hedgehog (Hh) signaling pathway in the maintenance of malignant biological characteristics, such as tumorigenesis, similar to that of pancreatic tumor cells. Cluster of differentiation (CD)44+CD24+/CD44-CD24- cells were isolated from three different pancreatic cancer cell lines by flow cytometry. Among the three pancreatic cancer cell lines, the SW1990 cell line exhibited the highest percentage of CD44+CD24+ cells, which accounted for 39.9% of the total. The expression of members of the Hh signaling pathway in CD44+CD24...
Source: Oncology Letters - September 26, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Gefitinib induces non-small cell lung cancer H1650 cell apoptosis through downregulating tumor necrosis factor-related apoptosis-inducing ligand expression levels.
Authors: Yi H, Li S, Li H, Wang P, Zheng H, Cheng X Abstract Non-small cell lung cancer (NSCLC) presents severe threats to the lives of patients. Gefitinib is one of the first-line drugs available for the treatment of NSCLC in the clinical setting. The present study investigated the effects of gefitinib on NSCLC H1650 cell viability and apoptosis via MTT assays and flow cytometry. Western blot analysis was employed to detect tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression levels in H1650 cells. In the present study, H1650 cells were treated with TRAIL siRNA or an empty plasmid vector cont...
Source: Oncology Letters - September 16, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Long non-coding RNA-CCAT2 promotes the occurrence of non-small cell lung cancer by regulating the Wnt/ β-catenin signaling pathway.
Long non-coding RNA-CCAT2 promotes the occurrence of non-small cell lung cancer by regulating the Wnt/β-catenin signaling pathway. Oncol Lett. 2018 Oct;16(4):4600-4606 Authors: Zhao C, Qiao C, Zong L, Chen Y Abstract The present study aimed to investigate the biological function of colon cancer-associated transcript 2 (CCAT2) in the occurrence and progression of non-small cell lung carcinoma (NSCLC) and its potential use in the early diagnosis and molecular-targeted therapy of NSCLC. The tumor tissues, para-carcinoma tissues and associated clinical data of 36 patients with NSCLC were collected in orde...
Source: Oncology Letters - September 16, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Downregulation of peroxiredoxin II suppresses the proliferation and metastasis of gastric cancer cells.
Authors: Niu L, Liu A, Xu W, Yang L, Zhu W, Gu Y Abstract Peroxiredoxin (Prx) II is an imperative member of the superfamily of peroxidases. It serves an essential role in scavenging organic hydroperoxide and H2O2. It is involved in the development of various malignant tumors. In order to investigate the significance of Prx II expressions level in gastric cancer (GC), downregulation of Prx II was performed to investigate its role in the proliferation and migration of gastric adenocarcinoma cells. In GC cells and 45 GC specimens, the mRNA and protein expression levels of Prx II were determined using reverse transcrip...
Source: Oncology Letters - September 16, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

High serum Ephrin-B2 levels predict poor prognosis for patients with gastric cancer.
Authors: Yue WJ, Liu YP, Li M, Liu CX, Mou SJ, Li QK, Chen ZP Abstract Gastric cancer is an intractable disease with a poor prognosis and limited treatment options. Its treatment remains a major clinical challenge worldwide. Ephrin-B2 is upregulated and involved in tumor growth in various types of cancer. However, the association between ephrin-B2 and prognosis of gastric cancer, and the potential of ephrin-B2 as a therapeutic target remains unknown. The present study investigated ephrin-B2 as a prognostic factor and a therapeutic target for gastric cancer. Reverse transcription-quantitative polymerase chain reacti...
Source: Oncology Letters - September 16, 2018 Category: Cancer & Oncology Tags: Oncol Lett Source Type: research