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Source: Oncology Letters
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Total 221 results found since Jan 2013.
TPX2 regulated by miR-29c-3p induces cell proliferation in osteosarcoma via the AKT signaling pathway
Oncol Lett. 2022 May;23(5):143. doi: 10.3892/ol.2022.13262. Epub 2022 Mar 11.ABSTRACTThe present study aimed to investigate the significance of targeting protein for Xenopus kinesin-like protein 2 (TPX2) expression in osteosarcoma. First, the TPX2 expression and survival analysis data were evaluated from The Cancer Genome Atlas (TCGA) database. Next, reverse transcription-quantitative PCR was used to explore the expression of TPX2 in osteosarcoma tissues. The observed potential target relationship between TPX2 and microRNA (miR)-29c-3p was verified using TargetScan and luciferase reporter assays. Kaplan-Meier survival anal...
Source: Oncology Letters - March 28, 2022 Category: Cancer & Oncology Authors: Dongsheng Zhu Xiangfei Xu Ming Zhang Tong Wang Source Type: research
Identification of potential circular RNA biomarkers in lung adenocarcinoma: A bioinformatics analysis and retrospective clinical study
Oncol Lett. 2022 May;23(5):144. doi: 10.3892/ol.2022.13264. Epub 2022 Mar 11.ABSTRACTNon-small cell lung cancer (NSCLC) is one of the leading causes of cancer-associated mortality. Lung adenocarcinoma (LAC) is the most prevalent pathological subtype of NSCLC and accounts for ~40% of all lung cancer mortalities. There remains an urgent demand for the identification of novel biomarkers for the diagnosis and development of therapeutic strategies for LAC. In the present study, the profiles of the differentially-expressed circular RNAs (circRNAs) in LAC tissues compared with those in their corresponding non-cancerous tissues we...
Source: Oncology Letters - March 28, 2022 Category: Cancer & Oncology Authors: Yonggang Zhu Feng Cao Fei Liu Sihua Liu Lingjiao Meng Lina Gu Hanjun Zhao Meixiang Sang Baoen Shan Source Type: research
Small interfering RNA targeting N-cadherin regulates cell proliferation and migration in enzalutamide-resistant prostate cancer
Oncol Lett. 2022 Mar;23(3):90. doi: 10.3892/ol.2022.13210. Epub 2022 Jan 21.ABSTRACTEnzalutamide is one of the options for treating patients with castration-resistant or metastatic prostate cancer. However, a substantial proportion of patients become resistant to enzalutamide after a period of treatment. Cells in these tumors typically exhibit increased proliferative and migratory capabilities, in which N-cadherin (CDH2) appear to serve an important role. In the present study, by up- and downregulating the expression of CDH2, the possible effects of CDH2 on the prostate cancer cell line LNCaP were investigated. Male sex ho...
Source: Oncology Letters - February 7, 2022 Category: Cancer & Oncology Authors: Cheng-Hsin Lu Chun-Hsien Wu Pei-Fang Hsieh Chen-Yu Wu Wade Wei-Ting Kuo Chien-Hui Ou Victor Chia Hsiang Lin Source Type: research
Regulatory effect between HMGA2 and the Wnt/ β-catenin signaling pathway in the carcinogenesis of sporadic colorectal tubular adenoma
Oncol Lett. 2021 Dec;22(6):849. doi: 10.3892/ol.2021.13110. Epub 2021 Oct 25.ABSTRACTDue to the high incidence of colorectal cancer worldwide, the underlying molecular mechanisms have been extensively investigated. The Wnt/β-catenin signaling pathway plays a key role in the carcinogenesis of colorectal adenoma. In addition, the high mobility group AT-hook 2 (HMGA2) protein, which is involved in several biological processes, such as proliferation, differentiation, transformation and metastasis, is expressed at significantly high levels in colorectal cancer tissues compared with adjacent normal tissues. Currently, the role ...
Source: Oncology Letters - November 4, 2021 Category: Cancer & Oncology Authors: Dan Li Yanan Cao Juan Wang Haiyan Yang Weina Liu Jinfeng Cui Wenxin Wu Source Type: research
