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MicroRNA ‑137 exerts protective effects on hypoxia‑induced cell injury by inhibiting autophagy/mitophagy and maintaining mitochondrial function in breast cancer stem‑like cells.
MicroRNA‑137 exerts protective effects on hypoxia‑induced cell injury by inhibiting autophagy/mitophagy and maintaining mitochondrial function in breast cancer stem‑like cells. Oncol Rep. 2020 Aug 03;: Authors: Hu Q, Yuan Y, Wu Y, Huang Y, Zhao Z, Xiao C Abstract Breast cancer stem‑like cells (BCSCs) have been identified and proven to play critical roles in tumorigenesis and progression. Hypoxia is a common pathologic feature of breast cancer and potentially, at least in part, regulates the initiation, progression, and recurrence of breast cancer. However, less is known about how hypoxia regula...
Source: Oncology Reports - September 20, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Long non coding RNA OIP5 ‑AS1 promotes metastasis of breast cancer via miR‑340‑5p/ZEB2 axis.
Long non coding RNA OIP5‑AS1 promotes metastasis of breast cancer via miR‑340‑5p/ZEB2 axis. Oncol Rep. 2020 Aug 10;: Authors: Meng L, Yue X, Zhou D, Li H Abstract Breast cancer is the most common invasive cancer in women with the highest number of related deaths which is caused by distal metastasis. Recently, integrated analysis of gene expression profile suggested widespread gene dysregulation in various types of cancer. Research in the past decade has focused on long non‑coding RNAs (lncRNAs), particularly in cell proliferation, tumor progression and metastasis. OPA‑interacting protein 5 a...
Source: Oncology Reports - September 20, 2020 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Sulfasalazine ‑induced ferroptosis in breast cancer cells is reduced by the inhibitory effect of estrogen receptor on the transferrin receptor.
In conclusion SAS could trigger ferroptosis in breast cancer cells, especially in cells with low ER expression. Therefore, SAS is a potential agent for breast cancer treatment. PMID: 31173262 [PubMed - as supplied by publisher]
Source: Oncology Reports - June 8, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Cellular and radiobiological effects of carbonic anhydrase IX in human breast cancer cells.
In conclusion, combination of CAIX inhibition and irradiation is a promising treatment strategy against breast cancer with hypoxia‑induced CAIX expression. PMID: 30720123 [PubMed - as supplied by publisher]
Source: Oncology Reports - February 7, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Inhibitor of apoptosis protein ‑like protein‑2: A novel growth accelerator for breast cancer cells.
Inhibitor of apoptosis protein‑like protein‑2: A novel growth accelerator for breast cancer cells. Oncol Rep. 2018 Aug 03;: Authors: Zhu L, Zhou W, Zhu X, Xiang S, Wang S, Peng Y, Lu B, Tang P, Chen Q, Wu M, Peng X, Chen Z, Sun Z, Yang K, Xiang M, Yu D Abstract Although the inhibitor of apoptosis protein‑like protein‑2 (ILP‑2) has been shown as a serological biomarker for breast cancer, its effect on breast cancer cell growth remains elusive. The present study aimed to determine the role of ILP‑2 in breast cancer cell growth. We used immunohistochemistry to analyze ILP‑2 expression in 59 ...
Source: Oncology Reports - August 16, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

PSMB4 overexpression enhances the cell growth and viability of breast cancer cells leading to a poor prognosis.
Authors: Wang H, He Z, Xia L, Zhang W, Xu L, Yue X, Ru X, Xu Y Abstract PSMB4, proteasome subunit β4, is a member of the ubiquitin-proteasome family, and is elevated in a variety of malignancies. However, the expression level and related mechanism of PSMB4 in breast cancer remains unclear. Therefore, the present study investigated the expression level of PSMB4 in eight pairs of breast cancer and adjacent normal tissues. In addition, the relationship between the expression of PSMB4 and the clinical data of 92 breast cancer patients was discussed. First, it was found that PSMB4 expression was obviously upregulated...
Source: Oncology Reports - August 4, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Short hairpin RNA-mediated gene silencing of ADAM17 inhibits the growth of breast cancer MCF ‑7 cells in vitro and in vivo and its mechanism of action.
Short hairpin RNA-mediated gene silencing of ADAM17 inhibits the growth of breast cancer MCF‑7 cells in vitro and in vivo and its mechanism of action. Oncol Rep. 2018 Jan 26;: Authors: Hu B, Meng X, Zhang Y, Hossain MM, Wu L, Zhang Y, Peng X, Zhang X Abstract A disintegrin and metalloprotease 17 (ADAM17) is highly expressed in many malignant tumors and is closely related to their development. We showed in a previous study that silencing of ADAM17 by siRNA inhibited the growth of MCF‑7 breast cancer cells in vitro and in vivo. In the present study, we investigated the effects of ADAM17-short ha...
Source: Oncology Reports - February 4, 2018 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Suppression of Kpn β1 expression inhibits human breast cancer cell proliferation by abrogating nuclear transport of Her2.
In this study, we identified karyopherin β-1 (Kpnβ1) as a possible novel therapeutic target for BC. Western blotting was used to evaluate the expression of Kpnβ1 in four pairs of tumorous and adjacent non-tumorous tissues. The results revealed that the protein level of Kpnβ1 was higher in the cancer samples compared with those in the corresponding normal samples. Immunohistochemistry was performed on 140 BC cases and indicated that Kpnβ1 was significantly associated with clinical pathological variables. Kaplan-Meier curve revealed that high expression of Kpnβ1 was related to poor BC patient prognosis. A starvation a...
Source: Oncology Reports - December 19, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Cullin  7 is a predictor of poor prognosis in breast cancer patients and is involved in the proliferation and invasion of breast cancer cells by regulating the cell cycle and microtubule stability.
In conclusion, cullin 7 is overexpressed in breast cancer tissues which is associated with the development and prognosis of breast cancer. Cullin 7 is involved in the proliferation and invasion of breast cancer cells by regulating the cell cycle and microtubule stability. PMID: 29207184 [PubMed - as supplied by publisher]
Source: Oncology Reports - December 6, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Daam1 activates RhoA to regulate Wnt5a ‑induced glioblastoma cell invasion.
Daam1 activates RhoA to regulate Wnt5a‑induced glioblastoma cell invasion. Oncol Rep. 2017 Dec 01;: Authors: Liu G, Yan T, Li X, Sun J, Zhang B, Wang H, Zhu Y Abstract The signaling pathway of dishevelled-associated activator of morphogenesis 1 (Daam1) triggered by Wnt5a drives cell movement and migration during breast cancer metastasis. However, Wnt5a signaling in glioblastoma progression remains poorly defined. Wnt5a expression and activations of RhoA, Cdc42, and Rac1 were detected in human glioblastoma tissues by using ELISA assays and small G-protein activation assays, respectively. The cell inv...
Source: Oncology Reports - December 6, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

MicroRNA-133a acts as a tumour suppressor in breast cancer through targeting LASP1.
Authors: Sui Y, Zhang X, Yang H, Wei W, Wang M Abstract Many microRNAs (miRs) have been demonstrated to play promoting or tumor suppressive roles in human cancers including breast cancer. However, the molecular mechanism of miR-133a underlying the malignant progression of breast cancer still remains obscure. In the present study we observed that the expression of miR-133a was significantly downregulated in breast cancer tissues and cell lines, when compared with adjacent non-tumor tissues and normal breast cell line, respectively. Reduced miR-133a levels were significantly associated with advanced clinical stage, l...
Source: Oncology Reports - December 6, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Placenta-specific protein 1 promotes cell proliferation and invasion in non-small cell lung cancer.
Authors: Yang L, Zha TQ, He X, Chen L, Zhu Q, Wu WB, Nie FQ, Wang Q, Zang CS, Zhang ML, He J, Li W, Jiang W, Lu KH Abstract Pulmonary carcinoma-associated proteins have emerged as crucial players in governing fundamental biological processes such as cell proliferation, apoptosis and metastasis in human cancers. Placenta-specific protein 1 (PLAC1) is a cancer-related protein, which is activated and upregulated in a variety of malignant tissues, including prostate cancer, gastric adenocarcinoma, colorectal, epithelial ovarian and breast cancer. However, its biological role and clinical significance in non-small cell...
Source: Oncology Reports - November 16, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

P2Y2 receptor promotes the migration and invasion of breast cancer cells via EMT-related genes Snail and E-cadherin.
Authors: Qiu Y, Liu Y, Li WH, Zhang HQ, Tian XX, Fang WG Abstract Adenosine 5'-triphosphate (ATP) is one of the most abundant biochemical constituents within the tumor microenvironment and is postulated to play critical roles in the progression of a number of types of tumors via interaction with the P2Y2 receptor. In the present study, we demonstrated that the P2Y2 receptor was highly expressed in MCF7 and Hs578T breast cancer cells. Downregulation of the P2Y2 receptor by small interfering RNA (siRNA) significantly attenuated ATP- or UTP-driven migration and invasion of the breast cancer cells as well as expressio...
Source: Oncology Reports - November 9, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Leptin induces ROS via NOX5 in healthy and neoplastic mammary epithelial cells.
Authors: Mahbouli S, Der Vartanian A, Ortega S, Rougé S, Vasson MP, Rossary A Abstract NADPH oxidase (NOX) complexes (a family of seven isoforms) drive cellular ROS production in patho-logical processes such as cancer. NOX-driven ROS production is involved in cell mechanisms from signalling to oxidative stress. Leptin, an adipokine overexpressed in obese patients, has been investigated in studies on breast carcinogenesis, but its effects on oxidative stress remain largely unexplored, especially in breast cancer. The study used three human mammary epithelial cell models presenting different neoplastic status (healt...
Source: Oncology Reports - October 20, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

GRO α overexpression drives cell migration and invasion in triple negative breast cancer cells.
In conclusion, our study provides strong evidence to suggest that GROα is a critical modulator of TNBC migration/invasion and proposes GROα as a potential therapeutic target for treatment of TNBC metastasis. PMID: 28560447 [PubMed - as supplied by publisher]
Source: Oncology Reports - June 2, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

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