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Source: American Journal of Translational Research
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Blockade of interleukin-6 receptor attenuates apoptosis and modulates the inflammatory response in Mycoplasma pneumoniae infected A549 cells
CONCLUSION: Silencing the IL-6 gene can reduce the MP-induced inflammatory response and oxidative stress of A549 cells, enhance cell viability and inhibit apoptosis. Meanwhile, it was also found that STAT3 expression was inhibited after silencing IL-6 gene expression. Therefore, it is speculated that IL-6 may play a role by regulating STAT3, but its exact molecular biological mechanism still needs to be further explored.PMID:36247299 | PMC:PMC9556488
Source: American Journal of Translational Research - October 17, 2022 Category: Research Authors: Wei Fang Jingyu Huang Jun Wang Tengyi Huang Dajia Lin Jun Yin Source Type: research
