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Source: American Journal of Translational Research
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Total 412 results found since Jan 2013.
LncRNA MNX1-AS1 contributes to lung adenocarcinoma progression by targeting the miR-34a/SIRT1 axis
Am J Transl Res. 2022 Jul 15;14(7):4977-4989. eCollection 2022.ABSTRACTLncRNA MNX1-AS1 is known to be involved in progression of several tumor types. However, few studies have investigated the molecular mechanism of MNX1-AS1 in lung adenocarcinoma (LAC). To explore the function of MNX1-AS1 in the pathogenesis of LAC, qRT-PCR was performed to show MNX1-AS1 expression. MNX1-AS1 expression in LAC cells was suppressed by siRNA to detect the biologic behavior. The relationships among miR-34a, MNX1-AS1 and SIRT1 were confirmed by pull-down and dual-luciferase reporter assay. Whether MNX1-AS1 was involved in LAC by targeting miR-...
Source: American Journal of Translational Research - August 12, 2022 Category: Research Authors: Gaofeng Liu Yong Zhang Xiaozhen Zhang Yan Liu Yanbin Xu Sujuan Cui Gang Li Jianjun Wang Source Type: research
Downregulation of miR-145 alleviates ox-LDL-induced inflammation by targeting QKI in macrophages
CONCLUSION: miR-145 regulates the inflammatory response induced by macrophage activation through targeting QKI. It provides a means for AS targeted therapy.PMID:35836907 | PMC:PMC9274569
Source: American Journal of Translational Research - July 15, 2022 Category: Research Authors: Xueqiang Feng Fuwang Yao Yuqin Lang Zhibin Cao Source Type: research
LAP+CD4+T cells regulate the anti-tumor role of CIK cells in colorectal cancer through IL-10 and TGF- β
Am J Transl Res. 2022 Jun 15;14(6):3716-3728. eCollection 2022.ABSTRACTThe rate of colorectal cancer (CRC) is increasing. Adoptive immune cell therapy (ACT) is a research hotspot in CRC treatment, and the common adoptive cells are cytokine-induced killer cells (CIK). The problem of ACT is that some regulatory T cells (Treg) will affect the efficacy. Latent associated polypeptide (LAP)+CD4+T is a new Treg, and its immunosuppressive effect is much higher than that of traditional Tregs. This research mainly explored the influence of LAP+CD4+T cells on anti-tumor lethality of CIK cells, so as to fill this gap. The LAP+CD4+T CI...
Source: American Journal of Translational Research - July 15, 2022 Category: Research Authors: Wu Zhong Chuanfa Fang Hongquan Liu Lei Zhang Xiaofei Zhang Junqiao Zhong Xianping He Leichang Zhang Source Type: research
Downregulation of miR-145 alleviates ox-LDL-induced inflammation by targeting QKI in macrophages
CONCLUSION: miR-145 regulates the inflammatory response induced by macrophage activation through targeting QKI. It provides a means for AS targeted therapy.PMID:35836907 | PMC:PMC9274569
Source: American Journal of Translational Research - July 15, 2022 Category: Research Authors: Xueqiang Feng Fuwang Yao Yuqin Lang Zhibin Cao Source Type: research
