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Total 80 results found since Jan 2013.
Inhibiting HER3 Hyperphosphorylation in HER2 ‐Overexpressing Breast Cancer through Multimodal Therapy with Branched Gold Nanoshells
A multimodal theranostic nanoplatform to treat breast cancer overexpressing the human epidermal growth factor receptors 2 (HER2) and 3 (HER3) is developed, and consisting of doxorubicin-loaded branched gold nanoshells functionalized with a small interfering RNA against HER3 and the HER2-specific antibody Trastuzumab able to simultaneously combine chemo- and photothermal, RNA silencing and immuno-therapies overcoming chemoresistance and reducing tumor size in vivo. AbstractTreatment failure in breast cancers overexpressing human epidermal growth factor receptor 2 (HER2) is associated mainly to the upregulation of human epid...
Source: Small - August 26, 2023 Category: Nanotechnology Authors: Eva Villar ‐Alvarez,
Irene Golán‐Cancela,
Alberto Pardo,
Brenda Velasco,
Javier Fernández‐Vega,
Adriana Cambón,
Abeer Al‐Modlej,
Antonio Topete,
Silvia Barbosa,
José A. Costoya,
Pablo Taboada Tags: Research Article Source Type: research
M2 Macrophage Membrane ‐Mediated Biomimetic‐Nanoparticle Carrying COX‐siRNA Targeted Delivery for Prevention of Tendon Adhesions by Inhibiting Inflammation (Small 33/2023)
Targeted Delivery SystemsJun Tan, You Lang Zhou, and co-workers construct successfully an M2M@PLGA/COX-siRNA delivery system and measure its targeting properties and therapeutic effects on a rat model of flexor digitorum longus (FDL) tendon injury combined with rotator cuff injury. Treatment outcomes indicate that the M2M@PLGA delivery system could provide an effective biological strategy for preventing multiple tendon adhesions. More details can be found in article number2300326.
Source: Small - August 17, 2023 Category: Nanotechnology Authors: Jie Sun,
Fei Ju,
Jing Jin,
Hao Liang Wang,
Zhi Jie Li,
Yu Cheng Sun,
Qing Zhong Chen,
Qian Qian Yang,
Jun Tan,
You Lang Zhou Tags: Inside Back Cover Source Type: research
Massively Parallel High ‐Throughput Single‐Cell Patterning and Large Biomolecular Delivery in Mammalian Cells Using Light Pulses
High-throughput single-cell patterning is presented for massively parallel optoporation-mediated intracellular delivery of small to very large cargo such as PI dye (668 Da), Dextran (3000 MW), siRNA (20–24 bp), and enzyme (464 kDa), using a titanium micro-dish device. The approach is compact, robust, easy to use and potentially applicable for single-cell therapy and diagnostics. AbstractThe recent advancements of single-cell analysis have significantly enhanced the ability to understand cellular physiology when compared to bulk cellular analysis. Here a massively parallel single-cell patterning and very large biomole...
Source: Small - August 7, 2023 Category: Nanotechnology Authors: Gayathri R,
Srabani Kar,
Moeto Nagai,
Pallab Sinha Mahapatra,
Tuhin Subhra Santra Tags: Research Article Source Type: research
Positron Emission Tomography Studies of the Biodistribution, Translocation, and Fate of Poly Allyl Amine ‐Based Carriers for Sirna Delivery by Systemic and Intratumoral Administration.
Positron emission tomography is used to study the fate of polyplexes formed by siRNA and modified polyamines. Polyplexes are prepared with either radiolabeled siRNA or radiolabeled polyamines. By comparing biodistribution patterns of labeled siRNA and labeled polyamines conclusions are driven on the stability of the polyplexes in vivo. AbstractPolyamine-based vectors offer many advantages for gene therapy, but they are hampered by a limited knowledge on their biological fate and efficacy for nucleic acid delivery. The18F radiolabeled siRNA is complexed with poly(allyl amine) hydrochloride (PAH), PEGylated PAH (PAHPEG), or ...
Source: Small - August 4, 2023 Category: Nanotechnology Authors: Cristina Simo,
Cristian Salvador,
Patrizia Andreozzi,
Vanessa Gomez ‐Vallejo,
Gabriela Romero,
Damien Dupin,
Jordi Llop,
Sergio E. Moya Tags: Research Article Source Type: research
Carbon Dots with Guanidinium and Amino Acid Functional Groups for Targeted Small Interfering RNA Delivery toward Tumor Gene Therapy (Small 31/2023)
This study provides a versatile strategy for tumor-targeted gene therapy.
Source: Small - August 3, 2023 Category: Nanotechnology Authors: Huimin Xu,
Jianqiao Chang,
Hao Wu,
Haoyu Wang,
Wenjing Xie,
Yunchao Li,
Xiaohong Li,
Yang Zhang,
Louzhen Fan Tags: Frontispiece Source Type: research
Simultaneous Delivery of Doxorubicin and EZH2 ‐Targeting siRNA by Vortex Magnetic Nanorods Synergistically Improved Anti‐Tumor Efficacy in Triple‐Negative Breast Cancer
A novel nanomedicine is synthesized based on Fe3O4 vortex nanorods loaded with doxorubicin (DOX) and EZH2 siRNAs and coated with a macrophage membrane. It shows a preferential tumor enrichment profile, thus leading to highly efficient drug delivery at the tumor site. Combining chemotherapy and gene therapy exhibits synergistic antitumor activity in a preclinical TNBC model. AbstractTriple-negative breast cancer (TNBC), one of the most aggressive types of breast cancer, currently lacks a targeted therapy and has a high clinical recurrence rate. The present study reports an engineered magnetic nanodrug based on Fe3O4 vortex ...
Source: Small - June 28, 2023 Category: Nanotechnology Authors: Yunshu Lu,
Fenfen Gu,
Yuwei Ma,
Ruonan Li,
Yi Luo,
Xianhong Da,
Lan Jiang,
Xiang Li,
Yan Liu Tags: Research Article Source Type: research
Ionizable Lipid with Supramolecular Chemistry Features for RNA Delivery In Vivo
In this report, supramolecular chemistry concepts are incorporated into the rational design of a new ionizable lipid, C3-K2-E14, for systemic administration. This lipid incorporates a cone-shaped structure intended to facilitate cell bilayer disruption, and three tertiary amines to improve RNA binding. Additionally, hydroxyl and amide motifs are incorporated to further enhance RNA binding and improve LNP stability. Optimization of messenger RNA (mRNA) and small interfering RNA (siRNA) formulation conditions and lipid ratios produce LNPs with favorable diameter (<150 nm), polydispersity index (<0.15), and RNA encaps...
Source: Small - June 14, 2023 Category: Nanotechnology Authors: Alanna M. Manning,
Grayson Tilstra,
Aniqa B. Khan,
Julien Couture ‐Senécal,
Yan Ming Anson Lau,
Janice Pang,
Amina A. Abow,
Clinton S. Robbins,
Omar F. Khan Tags: Research Article Source Type: research
Precision Therapy of Recurrent Breast Cancer through Targeting Different Malignant Tumor Cells with a HER2/CD44‐Targeted Hydrogel Nanobot
Schematic illustration of the preparation of a HER2/CD44-targeted hydrogel nanobot (ALPR) by embedding the positively charged bio-responsive, liposome-encapsulated nanoparticles (LPR) formed by cationic liposome DOTAP/DOPE, survivin siRNA, andD-(KLAKLAK)2GGR16 (KLA-R16) into negatively charged Herceptin/hyaluronic acid cross-linked nanohydrogels (Herceptin-HA). AbstractHeterogeneity and drug resistance of tumor cells are the leading causes of incurability and poor survival for patients with recurrent breast cancer. In order to accurately deliver the biological anticancer drugs to different subtypes of malignant tumor cells...
Source: Small - May 8, 2023 Category: Nanotechnology Authors: Juan Chen,
Jinjin Li,
Xiaolu Sun,
Huixia Lu,
Kuai Liu,
Zhenbo Li,
Jianyue Guan,
Huiling Song,
Wei Wei,
Yanhong Ge,
Qiong Fan,
Wei Bao,
Buyong Ma,
Zixiu Du Tags: Research Article Source Type: research
Emergency Treatment and Photoacoustic Assessment of Spinal Cord Injury Using Reversible Dual ‐Signal Transform‐Based Selenium Antioxidant
Schematic representation of the selenium-based antioxidant defense nanosystem Se@BDP-DOH NPs for photoacoustic monitoring of spinal cord injury. AbstractSpinal cord injury (SCI), following explosive oxidative stress, causes an abrupt and irreversible pathological deterioration of the central nervous system. Thus, preventing secondary injuries caused by reactive oxygen species (ROS), as well as monitoring and assessing the recovery from SCI are critical for the emergency treatment of SCI. Herein, an emergency treatment strategy is developed for SCI based on the selenium (Se) matrix antioxidant system to effectively inhibit ...
Source: Small - May 2, 2023 Category: Nanotechnology Authors: Zhisheng Ji,
Judun Zheng,
Yanming Ma,
Hongyi Lei,
Weiqiang Lin,
Jialin Huang,
Hua Yang,
Guowei Zhang,
Bin Li,
Bowen Shu,
Xianjin Du,
Jian Zhang,
Hongsheng Lin,
Yuhui Liao Tags: Research Article Source Type: research
M2 Macrophage Membrane ‐Mediated Biomimetic‐Nanoparticle Carrying COX‐siRNA Targeted Delivery for Prevention of Tendon Adhesions by Inhibiting Inflammation
An M2M@PLGA/COX-siRNA delivery system is successfully constructed and measured its targeting properties and therapeutic effects on a rat model of flexor digitorum longus tendon injury combined with rotator cuff injury. These findings indicate that the M2M@PLGA delivery system can provide an effective biological strategy for preventing m ultiple tendon adhesions. AbstractTendon adhesion is the most common outcome of tendon or tendon-to-bone healing after injury. Our group developed a hydrogel-nanoparticle sustained-release system previously to inhibit cyclooxygenases (COXs) expression and consequently prevent tendon a...
Source: Small - April 5, 2023 Category: Nanotechnology Authors: Jie Sun,
Fei Ju,
Jing Jin,
Hao Liang Wang,
Zhi Jie Li,
Yu Cheng Sun,
Qing Zhong Chen,
Qian Qian Yang,
Jun Tan,
You Lang Zhou Tags: Research Article Source Type: research
Carbon Dots with Guanidinium and Amino Acid Functional Groups for Targeted Small Interfering RNA Delivery toward Tumor Gene Therapy
Large amino acid mimicking carbon dots with guanidinium functionalization (LAAM GUA-CDs) can be prepared to carry small interfering RNA by multiple hydrogen bonds and target to tumor tissues specifically through LAT1 receptor. After loading siBcl-2 as a therapeutic agent, LAAM GUA-CDs/siBcl-2 bring about superior antitumor effects without side effects during the gene therapy. AbstractSmall interfering RNA (siRNA)-based gene therapy represents a promising strategy for tumor treatment. Novel gene vectors that can achieve targeted delivery of siRNA to the tumor cells without causing any side effects are urgently needed. To th...
Source: Small - February 25, 2023 Category: Nanotechnology Authors: Huimin Xu,
Jianqiao Chang,
Hao Wu,
Haoyu Wang,
Wenjing Xie,
Yunchao Li,
Xiaohong Li,
Yang Zhang,
Louzhen Fan Tags: Research Article Source Type: research
Peptidyl Virus ‐Like Nanovesicles as Reconfigurable “Trojan Horse” for Targeted siRNA Delivery and Synergistic Inhibition of Cancer Cells
Peptidyl virus-like nanovesicles (pVLNs) composed of bilayer membranes are assembled by the peptides and siRNA. The targeting and enzyme-responsive sequences on the bilayer's surface allow the pVLNs to enter cancer cells with high efficiency and control the release of genetic drugs in response to the subcellular environment. The resulting gene silencing efficiency is 92% and cancer cell mortality is 96%. AbstractThe self-assembly of peptidyl virus-like nanovesicles (pVLNs) composed of highly ordered peptide bilayer membranes that encapsulate the small interfering RNA (siRNA) is reported. The targeting and enzyme-responsive...
Source: Small - November 14, 2022 Category: Nanotechnology Authors: Zixuan Wang,
Dongzhao Hao,
Yuefei Wang,
Jinwu Zhao,
Jiaxing Zhang,
Xi Rong,
Jiaojiao Zhang,
Jiwei Min,
Wei Qi,
Rongxin Su,
Mingxia He Tags: Research Article Source Type: research
TfR Aptamer Enhanced Blood ‐Brain Barrier Penetration of Biomimetic Nanocomplexes for Intracellular Transglutaminase 2 Imaging and Silencing in Glioma
Biomimetic nanocomplex (TMPsM) nanopartcles with dual blood-brain barrier (BBB) targeting capability are prepared for simultaneous accurate diagnosis and effective treatment of glioma through single intracellular transglutaminase 2-triggered self-assembly aggregation-induced emission imaging and RNAi therapy. The dual BBB targeting biomimetic outer shells endow it with enhanc ed BBB penetration, prolonged blood circulation, and ensure the delivery of inner cores into brain tumor sites for theranostic agents release. AbstractEngineering a versatile nanocomplex integrating effective penetration of the blood-brain barrier (...
Source: Small - October 6, 2022 Category: Nanotechnology Authors: Juan Su,
Zhipeng Yao,
Zixuan Chen,
Sisi Zhou,
Zhi Wang,
Hongping Xia,
Songqin Liu,
Yafeng Wu Tags: Research Article Source Type: research
Unprotonatable and ROS ‐Sensitive Nanocarrier for NIR Spatially Activated siRNA Therapy with Synergistic Drug Effect
An unprotonatable and reactive oxygen species-responsive nanocarrier is designed to co-deliver photodynamic reagent chlorin e6 (Ce6) and small interfering RNA (siRNA). Owing to the unprotonatable property and near infrared-activated photochemical internalization effect, the cationic nanocarrier spatially controls siRNA activity “on/off”, turning on siRNA therapy with the synergistic effect of Ce6-based photodynamic therapy in tumor tissue and turning off siRNA activity in normal tissues. AbstractAlthough small interfering RNA (siRNA) therapy has achieved great progress, unwanted gene inhibition in normal tissues severe...
Source: Small - September 12, 2022 Category: Nanotechnology Authors: Shaohui Deng,
Shiyin Wang,
Zecong Xiao,
Du Cheng Tags: Research Article Source Type: research
Intranasal Delivery of BACE1 siRNA and Rapamycin by Dual Targets Modified Nanoparticles for Alzheimer's Disease Therapy
Aleuria aurantia lectin (AAL) and β-amyploid (Aβ)-binding peptides (KLVFF) modified PEGylated dendrigraft poly-L-lysines (DGLs) encapsulate small interfering RNA of β-site precursor protein (APP) cleaving enzyme-1 (BACE1 siRNA) and rapamycin for Alzheimer's disease (AD) treatment by nasal administration. Dual target modific ation increases about 1.4-fold of drug accumulation in the brain. Furthermore, the combination of BACE1 siRNA, rapamycin, and KLVFF greatly improves the cognition of transgenic AD mice. AbstractAlzheimer's disease (AD), as a progressive and irreversible brain disorder, remains the most univer...
Source: Small - June 30, 2022 Category: Nanotechnology Authors: Xiaotong Yang,
Wenqin Yang,
Xue Xia,
Ting Lei,
Zhihang Yang,
Wenfeng Jia,
Yang Zhou,
Guo Cheng,
Huile Gao Tags: Research Article Source Type: research
