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Total 80 results found since Jan 2013.

Unprotonatable and ROS ‐Sensitive Nanocarrier for NIR Spatially Activated siRNA Therapy with Synergistic Drug Effect
An unprotonatable and reactive oxygen species-responsive nanocarrier is designed to co-deliver photodynamic reagent chlorin e6 (Ce6) and small interfering RNA (siRNA). Owing to the unprotonatable property and near infrared-activated photochemical internalization effect, the cationic nanocarrier spatially controls siRNA activity “on/off”, turning on siRNA therapy with the synergistic effect of Ce6-based photodynamic therapy in tumor tissue and turning off siRNA activity in normal tissues. AbstractAlthough small interfering RNA (siRNA) therapy has achieved great progress, unwanted gene inhibition in normal tissues severe...
Source: Small - September 12, 2022 Category: Nanotechnology Authors: Shaohui Deng, Shiyin Wang, Zecong Xiao, Du Cheng Tags: Research Article Source Type: research

Pulmonary Codelivery of Doxorubicin and siRNA by pH‐Sensitive Nanoparticles for Therapy of Metastatic Lung Cancer
In this study, DOX is conjugated onto polyethylenimine (PEI) by using cis‐aconitic anhydride (CA, a pH‐sensitive linker) to obtain PEI‐CA‐DOX conjugates. The PEI‐CA‐DOX/siRNA complex nanoparticles are formed spontaneously via electrostatic interaction between cationic PEI‐CA‐DOX and anionic siRNA. The drug release experiment shows that DOX releases faster at acidic pH than at pH 7.4. Moreover, PEI‐CA‐DOX/Bcl2 siRNA complex nanoparticles show higher cytotoxicity and apoptosis induction in B16F10 cells than those treated with either DOX or Bcl2 siRNA alone. When the codelivery systems are directly sprayed...
Source: Small - July 1, 2015 Category: Nanotechnology Authors: Caina Xu, Ping Wang, Jingpeng Zhang, Huayu Tian, Kinam Park, Xuesi Chen Tags: Full Paper Source Type: research

Peptide‐like Polymers Exerting Effective Glioma‐Targeted siRNA Delivery and Release for Therapeutic Application
Lipopolymer 49, a solid‐phase synthesized T‐shaped peptide‐like oligoamide containing two central oleic acids, 20 aminoethane, and two terminal cysteine units, is identified as very potent and biocompatible small interfering RNA (siRNA) carrier for gene silencing in glioma cells. This carrier is combined with a novel targeting polymer 727, containing a precise sequence of Angiopep 2 targeting peptide, linked with 28 monomer units of ethylene glycol, 40 aminoethane, and two terminal cysteines in siRNA complex formation. Angiopep‐polyethylene glycol (PEG)/siRNA polyplexes exhibit good nanoparticle features, effective...
Source: Small - July 1, 2015 Category: Nanotechnology Authors: Sai An, Dongsheng He, Ernst Wagner, Chen Jiang Tags: Full Paper Source Type: research

Worm ‐Like Biomimetic Nanoerythrocyte Carrying siRNA for Melanoma Gene Therapy
This study reports a third type of nanoworm, biomimetic nanoerythrocytes for siRNA delivery, except for filomicelle and nanoworm iron ‐oxide particle, which is the first approach that allows for targeted siRNA delivery by a process involving red blood cell (RBC) membrane cloaking of charge‐reversible polyplexes of siRNA and polycation. RBC membrane cloaking protects siRNA from RNase A degradation. Moreover, the RBC membrane‐ cloaked charge‐reversible siRNA vector (RBC‐reversible polyplex (RP)) not only stays longer in the blood circulation than that of negatively charged bovine serum albumin (BSA) spheres and pos...
Source: Small - October 17, 2018 Category: Nanotechnology Authors: Yanming Wang, Xin Ji, Miaoliang Ruan, Wen Liu, Rongguang Song, Jian Dai, Wei Xue Tags: Full Paper Source Type: research

Positron Emission Tomography Studies of the Biodistribution, Translocation, and Fate of Poly Allyl Amine ‐Based Carriers for Sirna Delivery by Systemic and Intratumoral Administration.
Positron emission tomography is used to study the fate of polyplexes formed by siRNA and modified polyamines. Polyplexes are prepared with either radiolabeled siRNA or radiolabeled polyamines. By comparing biodistribution patterns of labeled siRNA and labeled polyamines conclusions are driven on the stability of the polyplexes in vivo. AbstractPolyamine-based vectors offer many advantages for gene therapy, but they are hampered by a limited knowledge on their biological fate and efficacy for nucleic acid delivery. The18F radiolabeled siRNA is complexed with poly(allyl amine) hydrochloride (PAH), PEGylated PAH (PAHPEG), or ...
Source: Small - August 4, 2023 Category: Nanotechnology Authors: Cristina Simo, Cristian Salvador, Patrizia Andreozzi, Vanessa Gomez ‐Vallejo, Gabriela Romero, Damien Dupin, Jordi Llop, Sergio E. Moya Tags: Research Article Source Type: research

Iron‐Oxide‐Based Nanovector for Tumor Targeted siRNA Delivery in an Orthotopic Hepatocellular Carcinoma Xenograft Mouse Model
Hepatocellular carcinoma (HCC) is one of the deadliest cancers worldwide. Small interfering RNA (siRNA) holds promise as a new class of therapeutics for HCC, as it can achieve sequence‐specific gene knockdown with low cytotoxicity. However, the main challenge in the clinical application of siRNA lies in the lack of effective delivery approaches that need to be highly specific and thus incur low or no systemic toxicity. Here, a nonviral nanoparticle‐based gene carrier is presented that can specifically deliver siRNA to HCC. The nanovector (NP‐siRNA‐GPC3 Ab) is made of an iron oxide core coated with chitosan‐polyet...
Source: Small - December 1, 2015 Category: Nanotechnology Authors: Kui Wang, Forrest M. Kievit, Jonathan G. Sham, Mike Jeon, Zachary R. Stephen, Arvind Bakthavatsalam, James O. Park, Miqin Zhang Tags: Full Paper Source Type: research

Cooperative Treatment of Metastatic Breast Cancer Using Host–Guest Nanoplatform Coloaded with Docetaxel and siRNA
Conventional chemotherapy shows moderate efficiency against metastatic cancer since it targets only part of the mechanisms regulating tumor growth and metastasis. Here, gold nanorod (GNR)‐based host‐guest nanoplatforms loaded with docetaxel (DTX) and small interfering RNA (siRNA)‐p65 (referred to as DTX‐loaded GNR (GDTX)/p65) for chemo‐, RNA interference (RNAi), and photothermal ablation (PTA) cooperative treatment of metastatic breast cancer are reported. To prepare the nanoplatform, GNRs are first coated with cyclodextrin (CD)‐grafted polyethylenimine (PEI) and then loaded with DTX and siRNA through host–gu...
Source: Small - December 10, 2015 Category: Nanotechnology Authors: Dangge Wang, Tingting Wang, Zhiai Xu, Haijun Yu, Bing Feng, Junying Zhang, Chengyue Guo, Qi Yin, Zhiwen Zhang, Yaping Li Tags: Full Paper Source Type: research

Magnetic Core–Shell Silica Nanoparticles with Large Radial Mesopores for siRNA Delivery
A novel type of magnetic core–shell silica nanoparticles is developed for small interfering RNA (siRNA) delivery. These nanoparticles are fabricated by coating super‐paramagnetic magnetite nanocrystal clusters with radial large‐pore mesoporous silica. The amine functionalized nanoparticles have small particle sizes around 150 nm, large radial mesopores of 12 nm, large surface area of 411 m2 g−1, high pore volume of 1.13 cm3 g−1 and magnetization of 25 emu g−1. Thus, these nanoparticles possess both high loading capacity of siRNA (2 wt%) and strong magnetic response under an external magnetic field. An acid‐li...
Source: Small - May 18, 2016 Category: Nanotechnology Authors: Lin Xiong, Jingxu Bi, Youhong Tang, Shi‐Zhang Qiao Tags: Full Paper Source Type: research

Magnetic Core –Shell Silica Nanoparticles with Large Radial Mesopores for siRNA Delivery
A novel type of magnetic core–shell silica nanoparticles is developed for small interfering RNA (siRNA) delivery. These nanoparticles are fabricated by coating super‐paramagnetic magnetite nanocrystal clusters with radial large‐pore mesoporous silica. The amine functionalized nanoparticles have small particle sizes around 150 nm, large radial mesopores of 12 nm, large surface area of 411 m2 g−1, high pore volume of 1.13 cm3 g−1 and magnetization of 25 emu g−1. Thus, these nanoparticles possess both high loading capacity of siRNA (2 wt%) and strong magnetic response under an external magnetic field. An acid‐li...
Source: Small - May 18, 2016 Category: Nanotechnology Authors: Lin Xiong, Jingxu Bi, Youhong Tang, Shi ‐Zhang Qiao Tags: Full Paper Source Type: research

Intranasal Delivery of BACE1 siRNA and Rapamycin by Dual Targets Modified Nanoparticles for Alzheimer's Disease Therapy
Aleuria aurantia lectin (AAL) and β-amyploid (Aβ)-binding peptides (KLVFF) modified PEGylated dendrigraft poly-L-lysines (DGLs) encapsulate small interfering RNA of β-site precursor protein (APP) cleaving enzyme-1 (BACE1 siRNA) and rapamycin for Alzheimer's disease (AD) treatment by nasal administration. Dual target modific ation increases about 1.4-fold of drug accumulation in the brain. Furthermore, the combination of BACE1 siRNA, rapamycin, and KLVFF greatly improves the cognition of transgenic AD mice. AbstractAlzheimer's disease (AD), as a progressive and irreversible brain disorder, remains the most univer...
Source: Small - June 30, 2022 Category: Nanotechnology Authors: Xiaotong Yang, Wenqin Yang, Xue Xia, Ting Lei, Zhihang Yang, Wenfeng Jia, Yang Zhou, Guo Cheng, Huile Gao Tags: Research Article Source Type: research

A Poly(Propyleneimine) Dendrimer ‐Based Polyplex‐System for Single‐Chain Antibody‐Mediated Targeted Delivery and Cellular Uptake of SiRNA
This study reports a new modular polyplex carrier system for targeted delivery of siRNA, which is based on transfection‐disabled maltose‐modified poly(propyleneimine)‐dendrimers (mal‐PPI) bioconjugated to single chain fragment variables (scFvs). To achieve targeted delivery into tumor cells expressing the epidermal growth factor receptor variant III (EGFRvIII), monobiotinylated anti‐EGFRvIII scFv fused to a Propionibacterium shermanii transcarboxylase‐derived biotinylation acceptor (P‐BAP) is bioconjugated to mal‐PPI through a novel coupling strategy solely based on biotin–neutravidin bridging. In contras...
Source: Small - May 22, 2017 Category: Nanotechnology Authors: Stefanie Tietze, Isabell Schau, Susanne Michen, Franka Ennen, Andreas Janke, Gabriele Schackert, Achim Aigner, Dietmar Appelhans, Achim Temme Tags: Full Paper Source Type: research

Modularized Gold Nanocarriers for TAT ‐Mediated Delivery of siRNA
Targeted delivery of siRNA controlled by near‐infrared light using hollow gold nanoshells has been demonstrated in cancer and stem cells models. Here, a universal surface module and several functionalization rules for the maximized delivery of short nucleic acids (here, siRNA) applicable for diverse gold nanocarriers are described. Streptavidin is devised as a handle to assemble biotinylated cell penetrating peptides (e.g., transactivating transcriptional activator (TAT)), as well as an insulator between the positive charge of TAT and the dense negative charge of RNA. However, direct linking of streptavidin to functional...
Source: Small - November 17, 2016 Category: Nanotechnology Authors: Xiao Huang, Yifan Lai, Gary B. Braun, Norbert O. Reich Tags: Full Paper Source Type: research

Radicals Scavenging MOFs Enabling Targeting Delivery of siRNA for Rheumatoid Arthritis Therapy
An active targeting nanomedicine based on metal-organic frameworks is synthesized through coordination between tannic acid and Fe3+, loaded with anti-TNF- α siRNA and then modified with bovine serum albumin. The nanosystem can selectively accumulate in inflamed joints, be selectively delivered into M1 macrophages, and exert anti-RA efficacy through the synergistic effects between MOF vector and anti-TNF-α siRNA. AbstractMacrophages play essential roles in the progression of rheumatoid arthritis (RA), which are polarized into the pro-inflammatory M1 phenotype with significant oxidative stress and cytokines excretion. Here...
Source: Small - June 3, 2022 Category: Nanotechnology Authors: Lina Guo, Shenghui Zhong, Peng Liu, Man Guo, Jinsong Ding, Wenhu Zhou Tags: Research Article Source Type: research

Modular Lipid Nanoparticle Platform Technology for siRNA and Lipophilic Prodrug Delivery
Lipid nanoparticles (LNPs) are the most advanced nanocarriers for nucleic acid therapeutics such as small interfering RNA (siRNA). Here, it is showcased how LNP technology's modularity and the ability to stably incorporate lipophilic small molecule prodrugs provide ample opportunities to develop combination therapies by co-encapsulating multiple therapeutic agents in a single formulation. AbstractSuccessfully employing small interfering RNA (siRNA) therapeutics requires the use of nanotechnology for efficient intracellular delivery. Lipid nanoparticles (LNPs) have enabled the approval of various nucleic acid therapeutics. ...
Source: Small - August 2, 2021 Category: Nanotechnology Authors: Roy Meel, Sam Chen, Josh Zaifman, Jayesh A. Kulkarni, Xu Ran S. Zhang, Ying K. Tam, Marcel B. Bally, Raymond M. Schiffelers, Marco A. Ciufolini, Pieter R. Cullis, Yuen Yi C. Tam Tags: Research Article Source Type: research