Filtered By:
Source: Molecular and Cellular Endocrinology
This page shows you your search results in order of date. This is page number 5.
Order by Relevance | Date
Total 76 results found since Jan 2013.
Dihydromyricetin stimulates irisin secretion partially via the PGC-1α pathway
Publication date: 5 September 2015 Source:Molecular and Cellular Endocrinology, Volume 412 Author(s): Qicheng Zhou, Ka Chen, Peng Liu, Yanxiang Gao, Dan Zou, Huiling Deng, Yujie Huang, Qianyong Zhang, Jundong Zhu, Mantian Mi Irisin, derived from FNDC5, is an exercise-induced myokine that can stimulate the ‘browning’ of white adipose tissue, which is regulated by peroxisome proliferator-activated receptor γ coactivator 1 α (PGC-1α). Dihydromyricetin (DHM), a natural flavonoid, exerts its activities through PGC-1α activation. Here, we explored whether DHM could mimic the effects of exercise on irisin secr...
Source: Molecular and Cellular Endocrinology - July 24, 2015 Category: Endocrinology Source Type: research
1,25-Dihydroxyvitamin D3 and extracellular calcium promote mineral deposition via NPP1 activity in a mature osteoblast cell line MLO-A5
Publication date: 5 September 2015 Source:Molecular and Cellular Endocrinology, Volume 412 Author(s): Dongqing Yang , Andrew G. Turner , Asiri R. Wijenayaka , Paul H. Anderson , Howard A. Morris , Gerald J. Atkins While vitamin D supplementation is common, the anabolic mechanisms that improve bone status are poorly understood. Under standard mineralising conditions including media ionised calcium of 1.1 mM, 1,25-dihydroxyvitamin D3 (1,25D) enhanced differentiation and mineral deposition by the mature osteoblast/pre-osteocyte cell line, MLO-A5. This effect was markedly increased with a higher ionised calcium level (1.5â...
Source: Molecular and Cellular Endocrinology - June 26, 2015 Category: Endocrinology Source Type: research
Fatty Acid-Binding Protein 4 mediates apoptosis via endoplasmic reticulum stress in mesangial cells of diabetic nephropathy
Publication date: 15 August 2015 Source:Molecular and Cellular Endocrinology, Volume 411 Author(s): Fang Yao , Zhen Li , Takashi Ehara , Lin Yang , Dandan Wang , Lulu Feng , Yiming Zhang , Kun Wang , Yonghong Shi , Huijun Duan , Lianshan Zhang Type 2 diabetes is characterized by hyperglycemia and deregulated lipid metabolism with increased plasma non-esterified fatty acids (NEFA). Apoptosis of glomerular cells is a hallmark in diabetic glomerulosclerosis. Fatty acid-binding protein 4 (FABP4), a carrier protein for fatty acids, has been linked to diabetes and diabetic nephropathy (DN). Here we aimed to investigate the lin...
Source: Molecular and Cellular Endocrinology - June 26, 2015 Category: Endocrinology Source Type: research
Dihydromyricetin improves skeletal muscle insulin resistance by inducing autophagy via the AMPK signaling pathway
In conclusion, DHM improved SMIR by inducing autophagy via the activation of AMPK signaling pathway.
Source: Molecular and Cellular Endocrinology - March 20, 2015 Category: Endocrinology Source Type: research
Transmembrane tumor necrosis factor-alpha sensitizes adipocytes to insulin
Publication date: 5 May 2015 Source:Molecular and Cellular Endocrinology, Volume 406 Author(s): Wenjing Zhou , Peng Yang , Li Liu , Shan Zheng , Qingling Zeng , Huifang Liang , Yazhen Zhu , Zunyue Zhang , Jing Wang , Bingjiao Yin , Feili Gong , Yiping Wu , Zhuoya Li Transmembrane TNF-α (tmTNF-α) acts both as a ligand, delivering ‘forward signaling’ via TNFR, and as a receptor, transducing ‘reverse signaling’. The contradiction of available data regarding the effect of tmTNF-α on insulin resistance may be due to imbalance in both signals. Here, we demonstrated that high glucose-induced impairment of insulin-sti...
Source: Molecular and Cellular Endocrinology - March 10, 2015 Category: Endocrinology Source Type: research
Glycated albumin triggers fibrosis and apoptosis via an NADPH oxidase/Nox4-MAPK pathway-dependent mechanism in renal proximal tubular cells
In this study, we investigated the effects of GA on fibrosis and apoptosis of renal proximal tubular cells (NRK-52E) in vitro experiments. Our results showed that GA promoted α-SMA, fibronectin (FN) and TGF-β expressions in NRK-52E cells. GA also increased cell apoptosis and stimulated the expressions of pro-caspase 3/cleaved-caspase 3. GA overloading enhanced the phosphorylation of MAPK pathway. GA-induced α-SMA, FN, TGF-β and caspase 3 expressions were completely suppressed by the NADPH oxidase inhibitor apocynin (Apo), the reactive oxygen species (ROS) scavenger N-acetylcysteine (NAC) and the latent antioxidant Astr...
Source: Molecular and Cellular Endocrinology - March 10, 2015 Category: Endocrinology Source Type: research
MMP2 and MMP9 participate in S1P-induced invasion of follicular ML-1 thyroid cancer cells
In conclusion, MMP2 and MMP9 participate in S1P-evoked follicular ML-1 thyroid cancer cell invasion.
Source: Molecular and Cellular Endocrinology - March 10, 2015 Category: Endocrinology Source Type: research
Pulsed electromagnetic fields promote osteoblast mineralization and maturation needing the existence of primary cilia
Publication date: 15 March 2015 Source:Molecular and Cellular Endocrinology, Volume 404 Author(s): Juan-Li Yan , Jian Zhou , Hui-Ping Ma , Xiao-Ni Ma , Yu-Hai Gao , Wen-Gui Shi , Qing-Qing Fang , Qian Ren , Cory J. Xian , Ke-Ming Chen Although pulsed electromagnetic fields (PEMFs) have been approved as a therapy for osteoporosis, action mechanisms and optimal parameters are elusive. To determine the optimal intensity, exposure effects of 50 Hz PEMFs of 0.6–3.6 mT (0.6 interval at 90 min/day) were investigated on proliferation and osteogenic differentiation of cultured calvarial osteoblasts. All intensity groups sti...
Source: Molecular and Cellular Endocrinology - March 10, 2015 Category: Endocrinology Source Type: research
Inhibition of prolyl hydroxylase 3 ameliorates cardiac dysfunction in diabetic cardiomyopathy
Publication date: 5 March 2015 Source:Molecular and Cellular Endocrinology, Volume 403 Author(s): Yanfei Xia , Luwei Gong , Hui Liu , Beibei Luo , Bo Li , Rui Li , Beibei Li , Mei Lv , Jinyu Pan , Fengshuang An Prolyl hydroxylase 3 (PHD3) is a member of the prolyl hydroxylases (PHDs) family and is induced by hypoxia. It plays a critical role in regulating the abundance of hypoxia-inducible factor (HIF). Its expression is increased in diabetic rat hearts; however, its role remains unclear. We investigated the potential role and mechanism of action of PHD3 in the setting of diabetes-induced myocardial dysfunction in rats. ...
Source: Molecular and Cellular Endocrinology - January 27, 2015 Category: Endocrinology Source Type: research
NF-κB increased expression of 17β-hydroxysteroid dehydrogenase 4 promotes HepG2 proliferation via inactivating estradiol
In this study, HepG2 cells were used to investigate the role of HSD17B4 in the proliferation of liver cancer cells treated with the NF-κB activator, tumor necrosis factor-alpha (TNF-α), with the inhibitor of NF-κB activation, pyrrolidinedithiocarbamate (PDTC), or with a related specific siRNA. We demonstrated that the human HSD17B4 gene is a target for NF-κB activation in inflammation-stimulated HepG2 cells. HSD17B4 is up-regulated via the binding of activated NF-κB to the distal NF-κB-responsive element via TNF-α stimulation, which then promotes cell proliferation by decreasing the levels of E2 and enhancing the ex...
Source: Molecular and Cellular Endocrinology - December 12, 2014 Category: Endocrinology Source Type: research
Palmitoleic acid prevents palmitic acid-induced macrophage activation and consequent p38 MAPK-mediated skeletal muscle insulin resistance
Publication date: 5 August 2014 Source:Molecular and Cellular Endocrinology, Volume 393, Issues 1–2 Author(s): Nicola A. Talbot , Caroline P. Wheeler-Jones , Mark E. Cleasby Obesity and saturated fatty acid (SFA) treatment are both associated with skeletal muscle insulin resistance (IR) and increased macrophage infiltration. However, the relative effects of SFA and unsaturated fatty acid (UFA)-activated macrophages on muscle are unknown. Here, macrophages were treated with palmitic acid, palmitoleic acid or both and the effects of the conditioned medium (CM) on C2C12 myotubes investigated. CM from palmitic acid-treated...
Source: Molecular and Cellular Endocrinology - November 23, 2014 Category: Endocrinology Source Type: research
Oxytocin activates NF-κB-mediated inflammatory pathways in human gestational tissues
Publication date: Available online 14 November 2014 Source:Molecular and Cellular Endocrinology Author(s): Sung Hye Kim , David A. MacIntyre , Maria Firmino Da Silva , Andrew M. Blanks , Yun S Lee , Steven Thornton , Phillip R. Bennett , Vasso Terzidou Human labor, both at term and preterm, is preceded by NF-κB-mediated inflammatory activation within the uterus leading to myometrial activation, fetal membrane remodelling and cervical ripening. The stimuli triggering inflammatory activation in normal human parturition are not fully understood. We show that the neurohypophyseal peptide, oxytocin (OT), activates NF-κB and...
Source: Molecular and Cellular Endocrinology - November 14, 2014 Category: Endocrinology Source Type: research
Involvement of insulin-like growth factor binding protein-3 in peroxisome proliferator-activated receptor gamma-mediated inhibition of breast cancer cell growth
Publication date: 5 January 2015 Source:Molecular and Cellular Endocrinology, Volume 399 Author(s): Cindy K. Pon , Sue M. Firth , Robert C. Baxter We have previously reported that insulin-like growth factor binding protein-3 (IGFBP-3), a protein with dichotomous effects on both cell proliferation and cell survival, interacts with peroxisome proliferator-activated receptor gamma (PPARγ) and inhibits adipogenic PPARγ signaling. We now show that IGFBP-3 and PPARγ interact in breast cancer cells, through amino- and carboxyl-terminal residues of IGFBP-3. IGFBP-3 and the PPARγ ligands, rosiglitazone or 15-deoxy-Δ12,14-pro...
Source: Molecular and Cellular Endocrinology - November 13, 2014 Category: Endocrinology Source Type: research
Estrogen mediated epithelial proliferation in the uterus is directed by stromal Fgf10 and Bmp8a
Publication date: Available online 7 November 2014 Source:Molecular and Cellular Endocrinology Author(s): Daesuk Chung , Fei Gao , Anil G. Jegga , Sanjoy K. Das To define endometrial stromal-derived paracrine mediators that participate in estradiol-17β (E2)-induced epithelial proliferation, microarray analysis of gene expression was carried out in mouse uterine epithelial-stromal co-culture systems under the condition of E2 or vehicle (control). Our results demonstrated gene alteration by E2: in epithelial cells, we found up-regulation of 119 genes and down-regulation of 28 genes, while in stroma cells we found up-regul...
Source: Molecular and Cellular Endocrinology - November 7, 2014 Category: Endocrinology Source Type: research
Involvement of insulin-like growth factor binding protein-3 in peroxisome proliferator activated receptor gamma-mediated inhibition of breast cancer cell growth
Publication date: Available online 31 October 2014 Source:Molecular and Cellular Endocrinology Author(s): Cindy K. Pon , Sue M. Firth , Robert C. Baxter We have previously reported that insulin-like growth factor binding protein-3 (IGFBP-3), a protein with dichotomous effects on both cell proliferation and cell survival, interacts with peroxisome proliferator-activated receptor gamma (PPARγ) and inhibits adipogenic PPARγ signaling. We now show that IGFBP-3 and PPARγ interact in breast cancer cells, through amino- and carboxyl-terminal residues of IGFBP-3. IGFBP-3 and the PPARγ ligands, rosiglitazone or 15-deoxy-Δ12,...
Source: Molecular and Cellular Endocrinology - November 3, 2014 Category: Endocrinology Source Type: research
