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Source: Molecular and Cellular Endocrinology
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Total 76 results found since Jan 2013.
Endoglin (CD105) coordinates the process of endometrial receptivity for embryo implantation
In conclusion, our findings reveal the association of endoglin with endometrial receptivity, which is important for embryo attachment.
Source: Molecular and Cellular Endocrinology - January 21, 2016 Category: Endocrinology Source Type: research
Increased IGFBP-1 phosphorylation in response to leucine deprivation is mediated by CK2 and PKC
Publication date: Available online 28 December 2015 Source:Molecular and Cellular Endocrinology Author(s): Niyati Malkani, Kyle Biggar, Majida Abu Shehab, Shawn Li, Thomas Jansson, Madhulika B. Gupta Insulin-like growth factor binding protein-1 (IGFBP-1), secreted by fetal liver, is a key regulator of IGF-I bioavailability and fetal growth. IGFBP-1 phosphorylation decreases IGF-I bioavailability and diminishes its growth-promoting effects. Growth-restricted fetuses have decreased levels of circulating essential amino acids. We recently showed that IGFBP-1 hyperphosphorylation (pSer101/119/169) in response to leucin...
Source: Molecular and Cellular Endocrinology - December 28, 2015 Category: Endocrinology Source Type: research
Melatonin enhances arsenic trioxide-induced cell death via sustained upregulation of Redd1 expression in breast cancer cells
Publication date: Available online 27 November 2015 Source:Molecular and Cellular Endocrinology Author(s): Sun-Mi Yun, Sang Hyeok Woo, Sang Taek Oh, Sung-Eun Hong, Tae-Boo Choe, Sang-Kyu Ye, Eun-Kyu Kim, Min Ki Seong, Hyun-A Kim, Woo Chul Noh, Jin Kyung Lee, Hyeon-Ok Jin, Yun-Han Lee, In-Chul Park Melatonin is implicated in various physiological functions, including anticancer activity. However, the mechanism(s) of its anticancer activity is not well understood. In the present study, we investigated the combined effects of melatonin and arsenic trioxide (ATO) on cell death in human breast cancer cells. Mela...
Source: Molecular and Cellular Endocrinology - November 27, 2015 Category: Endocrinology Source Type: research
Epidermal Growth Factor: Porcine Uterine Luminal Epithelial Cell Migratory Signal during the Peri-implantation Period of Pregnancy
Publication date: Available online 24 November 2015 Source:Molecular and Cellular Endocrinology Author(s): Wooyoung Jeong, Seoungo Jung, Fuller W. Bazer, Gwonhwa Song, Jinyoung Kim The majority of early conceptus mortality in pregnancy occurs during the peri-implantation period, suggesting that this period is important for conceptus viability and the establishment of pregnancy. Successful establishment of pregnancy in all mammalian species depends on the orchestrated molecular events that transpire at the conceptus-uterine interface during the peri-implantation period of pregnancy. This maternal-conceptus interactio...
Source: Molecular and Cellular Endocrinology - November 24, 2015 Category: Endocrinology Source Type: research
TRAF2 mediates JNK and STAT3 activation in response to IL-1β and IFNγ and facilitates apoptotic death of insulin-producing β-cells
Publication date: Available online 22 November 2015 Source:Molecular and Cellular Endocrinology Author(s): Michala Cecilie Prause, Lukas Adrian Berchtold, Adriana Ibarra Urizar, Anne Mette Hyldgaard Trauelsen, Nils Billestrup, Thomas Mandrup-Poulsen, Joachim Størling Interleukin-1β (IL-1β) and interferon-γ (IFNγ) contribute to type 1 diabetes (T1D) by inducing β-cell death. Tumor necrosis factor (TNF) receptor-associated factor (TRAF) proteins are adaptors that transduce signaling from a variety of membrane receptors including cytokine receptors. We show here that IL-1β and IFNγ upregulate the expression o...
Source: Molecular and Cellular Endocrinology - November 23, 2015 Category: Endocrinology Source Type: research
Estrogen suppresses breast cancer proliferation through GPER / p38 MAPK axis during hypoxia
In conclusion, Estrogen suppresses breast cancer growth by inhibiting G1/S phase transition through GPER/ROS/p38 MAPK/p21 mediated signaling during hypoxic condition.
Source: Molecular and Cellular Endocrinology - November 6, 2015 Category: Endocrinology Source Type: research
C1q/TNF-related protein-9 inhibits cytokine-induced vascular inflammation and leukocyte adhesiveness via AMP-activated protein kinase activation in endothelial cells
Publication date: Available online 31 October 2015 Source:Molecular and Cellular Endocrinology Author(s): Chang Hee Jung, Min Jung Lee, Yu Mi Kang, Yoo La Lee, So Mi Seol, Hae Kyeong Yoon, Sang-Wook Kang, Woo Je Lee, Joong-Yeol Park Although recent studies have reported cardioprotective effects of C1q/TNF-related protein 9 (CTRP9), the closet adiponectin paralog, its role on cytokine-induced endothelial inflammation is unknown. We investigated whether CTRP9 prevented inflammatory cytokine-induced nuclear factor-kappa B (NF-κB) activation and inhibited the expression of adhesion molecules and a chemokine in the ...
Source: Molecular and Cellular Endocrinology - October 31, 2015 Category: Endocrinology Source Type: research
Ghrelin regulates GLP-1 production through mTOR signaling in L cells
Publication date: 15 November 2015 Source:Molecular and Cellular Endocrinology, Volume 416 Author(s): Geyang Xu, Xiaosi Hong, Hong Tang, Sushi Jiang, Fenting Liu, Zhemin Shen, Ziru Li, Weizhen Zhang Glucagon-like peptide (GLP-1), an intestinal incretin produced in L-cells and released in response to meal intake, functions to promote insulin secretion and to decrease plasma glucose. Ghrelin is an orexigenic hormone critical for glucose homeostasis. The molecular mechanism by which ghrelin alters GLP-1 production remains largely unknown. Here we showed that ghrelin attenuates GLP-1 production through mTOR signaling...
Source: Molecular and Cellular Endocrinology - October 14, 2015 Category: Endocrinology Source Type: research
AMP-activated protein kinase suppresses the expression of LXR/SREBP-1 signaling-induced ANGPTL8 in HepG2 cells
Publication date: 15 October 2015 Source:Molecular and Cellular Endocrinology, Volume 414 Author(s): Jinmi Lee, Seok-Woo Hong, Se Eun Park, Eun-Jung Rhee, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Won-Young Lee ANGPTL8 is a liver-derived secretory protein that leads to elevated serum triglyceride and the level of circulating ANGPTL8 is strongly associated with obesity and diabetes. Here we investigated the mechanisms of activation and inhibition of ANGPTL8 expression in hepatocytes. The expression of ANGPTL8 was significantly increased in HepG2 cells exposed to palmitic acid, tunicamycin, or T0901317, and was r...
Source: Molecular and Cellular Endocrinology - August 8, 2015 Category: Endocrinology Source Type: research
Expression, regulation and function of Hmgn3 during decidualization in mice
Publication date: 15 September 2015 Source:Molecular and Cellular Endocrinology, Volume 413 Author(s): Dang-Dang Li, Chuan-Hui Guo, Liang Yue, Cui-Cui Duan, Zhan-Qing Yang, Hang Cao, Bin Guo, Zhan-Peng Yue Although Hmgn3 is involved in the regulation of development and cellular differentiation, its physiological roles on decidualization are still unknown. Here we showed that Hmgn3 was highly expressed in the decidua and decidualizing stromal cells. Overexpression of Hmgn3 variants, Hmgn3a or Hmgn3b, enhanced the expression of decidualization markers Prl8a2 and Prl3c1, whereas inhibition of Hmgn3 reduced their exp...
Source: Molecular and Cellular Endocrinology - July 31, 2015 Category: Endocrinology Source Type: research
Rosiglitazone inhibition of calvaria-derived osteoblast differentiation is through both of PPARγ and GPR40 and GSK3β-dependent pathway
This study aims to investigate the effects of RSG on differentiation and mineralization of osteoblasts using primary cultured mouse fetal calvaria-derived osteoblasts as a model, and elucidate the receptor and signaling pathways responsible for these effects. We found that RSG suppressed the differentiation and mineralization of calvaria-derived osteoblasts. Peroxisome proliferators-activated receptor γ (PPARγ) siRNA significantly reversed the inhibitory effect of RSG on osteogenic differentiation. The expression of G protein-coupled receptor (GPR) 40 was suppressed during differentiation, but was increased by RSG treatm...
Source: Molecular and Cellular Endocrinology - July 31, 2015 Category: Endocrinology Source Type: research
Molecular mechanisms underlying oxytocin-induced cardiomyocyte protection from simulated ischemia–reperfusion
In conclusion, the OTR protected H9c2 cells against I–R, especially if activated at the onset of ischemia or reperfusion. The OTR-transduced signals include pro-survival kinases, such as Akt and PKG.
Source: Molecular and Cellular Endocrinology - July 24, 2015 Category: Endocrinology Source Type: research
IGFBP-1 hyperphosphorylation in response to leucine deprivation is mediated by the AAR pathway
Publication date: 5 September 2015 Source:Molecular and Cellular Endocrinology, Volume 412 Author(s): Niyati Malkani, Thomas Jansson, Madhulika B. Gupta Insulin-like growth factor-1 (IGF-I) is the key regulator of fetal growth. IGF-I bioavailability is markedly diminished by IGF binding protein-1 (IGFBP-1) phosphorylation. Leucine deprivation strongly induces IGFBP-1 hyperphosphorylation, and plays an important role in fetal growth restriction (FGR). FGR is characterized by decreased amino acid availability, which activates the amino acid response (AAR) and inhibits the mechanistic target of rapamycin (mTOR) pathway. ...
Source: Molecular and Cellular Endocrinology - July 24, 2015 Category: Endocrinology Source Type: research
X-linked lymphocyte regulated gene 5c-like (Xlr5c-like) is a novel target of progesterone action in granulosa cells of periovulatory rat ovaries
In conclusion, this is the first report showing the spatiotemporally regulated expression of Xlr5c-like mRNA by hCG in rat periovulatory ovaries. P4/PGR mediates the LH-induced increase in Xlr5c-like mRNA. In turn, Xlr5c-like is involved in regulating the expression of specific ovulatory genes such as Snap25, Cxcr4, and Adamts1, possibly acting in the nucleus of periovulatory granulosa cells.
Source: Molecular and Cellular Endocrinology - July 24, 2015 Category: Endocrinology Source Type: research
Preadipocyte proliferation is elevated by calcium sensing receptor activation
This study evaluated whether CaSR activation elevates preadipocyte proliferation. Human LS14 preadipocytes were exposed to CaSR activators cinacalcet (2 µM), GdCl3 (5 µM) and spermine (1 µM), and cell viability was evaluated after 72h. CaSR activators elevated proliferation by 19–24%, and CaSR silencing (siRNA) abolished the effect. Cinacalcet elevated phospho-ERK1/2 content, and upstream inhibition of ERK1/2 phosphorylation reverted cinacalcet-induced proliferation. Cinacalcet also elevated expression of the proinflammatory factors IL1β, IL6 and CCL2. The results suggest that CaSR induces preadipocyte prolifer...
Source: Molecular and Cellular Endocrinology - July 24, 2015 Category: Endocrinology Source Type: research
