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Source: Molecular and Cellular Endocrinology
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Total 76 results found since Jan 2013.
Estrogen receptor beta signaling inhibits PDGF induced human airway smooth muscle proliferation
In this study, we evaluated the effect of selective ERα and ERβ modulators on platelet-derived growth factor (PDGF)-stimulated ASM proliferation and the mechanisms involved. Asthmatic and non-asthmatic primary human ASM cells were treated with PDGF, 17β-estradiol, ERα-agonist and/or ERβ-agonist and/or G-protein-coupled estrogen receptor 30 (GPR30/GPER) agonist and proliferation was measured using MTT and CyQuant assays followed by cell cycle analysis. Transfection of small interfering RNA (siRNA) ERα and ERβ significantly altered the human ASM proliferation. The specificity of siRNA transfection was confirmed by Wes...
Source: Molecular and Cellular Endocrinology - July 10, 2018 Category: Endocrinology Source Type: research
Intestinal CART is a regulator of GIP and GLP-1 secretion and expression
Publication date: Available online 6 April 2018Source: Molecular and Cellular EndocrinologyAuthor(s): L. Shcherbina, A. Lindqvist, A.-H. Thorén Fischer, E. Ahlqvist, E. Zhang, S.E. Falkmer, E. Renström, J. Koffert, H. Honka, N. WierupAbstractImpaired incretin effect is a culprit in Type 2 Diabetes. Cocaine- and amphetamine-regulated transcript (CART) is a regulatory peptide controlling pancreatic islet hormone secretion and beta-cell survival. Here we studied the potential expression of CART in enteroendocrine cells and examined the role of CART as a regulator of incretin secretion and expression.CART expression was foun...
Source: Molecular and Cellular Endocrinology - July 10, 2018 Category: Endocrinology Source Type: research
Vitamin D suppresses macrophage infiltration by down-regulation of TREM-1 in diabetic nephropathy rats
This study intends to investigate the effect of active vitamin D (VD) on the expression of triggering receptor expressed on myeloid cells-1 (TREM-1) in the renal tissues of diabetic nephropathy (DN) rats and to explore the impact of TREM-1 on macrophage adhesion and migration. We find that the expressions of TREM-1 and CD68 protein are higher in DN rats compared with rats in the normal control group and that these changes are decreased in the DN + VD group. In vitro, the capacity for macrophage adhesion and migration and the expression of TREM-1 are increased under high-glucose conditions, but VD inhibits this progress....
Source: Molecular and Cellular Endocrinology - July 10, 2018 Category: Endocrinology Source Type: research
Oxytocin alters the morphology of hypothalamic neurons via the transcription factor myocyte enhancer factor 2A (MEF-2A)
In this study, we present evidence for three hypotheses: 1) OT leads to neurite retraction in hypothalamic neurons via the OT receptor (OTR) 2) The transcription factor MEF-2A is a central regulator of OT-induced neurite retraction, and 3) The MAPK pathway is critical for OT-induced MEF-2A activation.Incubation of rat hypothalamic H32 cells with 10 nM to 1 μM OT, vasopressin, and the specific OTR agonist TGOT, over the course of 12 h resulted in a time-dependent, significant retraction of neurites. In addition, the size of the nuclear compartment increased, whereas the overall cell size remained unchanged. OT trea...
Source: Molecular and Cellular Endocrinology - July 5, 2018 Category: Endocrinology Source Type: research
Estrogen receptor beta signaling inhibits PDGF induced human airway smooth muscle proliferation
In this study, we evaluated the effect of selective ERα and ERβ modulators on platelet-derived growth factor (PDGF)-stimulated ASM proliferation and the mechanisms involved. Asthmatic and non-asthmatic primary human ASM cells were treated with PDGF, 17β-estradiol, ERα-agonist and/or ERβ-agonist and/or G-protein-coupled estrogen receptor 30 (GPR30/GPER) agonist and proliferation was measured using MTT and CyQuant assays followed by cell cycle analysis. Transfection of small interfering RNA (siRNA) ERα and ERβ significantly altered the human ASM proliferation. The specificity of siRNA transfection was confirmed by Wes...
Source: Molecular and Cellular Endocrinology - July 5, 2018 Category: Endocrinology Source Type: research
Intestinal CART is a regulator of GIP and GLP-1 secretion and expression
Publication date: Available online 6 April 2018Source: Molecular and Cellular EndocrinologyAuthor(s): L. Shcherbina, A. Lindqvist, A.-H. Thorén Fischer, E. Ahlqvist, E. Zhang, S.E. Falkmer, E. Renström, J. Koffert, H. Honka, N. WierupAbstractImpaired incretin effect is a culprit in Type 2 Diabetes. Cocaine- and amphetamine-regulated transcript (CART) is a regulatory peptide controlling pancreatic islet hormone secretion and beta-cell survival. Here we studied the potential expression of CART in enteroendocrine cells and examined the role of CART as a regulator of incretin secretion and expression.CART expression was foun...
Source: Molecular and Cellular Endocrinology - July 5, 2018 Category: Endocrinology Source Type: research
SIRT1 suppresses high glucose and palmitate-induced osteoclast differentiation via deacetylating p66Shc
In conclusion, this study confirms the role of DM in osteoclast differentiation in vitro. SIRT1 suppresses HG- and PA-induced osteoclast differentiation via p66Shc/ROS/NF-κB signaling.
Source: Molecular and Cellular Endocrinology - July 5, 2018 Category: Endocrinology Source Type: research
Regulation of NADPH oxidase NOX4 by delta iodolactone (IL- δ) in thyroid cancer cells
Conclusions The antiproliferative and pro-apoptotic effect of IL-δ is mediated by different mechanisms and pathway involving different sources of ROS generation depending on the cellular context. Graphical abstract
Source: Molecular and Cellular Endocrinology - May 27, 2018 Category: Endocrinology Source Type: research
Estrogen receptor beta signaling inhibits PDGF induced human airway smooth muscle proliferation
In this study, we evaluated the effect of selective ERα and ERβ modulators on platelet-derived growth factor (PDGF)-stimulated ASM proliferation and the mechanisms involved. Asthmatic and non-asthmatic primary human ASM cells were treated with PDGF, 17β-estradiol, ERα-agonist and/or ERβ-agonist and/or G-protein-coupled estrogen receptor 30 (GPR30/GPER) agonist and proliferation was measured using MTT and CyQuant assays followed by cell cycle analysis. Transfection of small interfering RNA (siRNA) ERα and ERβ significantly altered the human ASM proliferation. The specificity of siRNA transfection was confirmed by Wes...
Source: Molecular and Cellular Endocrinology - April 20, 2018 Category: Endocrinology Source Type: research
Intestinal CART is a regulator of GIP and GLP-1 secretion and expression
Publication date: Available online 6 April 2018 Source:Molecular and Cellular Endocrinology Author(s): L. Shcherbina, A. Lindqvist, A.-H. Thorén Fischer, E. Ahlqvist, E. Zhang, S.E. Falkmer, E. Renström, J. Koffert, H. Honka, N. Wierup Impaired incretin effect is a culprit in Type 2 Diabetes. Cocaine- and amphetamine-regulated transcript (CART) is a regulatory peptide controlling pancreatic islet hormone secretion and beta-cell survival. Here we studied the potential expression of CART in enteroendocrine cells and examined the role of CART as a regulator of incretin secretion and expression. CART expression was found in...
Source: Molecular and Cellular Endocrinology - April 7, 2018 Category: Endocrinology Source Type: research
SIRT1 suppresses high glucose and palmitate-induced osteoclast differentiation via deacetylating p66Shc
In conclusion, this study confirms the role of DM in osteoclast differentiation in vitro. SIRT1 suppresses HG- and PA-induced osteoclast differentiation via p66Shc/ROS/NF-κB signaling.
Source: Molecular and Cellular Endocrinology - February 25, 2018 Category: Endocrinology Source Type: research
MXRA5 is decreased in preeclampsia and affects trophoblast cell invasion through the MAPK pathway
This study sought to explore the role of MXRA5 in trophoblast cell invasion. Preeclamptic villi were obtained for the delineation of MXRA5 expression. Specific MXRA5 siRNA and pcDNA3.1/MXRA5 were used to manipulate MXRA5 expression in HTR-8/SVneo. Cell viability was determined by MTT and apoptosis by flow cytometry. Cell invasion was evaluated using Matrigel invasion assay. MXRA5 expression was lower in preeclamptic villi and cytotrophoblasts. Silencing MXRA5 expression in HTR-8/SVneo decreased cell viability and invasion, which were augmented by MXRA5 overexpression. Furthermore, MXRA5 modulated N-cadherin, E-cadherin, MM...
Source: Molecular and Cellular Endocrinology - January 29, 2018 Category: Endocrinology Source Type: research
Hyperlipidemia-induced hepassocin in the liver contributes to insulin resistance in skeletal muscle
In conclusion, we elucidated that ER stress induced by palmitate could increase the expression of HPS in hepatocytes and further contribute to the development of insulin resistance in skeletal muscle via EGFR/JNK-mediated pathway. Taken together, we suggest that HPS could be a therapeutic target for obesity-linked insulin resistance. Graphical abstract
Source: Molecular and Cellular Endocrinology - October 28, 2017 Category: Endocrinology Source Type: research
Bazedoxifene and raloxifene protect neocortical neurons undergoing hypoxia via targeting ER α and PPAR-γ
This study provides prospects for the development of a new therapeutic strategies against hypoxic brain injury that selectively target ERα and/or PPAR-γ.
Source: Molecular and Cellular Endocrinology - August 31, 2017 Category: Endocrinology Source Type: research
Lactate induces osteoblast differentiation by stabilization of HIF1 α
Publication date: Available online 20 May 2017 Source:Molecular and Cellular Endocrinology Author(s): Yu Wu, Miaomiao Wang, Haihua Feng, Ying Peng, Jieyun Sun, Xiuxia Qu, Chunping Li Aerobic glycolysis is involved in osteoblast differentiation induced by Wnt signaling or PTH treatment. However, it is still unclear whether lactate, the end product of aerobic glycolysis, plays any role in osteoblast differentiation. Herein we report that in cultures of osteoblast-lineage cells, lactate promoted alkaline phosphatase-positive cell formation, increased the activity of alkaline phosphatase, and induced the expression of osteoca...
Source: Molecular and Cellular Endocrinology - May 21, 2017 Category: Endocrinology Source Type: research
