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Source: Autophagy
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Total 127 results found since Jan 2013.
Increased alveolar epithelial TRAF6 via autophagy-dependent TRIM37 degradation mediates particulate matter-induced lung metastasis
Autophagy. 2021 Sep 15:1-19. doi: 10.1080/15548627.2021.1965421. Online ahead of print.ABSTRACTEpidemiological and clinical studies have shown that exposure to particulate matter (PM) is associated with an increased incidence of lung cancer and metastasis. However, the underlying mechanism remains unclear. Here, we demonstrated the central role of PM-induced neutrophil recruitment in promoting lung cancer metastasis. We found that reactive oxygen species (ROS)-mediated alveolar epithelial macroautophagy/autophagy was essential for initiating neutrophil chemotaxis and pre-metastatic niche formation in the lungs in response ...
Source: Autophagy - September 15, 2021 Category: Cytology Authors: Jiajun Liu Shumin Li Xuefeng Fei Xi Nan Yingying Shen Huiqing Xiu Stephania A Cormier Chaojie Lu Chuqi Guo Shibo Wang Zhijian Cai Pingli Wang Source Type: research
MEF2D-NR4A1-FAM134B2-mediated reticulophagy contributes to amino acid homeostasis
In conclusion, the MEF2D-NR4A1-FAM134B2 cascade is a critical signal in amino acid homeostasis.PMID:34517786 | DOI:10.1080/15548627.2021.1968228
Source: Autophagy - September 14, 2021 Category: Cytology Authors: Yuji Shiozaki Shinobu Miyazaki-Anzai Audrey L Keenan Makoto Miyazaki Source Type: research
Exendin-4 stimulates autophagy in pancreatic β-cells via the RAPGEF/EPAC-Ca < sup > 2+ < /sup > -PPP3/calcineurin-TFEB axis
Autophagy. 2021 Aug 2:1-17. doi: 10.1080/15548627.2021.1956123. Online ahead of print.ABSTRACTMacroautophagy/autophagy is critical for the regulation of pancreatic β-cell mass and its deregulation has been implicated in the pathogenesis of type 2 diabetes (T2D). We have previously shown that treatment of pancreatic β-cells with the GLP1R (glucagon like peptide 1 receptor) agonist exendin-4 stimulates autophagic flux in a setting of chronic nutrient excess. The aim of this study was to identify the underlying pathways contributing to enhanced autophagic flux.Pancreatic β-cells (INS-1E),mouse and human islets were treated...
Source: Autophagy - August 2, 2021 Category: Cytology Authors: Francesco P Zummo Stanislaus I Krishnanda Merilin Georgiou Finbarr Pm O'Harte Vadivel Parthsarathy Kirsty S Cullen Minna Honkanen-Scott James Am Shaw Penny E Lovat Catherine Arden Source Type: research
CCDC88A/GIV promotes HBV replication and progeny secretion via enhancing endosomal trafficking and blocking autophagic degradation
In conclusion, CCDC88A/GIV enhanced HBV replication by increasing endosomal trafficking and reducing autophagic degradation of HBV antigens, suggesting that CCDC88A/GIV-mediated endosomal trafficking plays an important role in HBV replication and progeny secretion.AbbreviationsACTB: actin beta; AO: acridine orange; ATF6: activating transcription factor 6; CCDC88A/GIV: coiled-coil domain containing 88A; CLTC: clathrin heavy chain; CQ: chloroquine; DAPI: 4',6-diamidino-2-phenylindole; DNM2: dynamin 2; ER: endoplasmic reticulum; ERN1: endoplasmic reticulum to nucleus signaling 1; EIF2A: eukaryotic translation initiation facto...
Source: Autophagy - June 30, 2021 Category: Cytology Authors: Xueyu Wang Zhiqiang Wei Tingyu Lan Yulin He Bin Cheng Ruimin Li Hongxia Chen Fahong Li Guohua Liu Bin Jiang Yong Lin Mengji Lu Zhongji Meng Source Type: research
