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Source: Autophagy
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Total 127 results found since Jan 2013.
Tegument protein UL21 of alpha-herpesvirus inhibits the innate immunity by triggering CGAS degradation through TOLLIP-mediated selective autophagy
Autophagy. 2022 Nov 7:1-21. doi: 10.1080/15548627.2022.2139921. Online ahead of print.ABSTRACTAlpha-herpesvirus causes lifelong infections and serious diseases in a wide range of hosts and has developed multiple strategies to counteract the host defense. Here, we demonstrate that the tegument protein UL21 (unique long region 21) in pseudorabies virus (PRV) dampens type I interferon signaling by triggering the degradation of CGAS (cyclic GMP-AMP synthase) through the macroautophagy/autophagy-lysosome pathway. Mechanistically, the UL21 protein scaffolds the E3 ligase UBE3C (ubiquitin protein ligase E3C) to catalyze the K27-l...
Source: Autophagy - November 7, 2022 Category: Cytology Authors: Zicheng Ma Juan Bai Chenlong Jiang Huixin Zhu Depeng Liu Mengjiao Pan Xianwei Wang Jiang Pi Ping Jiang Xing Liu Source Type: research
RTN4/Nogo-A-S1PR2 negatively regulates angiogenesis and secondary neural repair through enhancing vascular autophagy in the thalamus after cerebral cortical infarction
This study aimed to investigate the role of RTN4/Nogo-A in mediating macroautophagy/autophagy and angiogenesis in the thalamus following middle cerebral artery occlusion (MCAO). We assessed secondary neuronal damage, angiogenesis, vascular autophagy, RTN4 and S1PR2 signaling in the thalamus. The effects of RTN4-S1PR2 on vascular autophagy and angiogenesis were evaluated using lentiviral and pharmacological approaches. The results showed that RTN4 and S1PR2 signaling molecules were upregulated in parallel with angiogenesis in the ipsilateral thalamus after MCAO. Knockdown of Rtn4 by siRNA markedly reduced MAP1LC3B-II conver...
Source: Autophagy - March 9, 2022 Category: Cytology Authors: Peiyi Xiao Jinmin Gu Wei Xu Xingyang Niu Jian Zhang Jingjing Li Yicong Chen Zhong Pei Jinsheng Zeng Shihui Xing Source Type: research
The FACT complex facilitates expression of lysosomal and antioxidant genes through binding to TFEB and TFE3
Autophagy. 2022 Mar 1:1-17. doi: 10.1080/15548627.2022.2029671. Online ahead of print.ABSTRACTTFEB (transcription factor EB) and TFE3 (transcription factor binding to IGHM enhancer 3) orchestrate the cellular response to a variety of stressors, including nutrient deprivation, oxidative stress and pathogens. Here we describe a novel interaction of TFEB and TFE3 with the FAcilitates Chromatin Transcription (FACT) complex, a heterodimeric histone chaperone consisting of SSRP1 and SUPT16H that mediates nucleosome disassembly and assembly, thus facilitating transcription. Extracellular stimuli, such as nutrient deprivation or o...
Source: Autophagy - March 1, 2022 Category: Cytology Authors: Eutteum Jeong Jos é A Martina Pablo S Contreras Juhyung Lee Rosa Puertollano Source Type: research
ULK3-dependent activation of GLI1 promotes DNMT3A expression upon autophagy induction
Autophagy. 2022 Feb 28:1-12. doi: 10.1080/15548627.2022.2039993. Online ahead of print.ABSTRACTMacroautophagy/autophagy is a tightly regulated catabolic process, which contributes at baseline level to cellular homeostasis, and upon its stimulation to the adaptive cellular response to intra- and extracellular stress stimuli. Decrease of autophagy activity is occurring upon aging and thought to contribute to age-related-diseases. Recently, we uncovered, upon autophagy induction, the role of de novo DNMT3A (DNA methyltransferase 3 alpha)-mediated DNA methylation on expression of the MAP1LC3 (microtubule associated protein 1 l...
Source: Autophagy - February 28, 2022 Category: Cytology Authors: Patricia Gonz ález-Rodríguez Mathilde Cheray Lily Keane Pinelopi Engskog-Vlachos Bertrand Joseph Source Type: research
OTUD7B deubiquitinates SQSTM1/p62 and promotes IRF3 degradation to regulate antiviral immunity
Autophagy. 2022 Jan 31:1-15. doi: 10.1080/15548627.2022.2026098. Online ahead of print.ABSTRACTDeubiquitination plays an important role in the regulation of the crosstalk between macroautophagy/autophagy and innate immune signaling, yet its regulatory mechanisms are not fully understood. Here we identify the deubiquitinase OTUD7B as a negative regulator of antiviral immunity by targeting IRF3 (interferon regulatory factor 3) for selective autophagic degradation. Mechanistically, OTUD7B interacts with IRF3, and activates IRF3-associated cargo receptor SQSTM1/p62 (sequestosome 1) by removing its K63-linked poly-ubiquitin cha...
Source: Autophagy - January 31, 2022 Category: Cytology Authors: Weihong Xie Shuo Tian Jiahui Yang Sihui Cai Shouheng Jin Tao Zhou Yaoxing Wu Zhiyun Chen Yanqin Ji Jun Cui Source Type: research
Autophagy regulates differentiation of ovarian granulosa cells through degradation of WT1
Autophagy. 2022 Jan 13:1-15. doi: 10.1080/15548627.2021.2005415. Online ahead of print.ABSTRACTOvarian granulosa cells (GCs) proliferate and differentiate along with follicular growth, and this is indispensable for oocyte development and female fertility. Although the role of macroautophagy/autophagy in ovarian function has been reported, its contribution to the regulation of GC characteristics remains elusive. The siRNA-mediated knockdown of two key autophagy-related genes ATG5 and BECN1 and the autophagy inhibitor chloroquine were used to interfere with autophagy in GCs. Inhibition of autophagy both genetically and pharm...
Source: Autophagy - January 13, 2022 Category: Cytology Authors: Tong Shao Hanni Ke Ran Liu Lan Xu Shuang Han Xiruo Zhang Yujie Dang Xue Jiao Wei Li Zi-Jiang Chen Yingying Qin Shidou Zhao Source Type: research
GAK and PRKCD kinases regulate basal mitophagy
Autophagy. 2022 Jan 9:1-3. doi: 10.1080/15548627.2021.2015154. Online ahead of print.ABSTRACTThe removal of mitochondria in a programmed or stress-induced manner is essential for maintaining cellular homeostasis. To date, much research has focused upon stress-induced mitophagy that is largely regulated by the E3 ligase PRKN, with limited insight into the mechanisms regulating basal "housekeeping" mitophagy levels in different model organisms. Using iron chelation as an inducer of PRKN-independent mitophagy, we recently screened an siRNA library of lipid-binding proteins and determined that two kinases, GAK and PRKCD, act a...
Source: Autophagy - January 10, 2022 Category: Cytology Authors: Michael J Munson Benan J Mathai Matthew Yoke Wui Ng Laura Trachsel-Moncho Laura R de la Ballina Anne Simonsen Source Type: research
2AB protein of Senecavirus A antagonizes selective autophagy and type I interferon production by degrading LC3 and MARCHF8
This study showed that SVA infection induced the autophagy process in the early stage of SVA infection, and the rapamycin-induced autophagy inhibited SVA replication by degrading virus 3 C protein. To counteract this, SVA utilized 2AB protein inhibiting the autophagy process from promoting viral replication in the late stage of SVA infection. Further study showed that SVA 2AB protein interacted with MARCHF8/MARCH8 and LC3 to degrade the latter and inhibit the autophagy process. In addition, we found that MARCHF8 was a positive regulator of type I IFN (IFN-I) signaling. During the autophagy process, the SVA 2AB protein targ...
Source: Autophagy - December 29, 2021 Category: Cytology Authors: Dage Sun Ning Kong Sujie Dong Xiaoyong Chen Wenzhen Qin Hua Wang Yajuan Jiao Huanjie Zhai Liwei Li Fei Gao Lingxue Yu Hao Zheng Wu Tong Hai Yu Wen Zhang Guangzhi Tong Tongling Shan Source Type: research
