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MicroRNA-93-5p expression in tumor tissue and its tumor suppressor function via targeting programmed death ligand-1 in colorectal cancer.
This article is protected by copyright. All rights reserved. PMID: 32068322 [PubMed - as supplied by publisher]
Source: Cell Biology International - February 17, 2020 Category: Cytology Authors: Chen YL, Wang GX, Lin BA, Huang JS Tags: Cell Biol Int Source Type: research

RNA interference targeting CD147 inhibits the invasion of human cervical squamous carcinoma cells by downregulating MMP-9.
Abstract Cervical squamous carcinoma is a highly invasive tumour that has a great capacity to metastasise. Extracellular matrix metalloproteinase inducer (EMMPRIN or CD147), a member of the immunoglobulin superfamily, is a widely distributed cell surface glycoprotein. It is highly expressed on malignant tumour cell surfaces, including human cervical squamous carcinoma. It also plays a critical role in the invasive and metastatic activity of malignant cells by stimulating the expression of matrix metalloproteinases (MMPs). The anti-invasive effect of small interfering RNA (siRNA) against CD147 on human cervical squ...
Source: Cell Biology International - March 28, 2013 Category: Cytology Authors: Fan X, Wu W, Shi H, Han J Tags: Cell Biol Int Source Type: research

Calpains are required for invasive and metastatic potentials of human HCC cells.
Abstract Calpains are a conserved family of calcium-dependent cysteine proteinases involved in various cellular functions. Two ubiquitous isoforms, µ- and m-calpain, are key members of the calpain family that play essential roles in regulating cell migration and invasion. However, it remains unclear whether they are involved in the progression of hepatocellular carcinoma (HCC). Here, we investigated the functions of µ- and m-calpain in the invasive and metastatic processes of human hepatoma cells. Our results indicated that the expression levels of calpains were elevated in HCC cells compared with those in norma...
Source: Cell Biology International - June 7, 2013 Category: Cytology Authors: Chen B, Tang J, Guo YS, Li Y, Chen ZN, Jiang JL Tags: Cell Biol Int Source Type: research

Inhibition of mTOR signaling potentiates the effects of trichostatin A in human gastric cancer cell lines by promoting histone acetylation.
Abstract Deregulation of the mammalian target of rapamycin pathway (mTOR pathway) is associated with human cancer. The relationship between mTOR pathway and histone acetylation is still unclear in gastric cancer. Immunohistochemistry was used to examine the phosphorylation of mTOR and eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) in gastric cancer (GC) tissues. MKN45 and SGC7901 cells were treated with the mTOR inhibitor rapamycin (RAPA) alone or in combination with the phosphatidylinositol 3-kinase inhibitor LY294002 and the histone deacetylase (HDAC) inhibitor trichostatin A (TSA). Small...
Source: Cell Biology International - September 13, 2013 Category: Cytology Authors: Sun DF, Zhang YJ, Tian XQ, Chen YX, Fang JY Tags: Cell Biol Int Source Type: research

Fibronectin promotes migration and invasion of ovarian cancer cells through up-regulation of FAK-PI3K/Akt pathway.
This study investigates the mechanism of fibronectin (Fn) in stimulating ovarian cancer cell migration and invasion through up-regulation of FAK pathway. Human ovarian cancer cells (OVCAR-3, A2780/CP70) were cultured and treated with fibronectin (10 µg/ml). Trans-well plates were used to conduct the migration assay, real-time RT-PCR for FAK mRNA expression, and FAK siRNA for blocking FAK expression. Western blots were used for P-FAK, P-PI3K and P-Akt analysis. Fibronectin treated OVCAR-3, A2780/CP70 cells have increased ability to migrate and invade. It significantly promoted this behaviour through the phosphorylation o...
Source: Cell Biology International - September 21, 2013 Category: Cytology Authors: Yousif NG Tags: Cell Biol Int Source Type: research

Bcl-2 down-regulation by small interfering RNA induces Beclin1-dependent autophagy in human SGC-7901 cells.
Abstract While Bcl-2 protein is involved in the regulation of apoptosis, recent research showed that Beclin1, described as the essential autophagy effector and haploinsufficent tumour suppressor, was originally isolated as a Bcl-2 interacting protein. Beclin1 interacts with Bcl-2 through a BH3 domain; nevertheless, the function of the anti-apoptotic gene, Bcl-2, in autophagy is not well understood. We explored the role of Bcl-2 in autophagy in human SGC-7901 cells in which Bcl-2 is overexpressed. Knockdown of Bcl-2 by small interfering RNA in human SGC-7901 cells downregulated Bcl-2 protein levels ∼82% and induc...
Source: Cell Biology International - July 7, 2014 Category: Cytology Authors: Du Y, Ji X Tags: Cell Biol Int Source Type: research

FAM107B is regulated by S100A4 and mediates the effect of S100A4 on the proliferation and migration of MGC803 gastric cancer cells.
In conclusion, we first provide experimental evidence suggesting that FAM107B was downregulated by S100A4 in gastric cancer MGC803 cells. And FAM107B at least partially mediates the biological effects of S100A4 in the cells. PMID: 28675500 [PubMed - as supplied by publisher]
Source: Cell Biology International - July 4, 2017 Category: Cytology Authors: Guo J, Bian Y, Wang Y, Chen L, Yu A, Sun X Tags: Cell Biol Int Source Type: research

Forkhead box C2 promotes the invasion ability of human trophoblast cells through Hedgehog (Hh) signaling pathway.
Abstract Embryonic development depends on the normal invasion of trophoblast cells. Forkhead box C2 (FOXC2) is a member of Forkhead box family, which is involved in the tumor cells invasion. The aim of this study was to explore the roles of FOXC2 on the invasion of human trophoblast cells, and further study its molecular mechanism. The mRNA and protein levels of FOXC2 in human normal trophoblast and choriocarcinoma cell lines were analyzed by quantitative real-time PCR (qRT-PCR) and western blot assays, respectively. Methylthiazolyldiphenyl-tetrazo lium bromide (MTT) and transwell assays were separately performed ...
Source: Cell Biology International - February 21, 2018 Category: Cytology Authors: Zhang Y, Zhang Y Tags: Cell Biol Int Source Type: research

MicroRNA-150 restores endothelial cell function and attenuates vascular remodeling by targeting PTX3 through the NF- κB signaling pathway in mice with acute coronary syndrome.
MicroRNA-150 restores endothelial cell function and attenuates vascular remodeling by targeting PTX3 through the NF-κB signaling pathway in mice with acute coronary syndrome. Cell Biol Int. 2018 May 09;: Authors: Luo XY, Zhu XQ, Li Y, Wang XB, Yin W, Ge YS, Ji WM Abstract MicroRNAs have been known to function as important regulators in the vascular system, with various physiopathological effects such as vascular remodeling and hypertension modulation. We aimed to explore whether microRNA-150 (miR-150) regulates endothelial cell function and vascular remodeling in acute coronary syndrome (ACS), and th...
Source: Cell Biology International - May 9, 2018 Category: Cytology Authors: Luo XY, Zhu XQ, Li Y, Wang XB, Yin W, Ge YS, Ji WM Tags: Cell Biol Int Source Type: research

Implication of SLIT3-ROBO1/ROBO2 in granulosa cell proliferation, differentiation and follicle selection in the prehierarchical follicles of hen ovary.
Abstract The SLIT/ROBO pathway has been implicated in prehierarchical follicular development of hen ovary by an intrafollicular autocrine and/or paracrine fashion. SLIT3, one of the key components of the SLIT/ROBO family, serves as a ligand that potentially interacts with the four receptors, ROBO1, ROBO2, ROBO3 and ROBO4. But the exact roles and regulatory mechanism of SLIT3 in chicken ovarian follicle development remain largely unclear. The present study was conducted to investigate the potential roles and molecular regulation of SLIT3 in granulosa cell (GC) proliferation, differentiation and follicle selection w...
Source: Cell Biology International - October 4, 2018 Category: Cytology Authors: Xu R, Qin N, Xu X, Sun X, Chen X, Zhao J Tags: Cell Biol Int Source Type: research

OGR1 mediates the inhibitory effects of acidic environment on proliferation and angiogenesis of endothelial progenitor cells.
This study attempted to whether OGR1 mediates the effects of acid on proliferation, migration, and angiogenesis in EPCs. FITC-UEA-I and Dil-Ac-LDL double-staining methods were used to identify EPCs. Expression of OGR1 was analyzed by RT-PCR and western blot after incubation in media ranging in pH, cell counting kit-8 and cell cycle analysis were used to analyze proliferation and cell cycle distribution. Scratch test, transwell migration assay, and tube formation experiments were performed to analyze migration and vascularization of EPCs after silencing OGR1 with siRNA. The result show EPCs were positive for FITC-UEA-I and ...
Source: Cell Biology International - May 21, 2019 Category: Cytology Authors: Ding S, Xu J, Zhang Q, Chen F, Zhang J, Gui K, Xiong M, Li B, Ruan Z, Zhao M Tags: Cell Biol Int Source Type: research

Extracellular vesicle-derived circ_SLC19A1 promotes prostate cancer cell growth and invasion through the miR-497/septin 2 pathway.
This article is protected by copyright. All rights reserved. PMID: 31903637 [PubMed - as supplied by publisher]
Source: Cell Biology International - January 4, 2020 Category: Cytology Authors: Zheng Y, Li JX, Chen CJ, Lin ZY, Liu JX, Lin FJ Tags: Cell Biol Int Source Type: research

Long noncoding RNA ERICD interacts with ARID3A via E2F1 and regulates migration and proliferation of osteosarcoma cells.
Abstract Long noncoding RNA (lncRNA) dysregulation is known to be taking part in majority of cancers, including osteosarcoma. In one of our previous studies, we showed that lncRNA MEG3 is being regulated by microRNA-664a (miR-664a) suppresses the migratory potential of osteosarcoma cells (U-2OS). We now report a novel lncRNA, namely, ERICD, which is linked to the transcription factor AT-rich interaction domain 3A (ARID3A) in U-2OS cells. We show that ARID3A binds to ERICD and indirectly interacts with each other via the E2F transcription factor 1 (E2F1). Furthermore, small interfering RNA (siRNA)-mediated knockdow...
Source: Cell Biology International - August 3, 2020 Category: Cytology Authors: Arman K, Saadat KASM, Igci YZ, Bozgeyik E, Ikeda MA, Cakmak EA, Arslan A Tags: Cell Biol Int Source Type: research

Calycosin suppresses colorectal cancer progression by targeting ER β, upregulating PTEN, and inhibiting PI3K/Akt signal pathway
In this study, we analyzed the effect of calycosin on the viability and apoptosis of human CRC HCT116 and SW480 cells via MTT assay, flow cytometry assay, and caspase-3/7 activity assay. The protein expressions of estrogen receptor β (ERβ), PTEN, and PI3K/Akt signal pathways were determined by Western blot analysis. And then, the alterations of biological behavior in CRC cells transfected with ERβ siRNA were analyzed. Mouse xenograft models were further performed to detect the antitumor effect in vivo. The results show that calycosin reduces CRC cell viability, induces cell apoptosis, and suppresses xenograft tumor grow...
Source: Cell Biology International - July 17, 2022 Category: Cytology Authors: Lin Zhu Sha Liu Yi-Fan Liao Yan-Mei Sheng Ji-Chun He Zheng-Xue Cai Qiong Man Yi-Ying Wu Source Type: research

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