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Source: Cell Biology International

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Total 159 results found since Jan 2013.

miR-4443 targets TRIM14 to suppress metastasis and energy metabolism of papillary thyroid carcinoma (PTC) in vitro
This study was designed to investigate the relationship between miR-4443 and TRIM14 on metastasis and energy metabolism in PTC and the underlying mechanisms. To this end, human PTC cells (SW1736 and MZ-CRC-1) were transfected with a miR-4443 mimic or miR-4443 inhibitor + siRNA-TRIM14, and then dual luciferase assay, Transwell, Seahorse, and Western blot were performed to assess the function of miR-4443 and the underlying mechanism. We found that ectopic expression of miR-4443 inhibited PTC cell migration, invasion, ATP production, and aerobic glycolysis, while inhibition of miR-4443 had the opposite effect. miR-4443 direct...
Source: Cell Biology International - May 29, 2021 Category: Cytology Authors: Xiao-Ming Zuo Hai-Wen Sun Hong Fang Yun Wu Qun Shi Yi-Fan Yu Source Type: research

Effects of indoleamine 2, 3-dioxygenase (IDO) silencing on immunomodulatory function and cancer promoting characteristic of adipose derived mesenchymal stem cells (ASCs)
This article is protected by copyright. All rights reserved.PMID:34498786 | DOI:10.1002/cbin.11698
Source: Cell Biology International - September 9, 2021 Category: Cytology Authors: Fahimeh Heidari Mahboobeh Razmkhah Vahid Razban Nasrollah Erfani Source Type: research

Knockdown of YKL-40 inhibits angiogenesis through regulation of VEGF/VEGFR2 and ERK1/2 signaling in endometrial cancer
This article is protected by copyright. All rights reserved.PMID:34498339 | DOI:10.1002/cbin.11699
Source: Cell Biology International - September 9, 2021 Category: Cytology Authors: Hong-Yan Chen Zhao-Yu Zhou Yan-Lu Luo Qin Luo Jiang-Tao Fan Source Type: research

Hexavalent chromium induces centrosome amplification through ROS-ATF6-PLK4 pathway in colon cancer cells
In conclusion, our results suggest that hexavalent chromium induces CA via the ROS-ATF6-PLK4 pathway and provides molecular targets for inhibiting chromium-mediated CA, which may be useful for the assessment of CA in chromium-promoted tumorigenesis and cancer cell metastasis. This article is protected by copyright. All rights reserved.PMID:35293662 | DOI:10.1002/cbin.11791
Source: Cell Biology International - March 16, 2022 Category: Cytology Authors: Xue Kai Bian Jia Li Guo Si Xian Xu Ya Wen Han Shao Chin Lee Ji Zhong Zhao Source Type: research

ANKHD1 contributes to the malignant phenotype of triple-negative breast cancer cells
Cell Biol Int. 2022 Jul 16. doi: 10.1002/cbin.11844. Online ahead of print.ABSTRACTAnkyrin repeat and KH domain-containing protein 1, ANKHD1, has been identified as a regulator of signaling pathways and cellular processes of relevance in carcinogenesis. However, the role of ANKHD1 in breast cancer remains unclear. The aim of the present study was to characterize the expression pattern and involvement of ANKHD1 in the malignant phenotype of breast cancer cell lines and to investigate the clinical relevance of ANKHD1 in a breast cancer context. Gene and protein expressions were assessed in the cell lines by quantitative reve...
Source: Cell Biology International - July 17, 2022 Category: Cytology Authors: Bruna O de Almeida Larissa C de Almeida Leticia V Costa-Lotufo Jo ão A Machado-Neto Source Type: research

Significance of Oct-4 transcription factor as a pivotal therapeutic target for CD44 < sup > + < /sup > /24 < sup > - < /sup > mammary tumor initiating cells: Aiming at the root of the recurrence
In this study, we have attempted to identify previously unrecognized CSC survival factors that can be used as druggable targets for bCSCs apoptosis regulators isolated from the TNBC line, MDA MB 468. After a thorough literature review, Oct-4 was identified as the most promising marker for its unique abundance in cancer and absence in normal cells and the contribution of Oct-4 to the sustenance of cancer cells. We then validated a very high expression of Oct-4 in the MDA MB 468 bCSCs population using flow-cytometry. The loss of Oct-4 was carried out using small interfering RNA (siRNA)-mediated knockdown in the bCSCs, follow...
Source: Cell Biology International - December 27, 2022 Category: Cytology Authors: Utsav Sen Shanooja Shanavas Apoorva H Nagendra Muhammad Nihad Debajit Chaudhury Hari K Rachamalla Rajkumar Banerjee Sudheer Shenoy P Bipasha Bose Source Type: research

The role of tribbles homolog 2 in vascular smooth muscle cell proliferation
Cell Biol Int. 2023 Jan 10. doi: 10.1002/cbin.11982. Online ahead of print.ABSTRACTTribbles homolog 2 (TRIB2) functions as an adapter protein that regulates signal transductions involved in a variety of cellular functions, including tumorigenesis. However, the role of TRIB2 in the proliferation of vascular smooth muscle cells (VSMCs) and the underlying expression mechanisms remain unclear. The present study investigated the role of TRIB2 in VSMC proliferation and revealed that TRIB2 expression increases following vascular injury and platelet-derived growth factor (PDGF)-BB-stimulated VSMCs. We found that pretreatment with ...
Source: Cell Biology International - January 10, 2023 Category: Cytology Authors: Akira Takaguri Rena Ishizaka Shota Maki Kumi Satoh Source Type: research

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