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Source: Cellular Physiology and Biochemistry

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Total 223 results found since Jan 2013.

Effects of MicroRNA-499 On the Inflammatory Damage of Endothelial Cells During Coronary Artery Disease Via the Targeting of PDCD4 Through the NF- Κβ/TNF-α Signaling Pathway
Conclusion: Down-regulated miR-499 expression increased PDCD4 expression and protected endothelial cells from inflammatory damage during CAD by inhibiting the NF- κB/TNF-α signaling pathway.Cell Physiol Biochem 2017;44:110 –124
Source: Cellular Physiology and Biochemistry - November 3, 2017 Category: Cytology Source Type: research

The Intracranial Aneurysm Gene THSD1 Connects Endosome Dynamics to Nascent Focal Adhesion Assembly
Conclusions: The data suggest that THSD1 functions at the interface between endosome dynamics and nascent focal adhesion assembly that is impaired by THSD1 rare variants identified from intracranial aneurysm patients.Cell Physiol Biochem 2017;43:2200 –2211
Source: Cellular Physiology and Biochemistry - October 25, 2017 Category: Cytology Source Type: research

The Impact of Cysteine-Rich Intestinal Protein 1 (CRIP1) on Thyroid Carcinoma
Conclusion: In conclusion, CRIP1 acts as an oncogene in the cell proliferation, migration, and invasion processes of thyroid carcinoma. CRIP1 may serve well as an independent prognostic marker with significant predictive power for use in thyroid carcinoma therapy.Cell Physiol Biochem 2017;43:2037 –2046
Source: Cellular Physiology and Biochemistry - October 25, 2017 Category: Cytology Source Type: research

Suppression of Sirtuin-1 Increases IL-6 Expression by Activation of the Akt Pathway During Allergic Asthma
Conclusion: Our results indicate the potential role of SIRT1 in regulating inflammation by modulation of IL-6 expression in an Akt-dependent manner during allergic asthma.Cell Physiol Biochem 2017;43:1950 –1960
Source: Cellular Physiology and Biochemistry - October 20, 2017 Category: Cytology Source Type: research

Calcium-Sensing Receptor Stimulation in Cultured Glomerular Podocytes Induces TRPC6-Dependent Calcium Entry and RhoA Activation
Conclusion: TRPC6 is involved in the regulation of stress fiber formation and focal adhesions via the RhoA pathway in response to CaSR activation. This may explain the direct protective action of CaSR agonists.Cell Physiol Biochem 2017;43:1777 –1789
Source: Cellular Physiology and Biochemistry - October 19, 2017 Category: Cytology Source Type: research

Isoflavones Induce BEX2-Dependent Autophagy to Prevent ATR-Induced Neurotoxicity in SH-SY5Y Cells
Conclusion: Isoflavones activate BEX2-dependent autophagy, protecting against ATR-induced neuronal apoptosis.Cell Physiol Biochem 2017;43:1866 –1879
Source: Cellular Physiology and Biochemistry - October 19, 2017 Category: Cytology Source Type: research

Leonurine Prevents Atherosclerosis Via Promoting the Expression of ABCA1 and ABCG1 in a Ppar γ/Lxrα Signaling Pathway-Dependent Manner
Conclusions: Leonurine can promote cholesterol efflux and alleviate cellular lipid accumulation by magnifying the expression of ABCA1/G1 in a PPAR γ/LXRα signaling pathway-dependent manner in human THP-1 macrophage-derived foam cells and abate atherogenesis in apoE-/- mice, which may offer a promising therapeutic intervention of leonurine in protecting against AS.Cell Physiol Biochem 2017;43:1703 –1717
Source: Cellular Physiology and Biochemistry - October 18, 2017 Category: Cytology Source Type: research

Exogenous H2S Protects Against Diabetic Cardiomyopathy by Activating Autophagy via the AMPK/mTOR Pathway
Conclusions: Our findings demonstrated that H2S decreases oxidative stress and protects against mitochondria injury, activates autophagy, and eventually leads to cardiac protection via the AMPK/mTOR pathway.Cell Physiol Biochem 2017;43:1168 –1187
Source: Cellular Physiology and Biochemistry - October 4, 2017 Category: Cytology Source Type: research

Long Noncoding RNA FAL1 Promotes Cell Proliferation, Invasion and Epithelial-Mesenchymal Transition Through the PTEN/AKT Signaling Axis in Non-Small Cell Lung Cancer
Conclusion: FAL1 may promote tumorigenesis and progression of NSCLC through the PTEN/AKT axis, which could lead to lncRNA-related diagnostics and therapeutics in NSCLC.Cell Physiol Biochem 2017;43:339 –352
Source: Cellular Physiology and Biochemistry - August 30, 2017 Category: Cytology Source Type: research

Effects of the Long Non-Coding RNA HOST2 On the Proliferation, Migration, Invasion and Apoptosis of Human Osteosarcoma Cells
Conclusions: Inhibition of lnc-HOST2 could suppress the proliferation, migration, and invasion and promote the apoptosis of osteosarcoma cells.Cell Physiol Biochem 2017;43:320 –330
Source: Cellular Physiology and Biochemistry - August 30, 2017 Category: Cytology Source Type: research

Tetrahydroxystilbene Glycoside Improves Microvascular Endothelial Dysfunction and Ameliorates Obesity-Associated Hypertension in Obese ZDF Rats Via Inhibition of Endothelial Autophagy
Conclusion: Endothelial dysfunction in ZDF rats is partially attributable to excessive autophagy. TSG improves endothelial function and exerts hypotensive effectsvia regulation of endothelial autophagy.Cell Physiol Biochem 2017;43:293 –307
Source: Cellular Physiology and Biochemistry - August 30, 2017 Category: Cytology Source Type: research

MicroRNA-222 Promotes the Proliferation of Pulmonary Arterial Smooth Muscle Cells by Targeting P27 and TIMP3
Conclusion: miR-222 promotes PASMC proliferation at least partially through targeting P27 and TIMP3.Cell Physiol Biochem 2017;43:282 –292
Source: Cellular Physiology and Biochemistry - August 30, 2017 Category: Cytology Source Type: research

mPGES-1-Derived PGE < sub > 2 < /sub > Contributes to Indoxyl Sulfate-Induced Mesangial Cell Proliferation
Conclusion: mPGES-1-derived PGE2 contributed to IS-induced mesangial cell proliferation.Cell Physiol Biochem 2017;43:271 –281
Source: Cellular Physiology and Biochemistry - August 30, 2017 Category: Cytology Source Type: research

Extracellular HSP70 Activates ERK1/2, NF-kB and Pro-Inflammatory Gene Transcription Through Binding with RAGE in A549 Human Lung Cancer Cells
Conclusions: Our results evidence eHSP70 as a novel RAGE agonist capable of influence the cross-talk between cancer and immune system cells.Cell Physiol Biochem 2017;42:2507 –2522
Source: Cellular Physiology and Biochemistry - August 22, 2017 Category: Cytology Source Type: research