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Source: Cellular Physiology and Biochemistry

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Total 223 results found since Jan 2013.

High Glucose-Induced Podocyte Injury Involves Activation of Mammalian Target of Rapamycin (mTOR)-Induced Endoplasmic Reticulum (ER) Stress
Conclusion: Our data demonstrate that the activated mTOR by Erk1/2 results in energy consumption, which in turn leads to ER stress signaling and thus induces apoptosis in HG-treated podocytes.Cell Physiol Biochem 2018;45:2431 –2443
Source: Cellular Physiology and Biochemistry - March 20, 2018 Category: Cytology Source Type: research

E74-Like Factor (ELF3) and Leptin, a Novel Loop Between Obesity and Inflammation Perpetuating a Pro-Catabolic State in Cartilage
Conclusion: Here we show, for the first time, the regulation of ELF3 expression by leptin, suggesting that this transcription factor likely mediates the inflammatory responses triggered by leptin in articular chondrocytes.Cell Physiol Biochem 2018;45:2401 –2410
Source: Cellular Physiology and Biochemistry - March 16, 2018 Category: Cytology Source Type: research

Uric Acid Induces Cardiomyocyte Apoptosis via Activation of Calpain-1 and Endoplasmic Reticulum Stress
Conclusions: These findings suggest that UA induces cardiomyocyte apoptosis through activation of calpain-1 and ER stress. These results may provide new insights into the mechanisms of hyperuricemia-associated cardiovascular risks and hopefully identify new treatment targets.Cell Physiol Biochem 2018;45:2122 –2135
Source: Cellular Physiology and Biochemistry - March 13, 2018 Category: Cytology Source Type: research

BMPER Enhances Bone Formation by Promoting the Osteogenesis-Angiogenesis Coupling Process in Mesenchymal Stem Cells
Conclusion:BMPER functions as a positive regulator of the osteogenesis-angiogenesis coupling process in hBMSCs, suggesting a novel therapeutic role ofBMPER in the regenerative capacity of bone repair.Cell Physiol Biochem 2018;45:1927 –1939
Source: Cellular Physiology and Biochemistry - March 8, 2018 Category: Cytology Source Type: research

ADAM17-Mediated Ectodomain Shedding of Toll-Like Receptor 4 as a Negative Feedback Regulation in Lipopolysaccharide-Activated Aortic Endothelial Cells
Conclusion: HAECs respond to LPS by rapid shedding of the ectodomain of TLR4 and thereby reduce the responsiveness to subsequent LPS exposure. ADAM17, downstream of p38 MAPK, is implicated in the ectodomain cleavage of TLR4.Cell Physiol Biochem 2018;45:1851 –1862
Source: Cellular Physiology and Biochemistry - March 6, 2018 Category: Cytology Source Type: research

Oxymatrine Inhibits Homocysteine-Mediated Autophagy via MIF/mTOR Signaling in Human Umbilical Vein Endothelial Cells
Conclusions: These results suggest that Hcy can evokeautophagy-activated HUVEC apoptosis/death via a MIF/mTOR signaling pathway, which can be reversed by OMT. Our results provide a new insight into a functional role of OMT in the prevention of Hcy-induced HUVEC injury and death.Cell Physiol Biochem 2018;45:1893 –1903
Source: Cellular Physiology and Biochemistry - March 6, 2018 Category: Cytology Source Type: research

Mdia1 is Crucial for Advanced Glycation End Product-Induced Endothelial Hyperpermeability
Conclusion: Our study revealed that mDia1 plays a critical role in AGE-induced microvascular hyperpermeability through binding to RAGE.Cell Physiol Biochem 2018;45:1717 –1730
Source: Cellular Physiology and Biochemistry - February 28, 2018 Category: Cytology Source Type: research

Abnormal Downregulation of Caveolin-3 Mediates the Pro-Fibrotic Action of MicroRNA-22 in a Model of Myocardial Infarction
Conclusions: Our findings demonstrate that miR-22 accelerates cardiac fibrosis through the miR-22-Cav3-PKC ε pathway, which, therefore, may represent a new therapeutic target for treatment of excessive fibrosis-associated cardiac diseases.Cell Physiol Biochem 2018;45:1641 –1653
Source: Cellular Physiology and Biochemistry - February 27, 2018 Category: Cytology Source Type: research

FOXO1, a Potential Therapeutic Target, Regulates Autophagic Flux, Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis in Human Cholangiocarcinoma QBC939 Cells
Conclusions: Taken together, our study for the first time identified FOXO1 as a potential therapeutic target to cure against human cholangiocarcinoma via regulation of autophagy, oxidative stress and MtD.Cell Physiol Biochem 2018;45:1506 –1514
Source: Cellular Physiology and Biochemistry - February 21, 2018 Category: Cytology Source Type: research

P38/TRHr-Dependent Regulation of TPO in Thyroid Cells Contributes to the Hypothyroidism of Triclosan-Treated Rats
Conclusion: Taken together, p38/TRHr-dependent regulation of TPO in thyroid cells contributes to the hypothyroidism of triclosan-treated rats.Cell Physiol Biochem 2018;45:1303 –1315
Source: Cellular Physiology and Biochemistry - February 20, 2018 Category: Cytology Source Type: research

MicroRNA-27a Suppresses Detrusor Fibrosis in Streptozotocin-Induced Diabetic Rats by Targeting PRKAA2 Through the TGF- β1/Smad3 Signaling Pathway
Conclusion: These results indicate that miR-27a may contribute to detrusor fibrosis in STZ-induced diabetic rats by targeting PRKAA2 via the TGF- β1/Smad3 signaling pathway.Cell Physiol Biochem 2018;45:1333 –1349
Source: Cellular Physiology and Biochemistry - February 20, 2018 Category: Cytology Source Type: research

Overexpression of Lymphocyte Antigen 6 Complex, Locus E in Gastric Cancer Promotes Cancer Cell Growth and Metastasis
Conclusion: LY6E over-expression in GC is potentially required for cancer cell survival, proliferation and migration.Cell Physiol Biochem 2018;45:1219 –1229
Source: Cellular Physiology and Biochemistry - February 15, 2018 Category: Cytology Source Type: research

The LncRNA EPEL Promotes Lung Cancer Cell Proliferation Through E2F Target Activation
Conclusions: Considering its specific effects on cell cycle-related E2F target genes and its significant association with the prognosis of lung cancer patients, we suggest that the transcriptional regulation of EPEL through E2F target genes is potentially a target for the development of novel therapeutic strategies for lung cancer patients.Cell Physiol Biochem 2018;45:1270 –1283
Source: Cellular Physiology and Biochemistry - February 15, 2018 Category: Cytology Source Type: research

Expression of MicroRNA-448 and SIRT1 and Prognosis of Obese Type 2 Diabetic Mellitus Patients After Laparoscopic Bariatric Surgery
Conclusion: The results demonstrated that miR-448 and its target gene SIRT1 can serve as prognostic indicators for obese T2DM patients after laparoscopic bariatric surgery.Cell Physiol Biochem 2018;45:935 –950
Source: Cellular Physiology and Biochemistry - February 9, 2018 Category: Cytology Source Type: research

Protective Effects of Oxymatrine on Vascular Endothelial Cells from High-Glucose-Induced Cytotoxicity by Inhibiting the Expression of A < sub > 2B < /sub > Receptor
Conclusion: OMT may protect the HUVECs from high glucose-induced cytotoxicity through inhibitting the expression of A2B receptor and inflammatory factors as well as decreasing the phosphorylation of p38 and ERK1/2.Cell Physiol Biochem 2018;45:558 –571
Source: Cellular Physiology and Biochemistry - January 31, 2018 Category: Cytology Source Type: research