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Source: Cellular Physiology and Biochemistry
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Total 223 results found since Jan 2013.
High Expressions of CUL4A and TP53 in Colorectal Cancer Predict Poor Survival
Conclusion: CUL4A expression correlated positively with the prognosis of colorectal cancer. Mechanistically, ZEB1 was confirmed to mediate the function of CUL4A in regulating the EMT. The assessment of both CUL4A and mutant TP53 expression will be helpful in predicting colon cancer prognosis.Cell Physiol Biochem 2018;51:2829 –2842
Source: Cellular Physiology and Biochemistry - December 18, 2018 Category: Cytology Source Type: research
Intermittent-Hypoxia-Induced Autophagy Activation Through the ER-Stress-Related PERK/eIF2 α/ATF4 Pathway is a Protective Response to Pancreatic β-Cell Apoptosis
Conclusion: IH induces autophagy activation through the ER-stress-related PERK/eIF2 α/ATF4 signaling pathway, which is a protective response to pancreatic β-cell apoptosis caused by IH.Cell Physiol Biochem 2018;51:2955 –2971
Source: Cellular Physiology and Biochemistry - December 18, 2018 Category: Cytology Source Type: research
Resveratrol Ameliorates Lipid Droplet Accumulation in Liver Through a SIRT1/ ATF6-Dependent Mechanism
Conclusion: Taken together, these findings indicate that RSV supplementation improves hepatic steatosis by ameliorating the accumulation of LDs, and this might be partially mediated by a SIRT1/ATF6-dependent mechanism.Cell Physiol Biochem 2018;51:2397 –2420
Source: Cellular Physiology and Biochemistry - December 13, 2018 Category: Cytology Source Type: research
High Expressions of CUL4A and TP53 in Colorectal Cancer Predict Poor Survival
Conclusion: CUL4A expression correlated positively with the prognosis of colorectal cancer. Mechanistically, ZEB1 was confirmed to mediate the function of CUL4A in regulating the EMT. The assessment of both CUL4A and mutant TP53 expression will be helpful in predicting colon cancer prognosis.Cell Physiol Biochem 2018;51:2829 –2842
Source: Cellular Physiology and Biochemistry - December 13, 2018 Category: Cytology Source Type: research
Mammalian STE20-Like Kinase 1 Deletion Alleviates Renal Ischaemia-Reperfusion Injury via Modulating Mitophagy and the AMPK-YAP Signalling Pathway
Conclusion: Overall, our results demonstrate that the pathogenesis of renal I/R injury is closely associated with an increase in Mst1 expression and the inactive AMPK-YAP-OPA1 signalling pathway. Based on this, strategies to repress Mst1 expression and activate mitophagy could serve as therapeutic targets to treat kidney ischaemia-reperfusion injury.Cell Physiol Biochem 2018;51:2359 –2376
Source: Cellular Physiology and Biochemistry - December 7, 2018 Category: Cytology Source Type: research
Simvastatin Protects Dopaminergic Neurons Against MPP < sup > + < /sup > -Induced Oxidative Stress and Regulates the Endogenous Anti-Oxidant System Through ERK
Conclusion: Our results provide strong evidence that ERK1/2-mediated modulation of the anti-oxidant system after simvastatin treatment may partially explain the anti-oxidant activity in experimental parkinsonian models. These findings contribute to a better understanding of the critical roles of simvastatin via the ERK1/2-mediated modulation of the anti-oxidant system, which may be relevant for treating PD.Cell Physiol Biochem 2018;51:1957 –1968
Source: Cellular Physiology and Biochemistry - December 4, 2018 Category: Cytology Source Type: research
B-Cell Receptor-Associated Protein 31 Regulates the Expression of Valosin-Containing Protein Through Elf2
Conclusion: These results indicate that Bap31 regulates the expression of VCP possibly via Elf2 and support the potential molecular function of Bap31 in CNS diseases.Cell Physiol Biochem 2018;51:1799 –1814
Source: Cellular Physiology and Biochemistry - November 30, 2018 Category: Cytology Source Type: research
Ectodomain Shedding of RAGE and TLR4 as a Negative Feedback Regulation in High-Mobility Group Box 1-Activated Aortic Endothelial Cells
Conclusion: In response to HMGB1 stimulation, HAECs rapidly undergo ectodomain shedding of RAGE and TLR4, and thereby become insensitive to further HMGB1 stimulation. ADAM17, activated through RAGE-p38 MAPK pathway, is implicated in the ectodomain cleavage of the receptors.Cell Physiol Biochem 2018;51:1632 –1644
Source: Cellular Physiology and Biochemistry - November 29, 2018 Category: Cytology Source Type: research
microRNA-29a-3p, Up-Regulated in Human Gastric Cells and Tissues with < b > < i > H.Pylori < /i > < /b > Infection, Promotes the Migration of GES-1 Cells via A20-Mediated EMT Pathway
Conclusion: The miR-29a-3p may act as a tumor promotive miRNA by regulating cells migration through directly targeting of A20 gene in human gastric epithelial cells infected withH.pylori.Cell Physiol Biochem 2018;51:1250 –1263
Source: Cellular Physiology and Biochemistry - November 28, 2018 Category: Cytology Source Type: research
Ginsenoside 20(S)-Rg3 Prevents PKM2-Targeting miR-324-5p from H19 Sponging to Antagonize the Warburg Effect in Ovarian Cancer Cells
Conclusion: Our study revealed that 20(S)-Rg3 blocked the competitive inhibition of H19 on miR-324-5p, which enhanced the suppression of miR-324-5p on PKM2 and therefore inhibited the Warburg effect and repressed tumorigenesis. In a word, 20(S)-Rg3 inhibited the Warburg effect in ovarian cancer cells via H19/miR-324-5p/PKM2 pathway.Cell Physiol Biochem 2018;51:1340 –1353
Source: Cellular Physiology and Biochemistry - November 27, 2018 Category: Cytology Source Type: research
Nuclear Translocation of Argonaute 2 in Cytokine-Induced Senescence
Conclusion: IFN- γ and TNF induce a stable cell cycle arrest of cancer cells that is accompanied by a fast nuclear Ago2 translocation and repression of Ago2-regulated cell cycle control genes. As Ago2 downregulation impairs cytokine-induced growth regulation, Ago2 may contribute to tissue homeostasis in human cance rs.Cell Physiol Biochem 2018;51:1103 –1118
Source: Cellular Physiology and Biochemistry - November 26, 2018 Category: Cytology Source Type: research
CDK6 and miR-320c Co-Regulate Chondrocyte Catabolism Through NF- κB Signaling Pathways
Conclusion: CDK6 and miR-320c co-regulate hBMSC chondrogenesis and IL-1 β-induced chondrocyte inflammation through the NF-kB signaling pathway, suggesting that miR-320c and CDK6 inhibitors can be used to repress catabolism in human chondrocytes.Cell Physiol Biochem 2018;51:909 –923
Source: Cellular Physiology and Biochemistry - November 22, 2018 Category: Cytology Source Type: research
MicroRNA-485 Modulates the TGF- β/ Smads Signaling Pathway in Chronic Asthmatic Mice by Targeting Smurf2
Conclusion: Overexpressed miR-485 inhibits cell proliferation and promotes apoptosis of ASMCs through the Smurf2-mediated TGF- β/Smads signaling pathway in mice with chronic asthma.Cell Physiol Biochem 2018;51:692 –710
Source: Cellular Physiology and Biochemistry - November 21, 2018 Category: Cytology Source Type: research
SphK1/S1P Mediates PDGF-Induced Pulmonary Arterial Smooth Muscle Cell Proliferation via miR-21/BMPRII/Id1 Signaling Pathway
Conclusion: Our study indicates that SphK1/S1P pathway plays an important role in PDGF-induced PASMC proliferation via miR-21/BMPRII/Id1 axis and targeting against SphK1/S1P axis might be a novel strategy in the prevention and treatment of pulmonary arterial hypertension (PAH).Cell Physiol Biochem 2018;51:487 –500
Source: Cellular Physiology and Biochemistry - November 19, 2018 Category: Cytology Source Type: research
