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Adenosine A2A Receptor Promotes Collagen Type III Synthesis Via β‐Catenin Activation in Human Dermal Fibroblasts
Conclusions and ImplicationsA2AR stimulation promotes Col3 synthesis via canonical and non‐canonical β‐catenin activation, consistent with the role of A2AR in dermal fibrosis and scarring.
Source: British Journal of Pharmacology - August 31, 2016 Category: Drugs & Pharmacology Authors: Gibran Shaikh, Jin Zhang, Miguel Perez ‐Aso, Aranzazu Mediero Munoz, Bruce Cronstein Tags: RESEARCH PAPER Source Type: research

Drp‐1, a potential therapeutic target for brain ischemic stroke
Conclusions and ImplicationsOur findings that Drp‐1 may increase the resistance of neurons of hippocampal CA3 affected by global ischemia and the tolerance conferred by IPC highlight Drp‐1 as a potential target for translocation to effective therapy for brain ischemic stroke.
Source: British Journal of Pharmacology - February 24, 2016 Category: Drugs & Pharmacology Authors: W Zuo, P F Yang, J Chen, Z Zhang, N H Chen Tags: RESEARCH PAPER Source Type: research

A novel mechanism for cytoprotection against hypoxic injury: δ‐opioid receptor‐mediated increase in Nrf2 translocation
ConclusionsDOR is cytoprotective against H/R injury and this effect is at least partially dependent on Nrf2 function.
Source: British Journal of Pharmacology - December 2, 2014 Category: Drugs & Pharmacology Authors: Shan Cao, Dongman Chao, Honghao Zhou, Gianfranco Balboni, Ying Xia Tags: Research Paper Source Type: research

JAK2/STAT5/Bcl‐xL signalling is essential for erythropoietin‐mediated protection against apoptosis induced in PC12 cells by the amyloid β−peptide Aβ25–35
Conclusions and ImplicationsEPO protected PC12 cells against Aβ25–35‐induced neurotoxicity. Activation of JAK2/STAT5/Bcl‐xL pathway was important in EPO‐mediated neuroprotection. EPO may serve as a novel protective agent against Aβ25–35‐induced cytotoxicity in, for instance, Alzheimer's disease.
Source: British Journal of Pharmacology - June 10, 2014 Category: Drugs & Pharmacology Authors: Rong Ma, Jing Hu, Chengfang Huang, Min Wang, Jizhou Xiang, Gang Li Tags: RESEARCH PAPER Source Type: research

Inhibition of fatty acid amide hydrolase activates Nrf2 signalling and induces heme oxygenase 1 transcription in breast cancer cells
Conclusions and ImplicationsThese data uncovered a novel mechanism by which inhibition of FAAH or exposure to AEA induced HO‐1 transcripts and implicating AEA and FAAH as direct modifiers in signalling mediated activation of Nrf2‐HO‐1 pathway, independent of cannabinoid receptors.
Source: British Journal of Pharmacology - September 17, 2013 Category: Drugs & Pharmacology Authors: H Li, J T Wood, K M Whitten, S K Vadivel, S Seng, A Makriyannis, H K Avraham Tags: RESEARCH PAPER Source Type: research

Inhibition Of Fatty Acid Amide Hydrolase Activates Nrf2 Signaling And Induces Heme Oxygenase 1 Transcription In Breast Cancer Cells
Conclusions and ImplicationsThese data uncovered a novel mechanism by which inhibition of FAAH or exposure to AEA induced HO‐1 transcripts and implicating AEA and FAAH as direct modifiers in signaling mediated activation of Nrf2‐HO‐1 pathway, independent of cannabinoid receptors.
Source: British Journal of Pharmacology - January 24, 2013 Category: Drugs & Pharmacology Authors: H Li, JT Wood, KM Whitten, SK Vadival, S Seng, A Makriyannis, S Avraham, HK Avraham Tags: Research Paper Source Type: research