Inhibition of fatty acid amide hydrolase activates Nrf2 signalling and induces heme oxygenase 1 transcription in breast cancer cells

Conclusions and ImplicationsThese data uncovered a novel mechanism by which inhibition of FAAH or exposure to AEA induced HO‐1 transcripts and implicating AEA and FAAH as direct modifiers in signalling mediated activation of Nrf2‐HO‐1 pathway, independent of cannabinoid receptors.

Source: British Journal of Pharmacology - September 17, 2013 Category: Drugs & Pharmacology Authors: H Li, J T Wood, K M Whitten, S K Vadivel, S Seng, A Makriyannis, H K Avraham Tags: RESEARCH PAPER Source Type: research