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Source: Molecular Cancer

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Total 57 results found since Jan 2013.

DNA-dependent protein kinase catalytic subunit (DNA-PKcs)-SIN1 association mediates ultraviolet B (UVB)-induced Akt Ser-473 phosphorylation and skin cell survival
Conclusion: Taken together, these results strongly suggest that DNA-PKcs-mTORC2 association is required for UVB-induced Akt Ser-473 phosphorylation and cell survival, and might be important for tumor cell transformation.
Source: Molecular Cancer - December 24, 2013 Category: Cancer & Oncology Authors: Ying TuBo YangChao JiZhi YangHua GuChun-Cheng LuRong WangZhong-Lan SuBin ChenWei-Ling SunJi-Ping XiaZhi-Gang BiLi He Source Type: research

Proteomic analysis reveals heat shock protein 70 has a key role in polycythemia Vera
JAK-STAT signaling through the JAK2V617F mutation is central to the pathogenesis of myeloproliferative neoplasms (MPN). However, other events could precede the JAK2 mutation. The aim of this study is to analyze the phenotypic divergence between polycytemia vera (PV) and essential thrombocytemia (ET) to find novel therapeutics targets by a proteomic and functional approach to identify alternative routes to JAK2 activation. Through 2D-DIGE and mass spectrometry of granulocyte protein from 20 MPN samples, showed differential expression of HSP70 in PV and ET besides other 60 proteins. Immunohistochemistry of 46 MPN bone marrow...
Source: Molecular Cancer - November 19, 2013 Category: Cancer & Oncology Authors: Miguel GallardoSantiago BarrioMarisol FernandezAlberto ParadelaAlicia ArenasOscar ToldosRosa AyalaEnriqueta AlbizuaAna JimenezSantiago RedondoRosa Garcia-MartinFlorinda GilsanzJuan AlbarJoaquin Martinez-Lopez Source Type: research

A novel Hsp90 inhibitor AT13387 induces senescence in EBV-positive nasopharyngeal carcinoma cells and suppresses tumor formation
Conclusion: AT13387 suppressed cell growth, cell migration, tumor sphere formation and induced cellular senescence on EBV-positive NPC cell line C666-1. Also, the antitumor effect of AT13387 was demonstrated in an in vivo model. This study provided experimental evidence for the preclinical value of using AT13387 as an effective antitumor agent in treatment of NPC.
Source: Molecular Cancer - October 24, 2013 Category: Cancer & Oncology Authors: King ChanChoi TingPui ChanMing LoKwok LoJayne CurryTomoko SmythAnne LeeWai NgGeorge TsaoRicky WongMaria LungNai Mak Source Type: research

The soluble Decoy receptor 3 is regulated by a PI3K-dependent mechanism and promotes migration and invasion in renal cell carcinoma
Conclusions: Taken together, our results identify DcR3 as a key driver of tumor cell dissemination and suggest DcR3 as a promising target for rational therapy of RCC.
Source: Molecular Cancer - October 10, 2013 Category: Cancer & Oncology Authors: Daniel WeissingerKatrin TagschererStephan Macher-GöppingerAxel HaferkampNina WagenerWilfried Roth Source Type: research

Lyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cells
Conclusions: The importance of Src family kinases and PKCssII in the initiation of the EGFR signaling pathway in lung tumor cells was demonstrated. We conclude that phosphorylation of EGFR is mediated through PKCssII regulation of Lyn activation, and occurs in association with RACK1 and Cbp/PAG proteins. We suggest that protein complexes in cell membranes, including lipid rafts, may serve as novel targets for combination therapies with EGFR and Src Family Kinase inhibitors in lung cancer.
Source: Molecular Cancer - July 16, 2013 Category: Cancer & Oncology Authors: Parnetta SuttonJeffrey BorgiaPhilip BonomiJanet Plate Source Type: research

Role of moesin in hyaluronan induced cell migration in glioblastoma multiforme
Conclusions: Our results suggest that development of inhibitors which interfere with CD44-moesin interactions may open a new avenue in the future to mitigate cellular migration in gliomas.
Source: Molecular Cancer - July 15, 2013 Category: Cancer & Oncology Authors: Leroi DeSouzaAjay MattaZia KarimJoydeep MukherjeeX WangOlga KrakovskaGelareh ZadehAbhijit GuhaKW Siu Source Type: research

Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner
Conclusions: Our findings suggest that Hh signaling modulates hypoxia induced pancreatic cancer EMT and invasion in a ligand-independent manner. Thus, Hh signaling may represent a promising therapeutic target for preventing pancreatic cancer progression.
Source: Molecular Cancer - June 20, 2013 Category: Cancer & Oncology Authors: Jianjun LeiJiguang MaQingyong MaXuqi LiHan LiuQinhong XuWanxing DuanQing SunJun XuZheng WuErxi Wu Source Type: research

Differential G protein subunit expression by prostate cancer cells and their interaction with CXCR5
Conclusions: These findings offer insight into molecular mechanisms of PCa progression and can help to design some therapeutic strategies involving CXCR5 and/or CXCL13 blockade and specific G protein inhibition to abrogate PCa metastasis.
Source: Molecular Cancer - June 18, 2013 Category: Cancer & Oncology Authors: Christelle El-HaibiPraveen SharmaRajesh SinghPranav GuptaDennis TaubShailesh SinghJames Lillard, Source Type: research

Phospholipid Scramblase 1, an interferon-regulated gene located at 3q23, is regulated by SnoN/SkiL in ovarian cancer cells
Conclusions: Our findings warrant further investigation into the role of PLSCR1 in ovarian cancer development and chemoresistance.
Source: Molecular Cancer - April 26, 2013 Category: Cancer & Oncology Authors: Karthik KodigepalliPavana AnurPaul SpellmanPeter SimsMeera Nanjundan Source Type: research

Epidermal growth factor receptor variant type III markedly accelerates angiogenesis and tumor growth via inducing c-myc mediated angiopoietin-like 4 expression in malignant glioma
Conclusions: In summary, we demonstrated that EGFRvIII induces Angptl4 expression through the ERK/c-Myc pathway and promotes tumor angiogenesis in malignant gliomas.
Source: Molecular Cancer - April 25, 2013 Category: Cancer & Oncology Authors: Yasufumi KatanasakaYasuo KoderaYuka KitamuraTatsuya MorimotoTomohide TamuraFumiaki Koizumi Source Type: research

Targeting the Vav3 oncogene enhances docetaxel-induced apoptosis through the inhibition of androgen receptor phosphorylation in LNCaP prostate cancer cells under chronic hypoxia
Conclusions: Interrupting Vav3 signaling enhances docetaxel-induced apoptosis in LNCaP cells under chronic hypoxia by inhibiting the PI3K/Akt, ERK, and AR signaling pathways. Therapy targeting Vav3 in combination with docetaxel may have practical implications for managing castration-resistant prostate cancer.
Source: Molecular Cancer - April 8, 2013 Category: Cancer & Oncology Authors: Takeo NomuraMutsushi YamasakiKenichi HiraiToru InoueRyuta SatoKeiko MatsuuraMasatsugu MoriyamaFuminori SatoHiromitsu Mimata Source Type: research

MicroRNA-497 increases apoptosis in MYCN amplified neuroblastoma cells by targeting the key cell cycle regulator WEE1
Conclusion: Our study’s results are consistent with miR-497 being a candidate tumor suppressor in neuroblastoma, through the direct targeting of WEE1. These findings re-enforce the proposal of WEE1 as a therapeutic target in neuroblastoma.
Source: Molecular Cancer - March 26, 2013 Category: Cancer & Oncology Authors: Laura CreeveyJacqueline RyanHarry HarveyIsabella BrayMaria MeehanAdnan KhanRaymond Stallings Source Type: research