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Source: Molecular Cancer

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Total 57 results found since Jan 2013.

TFAP2B overexpression contributes to tumor growth and a poor prognosis of human lung adenocarcinoma through modulation of ERK and VEGF/PEDF signaling
Background: TFAP2B is a member of the AP2 transcription factor family, which orchestrates a variety of cell processes. However, the roles of TFAP2B in regulating carcinogensis remain largely unknown. Here, we investigated the regulatory effects of TFAP2B on lung adenocarcinomas growth and identified the underlying mechanisms of actions in non-small cell lung cancer (NSCLC) cells. Methods: We first examined the expression of TFAP2B in lung cancer cell lines and tumor tissues. We also analyzed the prognostic predicting value of TFAP2B in lung adenocarcinomas. Then we investigated the molecular mechanisms by which TFAP2B knoc...
Source: Molecular Cancer - April 26, 2014 Category: Cancer & Oncology Authors: Lingyi FuKe ShiJingshu WangWangbing ChenDingbo ShiYun TianWei GuoWendan YuXiangsheng XiaoTiebang KangShusen WangWenlin HuangWuguo Deng Source Type: research

Integrated genomic analysis identifies the mitotic checkpoint kinase WEE1 as a novel therapeutic target in medulloblastoma
Conclusions: Taken together, these findings highlight mitotic kinases and, in particular, WEE1 as a rational therapeutic target for medulloblastoma.
Source: Molecular Cancer - March 24, 2014 Category: Cancer & Oncology Authors: Peter HarrisSujatha VenkataramanIrina AlimovaDiane BirksIlango BalakrishnanBrian CristianoAndrew DonsonAdrian DubucMichael TaylorNicholas ForemanPhilip ReiganRajeev Vibhakar Source Type: research

Matrine induces caspase-independent program cell death in hepatocellular carcinoma through bid-mediated nuclear translocation of apoptosis inducing factor
The objective of this study was to investigate the major determinant for the cell death induced by matrine in human hepatocellular carcinoma. We use human hepatocellular carcinoma cell line HepG2 and human hepatocellular carcinoma xenograft in nude mice as models to study the action of matrine in hepatocellular cancers. We found that caspase-dependent and -independent Program Cell Death (PCD) occurred in matrine-treated HepG2 cells, accompanied by the decreasing of mitochondrial transmembrane potential and the increasing ROS production. Further studies showed that AIF released from the mitochondria to the nucleus, and sile...
Source: Molecular Cancer - March 16, 2014 Category: Cancer & Oncology Authors: Huan ZhouMinying XuYa GaoZhigang DengHanwei CaoWenqing ZhangQiao WangBing ZhangGang SongYanyan ZhanTianhui Hu Source Type: research

Hypoxia differentially regulated CXCR4 and CXCR7 signaling in colon cancer
Background: HIF-1alpha and CXCR4/CXCL12 have crucial roles in the metastatic process of colorectal cancer. Our aim was to study the significance of targeting HIF-1alpha and the CXCR4/CXCL12 axis in colorectal cancer to prevent the dissemination process in vitro. Methods: We investigated CXCR4 and CXCR7 mRNA and protein expression in human colon carcinomas and the modulation of their expression by hypoxia and HIF-1alpha in colon cancer cell lines. The migration of tumor cells in a Boyden chamber was studied after CXCR4 inhibition with siRNA or the CXCR4/CXCL12 neutraligand, chalcone 4. Results: Analysis of a cohort of colon...
Source: Molecular Cancer - March 14, 2014 Category: Cancer & Oncology Authors: Benoît RomainMuriel Hachet-HaasSerge RohrCécile BrigandJean-Luc GalziMarie-Pierre GaubErwan PencreachDominique Guenot Source Type: research

Reduced expression of AMPK-beta1 during tumor progression enhances the oncogenic capacity of advanced ovarian cancer
AMP-activated protein kinase (AMPK) is a key energy sensor that is involved in regulating cell metabolism. Our previous study revealed that the subunits of the heterotimeric AMPK enzyme are diversely expressed during ovarian cancer progression. However, the impact of the variable expression of these AMPK subunits in ovarian cancer oncogenesis remains obscure. Here, we provide evidence to show that reduced expression of the AMPK-beta1 subunit during tumor progression is associated with the increased oncogenic capacity of advanced ovarian cancer cells. Immunohistochemical analysis revealed that AMPK-beta1 levels were reduced...
Source: Molecular Cancer - March 6, 2014 Category: Cancer & Oncology Authors: Cuilan LiVincent LiuPui ChiuKwok-Ming YaoHextan NganDavid Chan Source Type: research

Reduced expression of AMPK-ß1 during tumor progression enhances the oncogenic capacity of advanced ovarian cancer
AMP-activated protein kinase (AMPK) is a key energy sensor that is involved in regulating cell metabolism. Our previous study revealed that the subunits of the heterotimeric AMPK enzyme are diversely expressed during ovarian cancer progression. However, the impact of the variable expression of these AMPK subunits in ovarian cancer oncogenesis remains obscure. Here, we provide evidence to show that reduced expression of the AMPK-beta1 subunit during tumor progression is associated with the increased oncogenic capacity of advanced ovarian cancer cells. Immunohistochemical analysis revealed that AMPK-beta1 levels were reduced...
Source: Molecular Cancer - March 6, 2014 Category: Cancer & Oncology Authors: Cuilan LiVincent LiuPui ChiuKwok-Ming YaoHextan NganDavid Chan Source Type: research

cAMP signaling inhibits radiation-induced ATM phosphorylation leading to the augmentation of apoptosis in human lung cancer cells
Conclusions: cAMP signaling inhibits radiation-induced ATM activation by PKA-dependent activation of PP2A, and this signaling mechanism augments radiation-induced apoptosis by reducing ATM-dependent activation of NF-kappaB in lung cancer cells.
Source: Molecular Cancer - February 24, 2014 Category: Cancer & Oncology Authors: Eun-Ah ChoEui-Jun KimSahng-June KwakYong-Sung Juhnn Source Type: research

SNAI1 is critical for the aggressiveness of prostate cancer cells with low E-cadherin
Conclusions: Together, these results suggest that E-cadherin loss promotes SNAI1 expression that controls the aggressiveness of PCA cells.
Source: Molecular Cancer - February 24, 2014 Category: Cancer & Oncology Authors: Gagan DeepAnil JainAnand RamtekeHarold TingKavitha VijendraSubhash GangarChapla AgarwalRajesh Agarwal Source Type: research

WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration
Conclusion: Together, our data show a novel role for the WNK1/OSR1/NKCC1 pathway in basal and TMZ-induced glioma migration, and suggest that glioma treatment with TMZ might be improved by drugs that inhibit elements of the WNK1/OSR1/NKCC1 signaling pathway.
Source: Molecular Cancer - February 20, 2014 Category: Cancer & Oncology Authors: Wen ZhuGulnaz BegumKelli PointerPaul ClarkSung-Sen YangShih-Hua LinKristopher KahleJohn KuoDandan Sun Source Type: research

Integrated analysis of microRNA and mRNA expression and association with HIF binding reveals the complexity of microRNA expression regulation under hypoxia
Conclusions: Integrated analysis of microRNA, mRNA and ChIP-seq data in a model cell line supports the hypothesis that microRNA expression under hypoxia is regulated at transcriptional and post-transcriptional level, with the presence of HIF binding sites at microRNA genomic loci associated with up-regulation. The identification of hypoxia and HIF regulated microRNAs relevant for breast cancer is important for our understanding of disease development and design of therapeutic interventions.
Source: Molecular Cancer - February 11, 2014 Category: Cancer & Oncology Authors: Carme CampsHarpreet SainiDavid MoleHani ChoudhryMartin ReczkoJosé Afonso Guerra-AssunçãoYa-Min TianFrancesca BuffaAdrian HarrisArtemis HatzigeorgiouAnton EnrightJiannis Ragoussis Source Type: research

RNAi-mediated silencing of MLL-AF9 reveals leukemia-associated downstream targets and processes
Conclusion: Besides potential new therapeutic targets, the described transcription profile shaped by MLL-AF9 provides an information source into the molecular processes altered in MLL aberrant leukemia.
Source: Molecular Cancer - February 11, 2014 Category: Cancer & Oncology Authors: Katrin FleischmannPhilipp PagelIrene SchmidAdelbert Roscher Source Type: research

IL-1beta-induced activation of p38 promotes metastasis in gastric adenocarcinoma via upregulation of AP-1/c-fos, MMP2 and MMP9
Conclusions: IL-1beta-induced p38 activation and the IL-1beta/p38/AP-1(c-fos)/MMP2 & MMP9 pathway play an important role in metastasis in GA; this pathway may provide a novel therapeutic target for GA.
Source: Molecular Cancer - January 31, 2014 Category: Cancer & Oncology Authors: Qiaojia HuangFenghua LanXiaoting WangYinghao YuXuenong OuyangFeng ZhengJunyong HanYoudong LinYanchuan XieFeilai XieWei LiuXiaoli YangHan WangLihong DongLie WangJianming Tan Source Type: research

Reduced migration of MLH1 deficient colon cancer cells depends on SPTAN1
Conclusions: These data suggest that SPTAN1 levels decreased in concordance with MLH1 reduction and impaired cellular mobility in MLH1 deficient colon cancer cells. Therefore, aggressiveness of MLH1-positive CRC might be related to SPTAN1.
Source: Molecular Cancer - January 24, 2014 Category: Cancer & Oncology Authors: Inga HinrichsenBenjamin ErnstFranziska NuberSandra PassmannDieter SchäferVerena SteinkeNicolaus FriedrichsGuido PlotzStefan ZeuzemAngela Brieger Source Type: research

NF-kappa B mediated Up-regulation of CCCTC-binding factor in pediatric acute lymphoblastic leukemia
Conclusions: Our results indicate that CTCF serves as both an anti-apoptotic factor and a proliferative factor in leukemic cells. It potentially contributes to leukemogenesis through the NF-kappaB pathway in pediatric ALL patients.
Source: Molecular Cancer - January 7, 2014 Category: Cancer & Oncology Authors: Han ZhangLin ZhuHuacheng HeShanshan ZhuWei ZhangXiao LiuXiaoxi ZhaoChao GaoMei MeiShilai BaoHuyong Zheng Source Type: research

ZNF300P1 Encodes a lincRNA that regulates cell polarity and is epigenetically silenced in type II epithelial ovarian cancer
Conclusion: Our findings further support ZNF300P1 as frequently methylated in ovarian cancer and reveal a novel function for ZNF300P1 lincRNA expression in regulating cell polarity, motility, and adhesion and loss of expression may contribute to the metastatic potential of ovarian cancer cells.
Source: Molecular Cancer - January 6, 2014 Category: Cancer & Oncology Authors: Brian GlossKim Moran-JonesVita LinMaria GonzalezJames ScurryNeville HackerRobert SutherlandSusan ClarkGoli Samimi Source Type: research