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Source: Molecular Cancer

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Total 57 results found since Jan 2013.

Unravelling the enigma of siRNA and aptamer mediated therapies against pancreatic cancer
Pancreatic cancer (PC) is a fatal disease that has a poor 5-year survival rate. The poor prognosis can be attributed to both troublesome detections at the initial stage, which makes the majority of the treatme...
Source: Molecular Cancer - January 12, 2023 Category: Cancer & Oncology Authors: Zhe Liu, Neha Parveen, Urushi Rehman, Aisha Aziz, Afsana Sheikh, Mohammed A. S. Abourehab, Wei Guo, Junhao Huang, Zhenning Wang and Prashant Kesharwani Tags: Review Source Type: research

Hypoxia inducible prolyl hydroxylase PHD3 maintains carcinoma cell growth by decreasing the stability of p27
Conclusions: The data demonstrates that PHD3 can drive cell cycle entry at the G1/S transition through decreasing the half-life of p27 that occurs by attenuating p27S10 phosphorylation.
Source: Molecular Cancer - July 30, 2015 Category: Cancer & Oncology Authors: Heidi HögelPetra MiikkulainenLucia BinoPanu Jaakkola Source Type: research

The pseudokinase SgK223 promotes invasion of pancreatic ductal epithelial cells through JAK1/Stat3 signaling
Conclusions: Increased expression of SgK223 occurs in PDAC, and overexpression of SgK223 in pancreatic ductal epithelial cells promotes acquisition of a migratory and invasive phenotype through enhanced JAK1/Stat3 signaling. This represents the first association of SgK223 with a particular human cancer, and links SgK223 with a major signaling pathway strongly implicated in PDAC progression.
Source: Molecular Cancer - July 29, 2015 Category: Cancer & Oncology Authors: Carole TactacanYu PhuaLing LiuLuxi ZhangEmily HumphreyMark CowleyMark PineseAndrew BiankinRoger Daly Source Type: research

Bergapten drives autophagy through the up-regulation of PTEN expression in breast cancer cells
Conclusions: Our data indicate PTEN as a key target of Bergapten action in breast cancer cells for the induction of autophagy. These findings add further details on the mechanism of action of Bergapten, therefore suggesting that phytochemical compounds may be implemented in the novel strategies for breast cancer treatment.
Source: Molecular Cancer - July 7, 2015 Category: Cancer & Oncology Authors: Francesca De AmicisSaveria AquilaCatia MorelliCarmela GuidoMarta SantoroIda PerrottaLoredana MauroFrancesca GiordanoAlessandra NigroSebastiano AndòMaria Panno Source Type: research

Significance of filamin A in mTORC2 function in glioblastoma
Conclusions: Our results support FLNA as a new downstream effector of mTORC2 controlling GBM cell motility. This new mTORC2-FLNA signaling pathway plays important roles in motility and invasion of glioblastoma cells.
Source: Molecular Cancer - July 2, 2015 Category: Cancer & Oncology Authors: Naphat ChantaravisootPiriya WongkongkathepJoseph LooPaul MischelFuyuhiko Tamanoi Source Type: research

Genomic analysis and selective small molecule inhibition identifies BCL-X L as a critical survival factor in a subset of colorectal cancer
Conclusions: This work demonstrates the utility of characterizing frequent genomic alterations to identify cancer survival genes. In addition, these studies demonstrate the utility of the highly potent and selective compound A-1155463 for investigating the role of BCL-X L in mediating the survival of specific tumor types, and indicate that BCL-X L inhibition could be an effective treatment for colorectal tumors with high BCL-X L and NOXA expression.
Source: Molecular Cancer - July 2, 2015 Category: Cancer & Oncology Authors: Haichao ZhangJohn XuePaul HesslerStephen TahirJun ChenSha JinAndrew SouersJoel LeversonLloyd Lam Source Type: research

NOX1 to NOX2 switch deactivates AMPK and induces invasive phenotype in colon cancer cells through overexpression of MMP-7
Conclusions: Molecular switch from NOX1 to NOX2 in colon cancer cells induces ROS production and subsequently enhances MMP-7 expression by deactivating AMPK, which otherwise inhibits stimulus-induced autoregulation of ROS and NOX2 gene expression.
Source: Molecular Cancer - June 27, 2015 Category: Cancer & Oncology Authors: Suhrid BanskotaSushil RegmiJung-Ae Kim Source Type: research

GLIPR1-ΔTM synergizes with docetaxel in cell death and suppresses resistance to docetaxel in prostate cancer cells
Conclusions: Our data suggested that addition of GLIPR1-ΔTM treatment in PCa cells increases the efficacy of docetaxel and may inhibit the emergence of drug resistance; potentially permitting a decrease of docetaxel dose for patients with mCRPC eliminating its systemic toxicities.
Source: Molecular Cancer - June 19, 2015 Category: Cancer & Oncology Authors: Styliani KaranikaTheodoros KarantanosShinji KurosakaJianxiang WangTakahiro HirayamaGuang YangSanghee ParkAlexei GolstovRyuta TanimotoLikun LiTimothy Thompson Source Type: research

ZEB1 transcriptionally regulated carbonic anhydrase 9 mediates the chemoresistance of tongue cancer via maintaining intracellular pH
Conclusion: Our finding that tumor cells regulate pHi in response to chemotherapy provides new insights into mechanisms of drug resistance during cancer treatment. Identification of the ZEB1–CA9 signaling axis as a biomarker of poor prognosis in tongue cancer will be valuable in future development of therapeutic strategies aimed at improving treatment efficacy, especially in terms of drug resistance associated with this disease.
Source: Molecular Cancer - April 15, 2015 Category: Cancer & Oncology Authors: Guopei ZhengCong PengXiaoting JiaYixue GuZhijie ZhangYingen DengChengkun WangNan LiJiang YinXiaorong LiuMinying LuHailin TangZhimin He Source Type: research

Suppression of Aurora-A-FLJ10540 signaling axis prohibits the malignant state of head and neck cancer
Conclusion: Together, our findings define a novel mechanism by which Aurora-A promotes cell malignancy, with potential implications for understanding the clinical action of Aurora-A.
Source: Molecular Cancer - April 12, 2015 Category: Cancer & Oncology Authors: Chang-Han ChenAlice ChangShau-Hsuan LiHsin-Ting TsaiLi-Yen ShiuLi-Jen SuWen-Lung WangTai-Jen ChiuSheng-Dean LuoTai-Lin HuangChih-Yen Chien Source Type: research

miRNA-196b inhibits cell proliferation and induces apoptosis in HepG2 cells by targeting IGF2BP1
Conclusions: In conclusion, for the first time, we identified IGF2BP1 as a direct and functional target of miR-196b and showed that miR-196b overexpression reverses the chemoresistance induced by hypoxia. These results emphasize that the chemoresistance induced by hypoxia is a complex mechanism.
Source: Molecular Cancer - April 8, 2015 Category: Cancer & Oncology Authors: Magali RebucciAudrey SermeusElodie LeonardEdouard DelaiveMarc DieuMaude FransoletThierry ArnouldCarine Michiels Source Type: research

MicroRNA-223 delivered by platelet-derived microvesicles promotes lung cancer cell invasion via targeting tumor suppressor EPB41L3
Conclusions: Our study demonstrates for the first time that platelet-secreted miR-223 via P-MVs can promote lung cancer cell invasion via targeting tumor suppressor EPB41L3.
Source: Molecular Cancer - March 11, 2015 Category: Cancer & Oncology Authors: Hongwei LiangXin YanYi PanYongsheng WangNan WangLimin LiYuan LiuXi ChenChen-Yu ZhangHongwei GuKe Zen Source Type: research

Erk2 but not Erk1 regulates crosstalk between Met and EGFR in squamous cell carcinoma cell lines
Conclusions: These results identify Erk2 as the key downstream signal transducer between Met activation and EGFR ligand upregulation in squamous cell carcinoma cell lines derived from tongue, larynx and lung.
Source: Molecular Cancer - March 4, 2015 Category: Cancer & Oncology Authors: Simone GusenbauerEmanuele ZanuccoPjotr KnyazevAxel Ullrich Source Type: research

Vascular endothelial growth factor is an autocrine growth factor, signalling through neuropilin-1 in non-small cell lung cancer
Conclusions: Our data demonstrate that VEGF is an autocrine growth factor in NSCLC signaling, at least in part, through NP1. Targeting this VEGF receptor may offer potential as a novel therapeutic approach and also support the evaluation of the role of NP1 as a biomarker predicting sensitivity or resistance to VEGF and VEGFR-targeted therapies in the clinical arena.
Source: Molecular Cancer - February 20, 2015 Category: Cancer & Oncology Authors: Martin BarrSteven GrayKathy GatelyEmily HamsPadraic FallonAnthony DaviesDerek RichardGraham PidgeonKenneth O¿Byrne Source Type: research

Inhibition of nucleoporin member Nup214 expression by miR-133b perturbs mitotic timing and leads to cell death
Conclusions: We have identified NUP214, a member of the massive nuclear pore complex, as a novel miR-133b target. Thus, we have shown a hitherto unknown microRNA regulation of mitosis mediated by a member of the nucleoporin family. Based on observations, we also raise some hypotheses regarding transport-dependent/independent functions of Nup214 in this study. Our results hence attempt to explain why miR-133b is generally downregulated in tumours and lay out the potential for Nup214 as a therapeutic target in the treatment of cancer.
Source: Molecular Cancer - February 15, 2015 Category: Cancer & Oncology Authors: Sumana BhattacharjyaKumar RoyAbira GangulyShreya SarkarChinmay PandaDibyendu BhattacharyyaNitai BhattacharyyaSusanta Roychoudhury Source Type: research