Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner
Conclusions:
Our findings suggest that Hh signaling modulates hypoxia induced pancreatic cancer EMT and invasion in a ligand-independent manner. Thus, Hh signaling may represent a promising therapeutic target for preventing pancreatic cancer progression.
Source: Molecular Cancer - Category: Cancer & Oncology Authors: Jianjun LeiJiguang MaQingyong MaXuqi LiHan LiuQinhong XuWanxing DuanQing SunJun XuZheng WuErxi Wu Source Type: research