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MicroRNA-223 delivered by platelet-derived microvesicles promotes lung cancer cell invasion via targeting tumor suppressor EPB41L3
Conclusions: Our study demonstrates for the first time that platelet-secreted miR-223 via P-MVs can promote lung cancer cell invasion via targeting tumor suppressor EPB41L3.
Source: Molecular Cancer - March 11, 2015 Category: Cancer & Oncology Authors: Hongwei LiangXin YanYi PanYongsheng WangNan WangLimin LiYuan LiuXi ChenChen-Yu ZhangHongwei GuKe Zen Source Type: research

Erk2 but not Erk1 regulates crosstalk between Met and EGFR in squamous cell carcinoma cell lines
Conclusions: These results identify Erk2 as the key downstream signal transducer between Met activation and EGFR ligand upregulation in squamous cell carcinoma cell lines derived from tongue, larynx and lung.
Source: Molecular Cancer - March 4, 2015 Category: Cancer & Oncology Authors: Simone GusenbauerEmanuele ZanuccoPjotr KnyazevAxel Ullrich Source Type: research

Vascular endothelial growth factor is an autocrine growth factor, signalling through neuropilin-1 in non-small cell lung cancer
Conclusions: Our data demonstrate that VEGF is an autocrine growth factor in NSCLC signaling, at least in part, through NP1. Targeting this VEGF receptor may offer potential as a novel therapeutic approach and also support the evaluation of the role of NP1 as a biomarker predicting sensitivity or resistance to VEGF and VEGFR-targeted therapies in the clinical arena.
Source: Molecular Cancer - February 20, 2015 Category: Cancer & Oncology Authors: Martin BarrSteven GrayKathy GatelyEmily HamsPadraic FallonAnthony DaviesDerek RichardGraham PidgeonKenneth O¿Byrne Source Type: research

Nicotine-mediated invasion and migration of non-small cell lung carcinoma cells by modulating STMN3 and GSPT1 genes in an ID1-dependent manner
Conclusions: Collectively, our data suggests that nicotine and EGF induce genes such as STMN3 and GSPT1 to promote the proliferation, invasion and migration of NSCLC, thus enhancing their tumorigenic properties. These studies thus reveal a central role for ID1 and its downstream targets in facilitating lung cancer progression.
Source: Molecular Cancer - July 16, 2014 Category: Cancer & Oncology Authors: Sajitha NairNamrata Bora-SinghalDeepak PerumalSrikumar Chellappan Source Type: research

TFAP2B overexpression contributes to tumor growth and a poor prognosis of human lung adenocarcinoma through modulation of ERK and VEGF/PEDF signaling
Background: TFAP2B is a member of the AP2 transcription factor family, which orchestrates a variety of cell processes. However, the roles of TFAP2B in regulating carcinogensis remain largely unknown. Here, we investigated the regulatory effects of TFAP2B on lung adenocarcinomas growth and identified the underlying mechanisms of actions in non-small cell lung cancer (NSCLC) cells. Methods: We first examined the expression of TFAP2B in lung cancer cell lines and tumor tissues. We also analyzed the prognostic predicting value of TFAP2B in lung adenocarcinomas. Then we investigated the molecular mechanisms by which TFAP2B knoc...
Source: Molecular Cancer - April 26, 2014 Category: Cancer & Oncology Authors: Lingyi FuKe ShiJingshu WangWangbing ChenDingbo ShiYun TianWei GuoWendan YuXiangsheng XiaoTiebang KangShusen WangWenlin HuangWuguo Deng Source Type: research

cAMP signaling inhibits radiation-induced ATM phosphorylation leading to the augmentation of apoptosis in human lung cancer cells
Conclusions: cAMP signaling inhibits radiation-induced ATM activation by PKA-dependent activation of PP2A, and this signaling mechanism augments radiation-induced apoptosis by reducing ATM-dependent activation of NF-kappaB in lung cancer cells.
Source: Molecular Cancer - February 24, 2014 Category: Cancer & Oncology Authors: Eun-Ah ChoEui-Jun KimSahng-June KwakYong-Sung Juhnn Source Type: research

Lyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cells
Conclusions: The importance of Src family kinases and PKCssII in the initiation of the EGFR signaling pathway in lung tumor cells was demonstrated. We conclude that phosphorylation of EGFR is mediated through PKCssII regulation of Lyn activation, and occurs in association with RACK1 and Cbp/PAG proteins. We suggest that protein complexes in cell membranes, including lipid rafts, may serve as novel targets for combination therapies with EGFR and Src Family Kinase inhibitors in lung cancer.
Source: Molecular Cancer - July 16, 2013 Category: Cancer & Oncology Authors: Parnetta SuttonJeffrey BorgiaPhilip BonomiJanet Plate Source Type: research