Vascular endothelial growth factor is an autocrine growth factor, signalling through neuropilin-1 in non-small cell lung cancer

Conclusions: Our data demonstrate that VEGF is an autocrine growth factor in NSCLC signaling, at least in part, through NP1. Targeting this VEGF receptor may offer potential as a novel therapeutic approach and also support the evaluation of the role of NP1 as a biomarker predicting sensitivity or resistance to VEGF and VEGFR-targeted therapies in the clinical arena.
Source: Molecular Cancer - Category: Cancer & Oncology Authors: Source Type: research