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MicroRNA-363 targets myosin 1B to reduce cellular migration in head and neck cancer
Conclusions: These findings demonstrate that the overexpression of miR-363 reduces cellular migration in head and neck cancer and reveal the biological relationship between miR-363, myosin 1b, and HPV-positive SCCHN.
Source: BMC Cancer - November 6, 2015 Category: Cancer & Oncology Authors: Bhavana ChapmanAbigail WaldParvez AkhtarAna MunkoJingjing XuSandra GibsonJennifer GrandisRobert FerrisSaleem Khan Source Type: research

Identification and validation of dysregulated MAPK7 (ERK5) as a novel oncogenic target in squamous cell lung and esophageal carcinoma
Conclusions: Together, these data highlight a broader role for dysregulated MAPK7 in driving tumorigenesis within niche populations of highly prevalent tumor types, and describe current efforts in establishing a robust drug discovery screening cascade.
Source: BMC Cancer - June 4, 2015 Category: Cancer & Oncology Authors: Paul GavineMei WangDehua YuEva HuChunlei HuangJenny XiaXinying SuJoan FanTianwei ZhangQingqing YeLi ZhengGuanshan ZhuZiliang QianQingquan LuoYing HouQunsheng Ji Source Type: research

Wilms’ tumor gene 1 regulates p63 and promotes cell proliferation in squamous cell carcinoma of the head and neck
Conclusions: Our findings suggest that WT1 and p63 act as oncogenes in SCCHN, affecting multiple genes involved in cancer cell growth.
Source: BMC Cancer - May 1, 2015 Category: Cancer & Oncology Authors: Xingru LiSofia OttossonSihan WangEmma JernbergLinda BoldrupXiaolian GuKarin NylanderAihong Li Source Type: research

MiR-130b plays an oncogenic role by repressing PTEN expression in esophageal squamous cell carcinoma cells
Conclusion: The results indicate that miR-130b plays an oncogenic role in ESCC cells by repressing PTEN expression and Akt phosphorylation, which would be helpful in developing miRNA-based treatments for ESCC.
Source: BMC Cancer - January 31, 2015 Category: Cancer & Oncology Authors: Tingting YuRisheng CaoShuo LiMingen FuLihua RenWeixu ChenHong ZhuQiang ZhanRuihua Shi Source Type: research

Role of LPAR3, PKC and EGFR in LPA-induced cell migration in oral squamous carcinoma cells
Conclusion: The results demonstrate LPA-stimulated migration in oral carcinoma cells through LPAR3, mediated further by PKC, which acts either in concert with or independently of EGFR transactivation.
Source: BMC Cancer - June 13, 2014 Category: Cancer & Oncology Authors: Ingvild BrusevoldIngun TveteraasMonica AasrumJohn ØdegårdDagny SandnesThoralf Christoffersen Source Type: research

Effect of hypoxia on the expression of ¿B-crystallin in head and neck squamous cell carcinoma
Conclusions: We provide the first evidence that hypoxia stimulates upregulation of αB-crystallin in HNSCC. This upregulation was not caused by the low oxygen pressure, but more likely by ROS formation. The higher expression of αB-crystallin may lead to prolonged survival of these cells under hypoxic conditions.
Source: BMC Cancer - April 11, 2014 Category: Cancer & Oncology Authors: Chantal van de SchootbruggeElisabeth SchultsJohan BussinkPaul SpanReidar GrénmanGer PruijnJohannes KaandersWilbert Boelens Source Type: research

Effect of hypoxia on the expression of alphaB-crystallin in head and neck squamous cell carcinoma
Conclusions: We provide the first evidence that hypoxia stimulates upregulation of alphaB-crystallin in HNSCC. This upregulation was not caused by the low oxygen pressure, but more likely by ROS formation. The higher expression of alphaB-crystallin may lead to prolonged survival of these cells under hypoxic conditions.
Source: BMC Cancer - April 11, 2014 Category: Cancer & Oncology Authors: Chantal van de SchootbruggeElisabeth SchultsJohan BussinkPaul SpanReidar GrénmanGer PruijnJohannes KaandersWilbert Boelens Source Type: research

Role of Pax8 in the regulation of MET and RON receptor Tyrosine Kinases in non-small cell lung cancer
Conclusion: PAX8 provides signals for growth and motility of NSCLC cells and is necessary for MET and RON expression. Further investigations are necessary to investigate the therapeutic potential of PA8 in NSCLC.
Source: BMC Cancer - March 14, 2014 Category: Cancer & Oncology Authors: Rajani KantetiEssam El-HashaniImmanuel DhanasinghMaria TretiakovaAliya HusainSherven SharmaJay SharmaEverett VokesRavi Salgia Source Type: research

High expression of wee1 is associated with malignancy in vulvar squamous cell carcinoma patients
Conclusions: Our results suggest that Wee1 may be involved in the progression of vulvar carcinomas. Based on our in vitro results, Wee1 is unlikely to function as a target for mono-treatment of these patients.
Source: BMC Cancer - June 14, 2013 Category: Cancer & Oncology Authors: Gry MagnussenEllen HellesyltJahn NeslandClaes TropeVivi FlørenesRuth Holm Source Type: research