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Nicotine exacerbates diabetic nephropathy through upregulation of Grem1 expression
CONCLUSION: Grem1 plays a vital role in nicotine-exacerbated DN. Grem1 may be a potential therapeutic target for chronic smokers with DN.PMID:37415117 | DOI:10.1186/s10020-023-00692-9
Source: Molecular Medicine - July 6, 2023 Category: Molecular Biology Authors: Jianning Chen Haiting Xiao Rui Xue Vinod Kumar Rukhsana Aslam Syed Faizan Mehdi Huairong Luo Ashwani Malhotra Xiqian Lan Pravin Singhal Source Type: research

nAChR signaling regulates IRE1 α activation to protect β cells against terminal unfolded protein response under irremediable ER stress
ConclusionsOur findings suggest that nAChR signaling regulates IRE1 α activation to protect β cells from the T‐UPR and apoptosis under ER stress partly through α7 nAChR. Targeting nAChR signaling to inhibit the T‐UPR cascade may therefore hold therapeutic promise by thwarting β cell death in diabetes.
Source: Journal of Diabetes Investigation - January 9, 2020 Category: Endocrinology Authors: Tatsuya Ishibashi, Shuhei Morita, Shohei Kishimoto, Shinsuke Uraki, Ken Takeshima, Yasushi Furukawa, Hidefumi Inaba, Hiroyuki Ariyasu, Hiroshi Iwakura, Hiroto Furuta, Masahiro Nishi, Feroz R. Papa, Takashi Akamizu Tags: ORIGINAL ARTICLE Source Type: research

Nicotine Enhances Mesangial Cell Proliferation and Fibronectin Production in High Glucose Milieu via Activation of Wnt/ β-catenin Pathway.
In this study, we examined the involvement of Wnt/β-catenin pathway in nicotine-mediated mesangial cell growth in high glucose milieu. Primary human renal mesangial cells were treated with nicotine in the presence of normal (5 mM) or high glucose (30 mM) followed by evaluation for cell growth. In the presence of normal glucose, nicotine increased both the total cell numbers and Ki-67 positive cell ratio, indicating that nicotine stimulated mesangial cell proliferation. Although high glucose itself also stimulated mesangial cell proliferation, nicotine further enhanced the mitogenic effect of high glucose. Similarly, nicot...
Source: Bioscience Reports - March 23, 2018 Category: Biomedical Science Authors: Lan X, Wen H, Aslam R, Marashi Shoshtari SS, Mishra A, Kumar V, Wang H, Wu G, Luo H, Malhotra A, Singhal PC Tags: Biosci Rep Source Type: research

Abstract P162: Nicotine via Cd36, Cox2 and Oxidative Stress Promotes Podocyte Injury: Link Between E-cigarettes and Renal Disease Progression? Session Title: Chronic Kidney and Renal
Conclusion: NIC activated in human POD a reciprocal interplay between NADPH oxidases and COX2 that increased O2- production, reduced Synpo and upregulated the B scavenger receptor CD36 that, via increased uptake of oxidized LDL, promoted podocyte apoptosis. We surmise that these novel findings implicate NIC as a risk factor for CVD and CKD progression.
Source: Hypertension - November 3, 2015 Category: Cardiology Authors: Raij, L., Tian, R., Zhou, M.-S. Tags: Session Title: Chronic Kidney and Renal Source Type: research