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Drug: Melatonin

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Total 136 results found since Jan 2013.

Melatonin Inhibits OGD/R-Induced H9c2 Cardiomyocyte Pyroptosis via Regulation of MT2/miR-155/FOXO3a/ARC Axis
Int Heart J. 2022;63(2):327-337. doi: 10.1536/ihj.21-571.ABSTRACTEmerging literature suggests that pyroptosis plays a critical role in ischemia/hypoxia (I/R) -induced myocardial injury. Melatonin has been implicated in attenuating I/R-induced injury of cardiomyocytes. Nevertheless, whether melatonin inhibits I/R-induced pyroptosis of cardiomyocytes and the underlying molecular mechanisms remain unexploited.H9c2 cardiomyocytes were cultured under oxygen-glucose deprivation/reperfusion (OGD/R) condition to establish a myocardial pyroptosis model in vitro. OGD/R-induced pyroptosis was evaluated by CCK-8 assay, IL-1β and IL-1...
Source: International Heart Journal - March 31, 2022 Category: Cardiology Authors: Rui Chen Min Yang Source Type: research

Melatonin induces apoptosis of colorectal cancer cells through HDAC4 nuclear import mediated by CaMKII inactivation
In conclusion, the present study provides evidence that melatonin‐induced apoptosis in colorectal cancer LoVo cells largely depend on the nuclear import of HDAC4 and subsequent H3 deacetylation via the inactivation of CaMKIIα. This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - March 1, 2015 Category: Research Authors: Jia‐Yi Wei, Wan‐Ming Li, Lin‐Lin Zhou, Qiu‐Nan Lu, Wei He Tags: Original Article Source Type: research

Involvement of ROS-alpha v beta 3 integrin-FAK/Pyk2 in the inhibitory effect of melatonin on U251 glioma cell migration and invasion under hypoxia
Conclusions: These results suggest that melatonin exerts anti-migratory and anti-invasive effects on glioma cells in response to hypoxia via ROS-αvβ3 integrin-FAK/Pyk2 signaling pathways. This provides evidence that melatonin may be a potential therapeutic molecule targeting the hypoxic microenvironment of glioma.
Source: Epidemiologic Perspectives and Innovations - March 20, 2015 Category: Epidemiology Authors: Cheng-Shi XuZe-Fen WangXiao-Dong HuangLi-Ming DaiChang-Jun CaoZhi-Qiang Li Source Type: research

Membrane receptor‐dependent Notch1/Hes1 activation by melatonin protects against myocardial ischemia reperfusion injury: in vivo and in vitro studies
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - August 26, 2015 Category: Research Authors: Liming Yu, Hongliang Liang, Zhihong Lu, Guolong Zhao, Mengen Zhai, Yang Yang, Jian Yang, Dinghua Yi, Wensheng Chen, Xiaowu Wang, Weixun Duan, Zhenxiao Jin, Shiqiang Yu Tags: Original Article Source Type: research

Involvement of nuclear receptor RZR/RORγ in melatonin-induced HIF-1α inactivation in SGC-7901 human gastric cancer cells.
Authors: Wang RX, Liu H, Xu L, Zhang H, Zhou RX Abstract The melatonin nuclear receptor is an orphan member of the nuclear receptor superfamily RZR/ROR, which consists of three subtypes (α, β and γ), suggesting that immunomodulatory and antitumor effects through the intracellular action of melatonin depend on nuclear signaling. In the present study, the biological mechanisms of melatonin were elucidated in association with the RZR/RORγ pathway in SGC-7901 human gastric cancer cells under hypoxia. Melatonin suppressed the activity of RZR/RORγ and SUMO-specific protease 1 (SENP1) signaling pathway, which is esse...
Source: Oncology Reports - September 6, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Melatonin enhances arsenic trioxide-induced cell death via sustained upregulation of Redd1 expression in breast cancer cells
Publication date: Available online 27 November 2015 Source:Molecular and Cellular Endocrinology Author(s): Sun-Mi Yun, Sang Hyeok Woo, Sang Taek Oh, Sung-Eun Hong, Tae-Boo Choe, Sang-Kyu Ye, Eun-Kyu Kim, Min Ki Seong, Hyun-A Kim, Woo Chul Noh, Jin Kyung Lee, Hyeon-Ok Jin, Yun-Han Lee, In-Chul Park Melatonin is implicated in various physiological functions, including anticancer activity. However, the mechanism(s) of its anticancer activity is not well understood. In the present study, we investigated the combined effects of melatonin and arsenic trioxide (ATO) on cell death in human breast cancer cells. Mela...
Source: Molecular and Cellular Endocrinology - November 27, 2015 Category: Endocrinology Source Type: research

Melatonin Attenuates Early Brain Injury via the Melatonin Receptor/Sirt1/NF-κB Signaling Pathway Following Subarachnoid Hemorrhage in Mice
In conclusion, our results demonstrate that Mel attenuates EBI following SAH via the MR/Sirt1/NF-κB signaling pathway.
Source: Molecular Neurobiology - February 11, 2016 Category: Neurology Source Type: research

Melatonin protects hepatocytes against bile acid-induced mitochondrial oxidative stress via the AMPK-SIRT3-SOD2 pathway.
This study investigates the protective effects of melatonin pretreatment on glycochenodeoxycholic acid (GCDCA)-induced hepatotoxicity and elucidates the potential mechanism of melatonin-mediated protection. Melatonin markedly decreased mitochondrial ROS (mROS) production in L02 cells treated with 100 μM GCDCA, and inhibited GCDCA-stimulated cytotoxicity. Notably, melatonin exerted its hepatoprotective effects by upregulating sirtuin 3 (SIRT3) activity and its expression level, thus regulating superoxide dismutase 2 (SOD2) acetylation and inhibiting the production of mROS induced by GCDCA. Moreover, siRNA targeting SIRT3 b...
Source: Free Radical Research - February 18, 2016 Category: Research Tags: Free Radic Res Source Type: research