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Drug: Amitriptyline
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Total 8 results found since Jan 2013.
Therapeutic potential of amitriptyline for paraquat-induced pulmonary fibrosis: Involvement of caveolin-1-mediated anti-epithelial-mesenchymal transition and inhibition of apoptosis
CONCLUSION: AMT inhibited PQ-induced EMT in A549 cells and improved lung histopathology and oxygenation in mice by up-regulating caveolin-1.PMID:36898313 | DOI:10.1016/j.ecoenv.2023.114732
Source: Ecotoxicology and Environmental Safety - March 10, 2023 Category: Environmental Health Authors: Jianshi Chen Xiangdong Jian Chunmei Li Bihuang Cheng Source Type: research
Downregulation of connexin 43 potentiates amitriptyline-induced brain-derived neurotrophic factor expression in primary astrocytes through lysophosphatidic acid receptor < sub > 1/3 < /sub > , Src, and extracellular signal-regulated kinase
Eur J Pharmacol. 2022 Apr 28:174986. doi: 10.1016/j.ejphar.2022.174986. Online ahead of print.ABSTRACTConnexin 43 (Cx43) expression is decreased in the prefrontal cortex of patients with depression, but its significance is still unknown. Neurotrophic factors, such as brain-derived neurotrophic factor (BDNF), are involved in the effects of antidepressant. However, the relationship between Cx43 expression and induction of brain-derived neurotrophic factor production by antidepressants is unknown. On the basis of our previous study, which showed that adrenergic receptors stimulation results in potentiation of BDNF expression ...
Source: European Journal of Pharmacology - May 1, 2022 Category: Drugs & Pharmacology Authors: Nozomi Tokunaga Tomoyo Takimoto Yoki Nakamura Kazue Hisaoka-Nakashima Norimitsu Morioka Source Type: research
Endothelial NLRP3 inflammasome activation and arterial neointima formation associated with acid sphingomyelinase during hypercholesterolemia
Publication date: October 2017 Source:Redox Biology, Volume 13 Author(s): Saisudha Koka, Min Xia, Yang Chen, Owais M. Bhat, Xinxu Yuan, Krishna M. Boini, Pin-Lan Li The NLRP3 inflammasome has been reported to be activated by atherogenic factors, whereby endothelial injury and consequent atherosclerotic lesions are triggered in the arterial wall. However, the mechanisms activating and regulating NLRP3 inflammasomes remain poorly understood. The present study tested whether acid sphingomyelinase (ASM) and ceramide associated membrane raft (MR) signaling platforms contribute to the activation of NLRP3 inflammasomes and ather...
Source: Redox Biology - June 19, 2017 Category: Biology Source Type: research
Amitriptyline Activates TrkA to Aid Neuronal Growth and Attenuate Anesthesia-Induced Neurodegeneration in Rat Dorsal Root Ganglion Neurons
Abstract: Tricyclic antidepressant amitriptyline (AM) has been shown to exert neurotrophic activity on neurons. We thus explored whether AM may aid the neuronal development and protect anesthesia-induced neuro-injury in young spinal cord dorsal root ganglion (DRG) neurons.
The DRG explants were prepared from 1-day-old rats. The effect of AM on aiding DRG neural development was examined by immunohistochemistry at dose-dependent manner. AM-induced changes in gene and protein expressions, and also phosphorylation states of tyrosine kinases receptor A (TrkA) and B (TrkB) in DRG, were examined by quantitative real-time polymer...
Source: Medicine - May 1, 2016 Category: Internal Medicine Tags: Research Article: Meta-Analysisof Observ Studiesin Epidemiology Source Type: research
Fibroblast growth factor 2 mRNA expression evoked by amitriptyline involves extracellular signal‐regulated kinase‐dependent early growth response 1 production in rat primary cultured astrocytes
This study defined the signaling cascade that mediates amitriptyline‐induced FGF2 production in rat primary cultured astrocytes. Amitriptyline treatment significantly increased early growth response 1 (EGR1), a transcription factor known to regulate FGF2 expression. Knockdown of EGR1 using siRNA blocked amitriptyline‐evoked FGF2 mRNA expression. Treatment with several different classes of antidepressants leads to expression of EGR1 mRNA as well as FGF2 mRNA. These results confirm that EGR1 production is likely to be indispensable for the amitriptyline‐evoked FGF2 mRNA expression. Signal transduction inhibitors were u...
Source: Journal of Neurochemistry - August 6, 2015 Category: Neurology Authors: Naoto Kajitani, Kazue Hisaoka‐Nakashima, Mami Okada‐Tsuchioka, Mayu Hosoi, Toshiki Yokoe, Norimitsu Morioka, Yoshihiro Nakata, Minoru Takebayashi Tags: Original Article Source Type: research
Fibroblast growth factor 2 mRNA expression evoked by amitriptyline involves ERK‐dependent EGR1 production in rat primary cultured astrocytes
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - July 16, 2015 Category: Neurology Authors: Naoto Kajitani, Kazue Hisaoka‐Nakashima, Mami Okada‐Tsuchioka, Mayu Hosoi, Toshiki Yokoe, Norimitsu Morioka, Yoshihiro Nakata, Minoru Takebayashi Tags: Original Article Source Type: research
Antidepressants activate the lysophosphatidic acid receptor LPA1 to induce insulin-like growth factor-I receptor transactivation, stimulation of ERK1/2 signaling and cell proliferation in CHO-K1 fibroblasts.
Abstract
Different lines of evidence indicate that the lysophosphatidic acid (LPA) receptor LPA1 is involved in neurogenesis, synaptic plasticity and anxiety-related behaviour, but little is known on whether this receptor can be targeted by neuropsychopharmacological agents. The present study investigated the effects of different antidepressants on LPA1 signaling. We found that in Chinese hamster ovary (CHO)-K1 fibroblasts expressing endogenous LPA1 tricyclic and tetracyclic antidepressants and fluoxetine induced the phosphorylation of extracellular signal-regulated kinase1/2 (ERK1/2) and CREB. This response was a...
Source: Biochemical Pharmacology - April 15, 2015 Category: Drugs & Pharmacology Authors: Olianas MC, Dedoni S, Onali P Tags: Biochem Pharmacol Source Type: research
