Filtered By:
Drug: Docetaxel
This page shows you your search results in order of date. This is page number 6.
Order by Relevance | Date
Total 178 results found since Jan 2013.
LncRNA LINC00184 promotes docetaxel resistance and immune escape via miR-105-5p/PD-L1 axis in prostate cancer
CONCLUSIONS: LINC00184 promoted docetaxel resistance and immune escape in prostate cancer cells by adsorption of miR-105-5p, resulted in upregulation of the expression of PD-L1. LINC00184 could possibly be considered as a potential target for treatment in prostate cancer patients with docetaxel-resistance.PMID:34896914 | DOI:10.1016/j.imbio.2021.152163
Source: Immunobiology - December 13, 2021 Category: Allergy & Immunology Authors: Wei Zhang Jun Xin Jinjin Lai Wenbin Zhang Source Type: research
Docetaxel-triggered SIDT2/NOX4/JNK/HuR signaling axis is associated with TNF- α-mediated apoptosis of cancer cells
Biochem Pharmacol. 2021 Dec 2:114865. doi: 10.1016/j.bcp.2021.114865. Online ahead of print.ABSTRACTPrevious studies have confirmed that docetaxel (DTX) treatment increases TNF-α production in cancer cells, but its mechanism of action remains unclear. Therefore, this study aimed to determine the signaling axis by which DTX induced the expression of TNF-α in U937 leukemia and MCF-7 breast carcinoma cells. DTX treatment promoted Ca2+-controlled autophagy and SIDT2 expression, resulting in lysosomal degradation of miR-25 in U937 cells. Downregulation of miR-25 increased NOX4 mRNA stability and protein expression. NOX4-stimu...
Source: Biochemical Pharmacology - December 5, 2021 Category: Drugs & Pharmacology Authors: Liang-Jun Wang Jing-Ting Chiou Yuan-Chin Lee Long-Sen Chang Source Type: research
ChaC glutathione specific γ-glutamylcyclotransferase 1 inhibits cell viability and increases the sensitivity of prostate cancer cells to docetaxel by inducing endoplasmic reticulum stress and ferroptosis
Exp Ther Med. 2021 Sep;22(3):997. doi: 10.3892/etm.2021.10429. Epub 2021 Jul 15.ABSTRACTThe present study aimed to determine the effects and mechanism of ChaC glutathione specific γ-glutamylcyclotransferase 1 (CHAC1) on cell viability and the sensitivity of prostate cancer cells to docetaxel. Compared with non-tumor human prostate epithelial RWPE-1 cells, the mRNA and protein levels of CHAC1 significantly decreased in two prostate cancer cell lines, DU145 and 22RV1, as measured by quantitative polymerase chain reaction and western blot analysis (P<0.05). The cell viability and glutathione (GSH) levels were significantl...
Source: Experimental and Therapeutic Medicine - August 4, 2021 Category: General Medicine Authors: Saifei He Miao Zhang Ying Ye Juhua Zhuang Xing Ma Yanan Song Wei Xia Source Type: research
Overexpression of claspin promotes docetaxel resistance and is associated with prostate ‐specific antigen recurrence in prostate cancer
Claspin overexpression was related to poor PSA relapse-free prognosis. Claspin knockdown significantly upregulated the sensitivity to docetaxel in DU145 docetaxel-resistant cells. AbstractAlthough docetaxel (DTX) confers significant survival benefits in patients with castration-resistant prostate cancer (CRPC), resistance to DTX inevitably occurs. Therefore, clarifying the mechanisms of DTX resistance may improve survival in patients with CRPC. Claspin plays a pivotal role in DNA replication stress and damage responses and is an essential regulator for the S-phase checkpoint.CLSPN is an oncogenic gene that contributes to t...
Source: Cancer Medicine - July 9, 2021 Category: Cancer & Oncology Authors: Takashi Babasaki,
Kazuhiro Sentani,
Yohei Sekino,
Go Kobayashi,
Quoc Thang Pham,
Narutaka Katsuya,
Shintaro Akabane,
Daiki Taniyama,
Tetsutaro Hayashi,
Masaki Shiota,
Naohide Oue,
Jun Teishima,
Akio Matsubara,
Wataru Yasui Tags: ORIGINAL RESEARCH Source Type: research
Developmentally regulated GTP-binding protein 2 levels in prostate cancer cell lines impact docetaxel-induced apoptosis
CONCLUSIONS: In prostate cancer cells, DRG2 regulates G2/M arrest after docetaxel treatment. In prostate cancer cells with DRG2 knockdown, apoptosis increases without G2/M arrest in response to docetaxel treatment. These results show that inhibition of DRG2 expression can be useful to enhance docetaxel-induced apoptosis despite low-dose administration in castration-resistant prostate cancer.PMID:34190439 | DOI:10.4111/icu.20200574
Source: Clinical Prostate Cancer - June 30, 2021 Category: Cancer & Oncology Authors: Seong Cheol Kim Won Hyeok Lee Song Hee Kim Abdumadjidov Alisher Abdulkhayevich Jeong Woo Park Young Min Kim Kyung Hyun Moon Sang Hun Lee Sungchan Park Source Type: research
MicroRNA-224 modulates chemosensitivity of breast cancer cells to docetaxel by apoptosis inhibitor 5
CONCLUSION: An inverse association between miR-224 and API-5 in breast cancer cells was revealed. Dysregulation of miR-224 plays a vital role in the acquired DOC resistance of breast cancer and at least partially via targeting API-5.PMID:34076992
Source: Journal of B.U.ON. - June 2, 2021 Category: Cancer & Oncology Authors: Junying Zhang Ya Lu Ye Zhang Yan Chen Wenbo Zhu Hangju Zhu Jianzhong Wu Jinhai Tang Source Type: research
