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Drug: Docetaxel

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Total 178 results found since Jan 2013.

MicroRNA-224 modulates chemosensitivity of breast cancer cells to docetaxel by apoptosis inhibitor 5
CONCLUSION: An inverse association between miR-224 and API-5 in breast cancer cells was revealed. Dysregulation of miR-224 plays a vital role in the acquired DOC resistance of breast cancer and at least partially via targeting API-5.PMID:34076992
Source: Journal of B.U.ON. - June 2, 2021 Category: Cancer & Oncology Authors: Junying Zhang Ya Lu Ye Zhang Yan Chen Wenbo Zhu Hangju Zhu Jianzhong Wu Jinhai Tang Source Type: research

LncRNA LINC00184 promotes docetaxel resistance and immune escape via miR-105-5p/PD-L1 axis in prostate cancer
CONCLUSIONS: LINC00184 promoted docetaxel resistance and immune escape in prostate cancer cells by adsorption of miR-105-5p, resulted in upregulation of the expression of PD-L1. LINC00184 could possibly be considered as a potential target for treatment in prostate cancer patients with docetaxel-resistance.PMID:34896914 | DOI:10.1016/j.imbio.2021.152163
Source: Immunobiology - December 13, 2021 Category: Allergy & Immunology Authors: Wei Zhang Jun Xin Jinjin Lai Wenbin Zhang Source Type: research

The CCL2-CCR2 Axis Contributes to Migration of Cabazitaxel-resistant Prostate Cancer Cells
CONCLUSION: The CCL2-CCR2 axis is a key contributor to resistance to the antimigration effect of cabazitaxel in prostate cancer cells. CCL2-CCR2 axis inhibition may be a potential therapeutic target against chemoresistant CRPC in combination with cabazitaxel.PMID:37247914 | DOI:10.21873/anticanres.16423
Source: Cell Research - May 29, 2023 Category: Cytology Authors: Ariunbold Natsagdorj Kouji Izumi Kaoru Hiratsuka Renato Naito Suguru Kadomoto Hiroaki Iwamoto Hiroshi Yaegashi Kazuyoshi Shigehara Hiroki Nakata Atsushi Mizokami Source Type: research

Androgen receptor knockdown enhances prostate cancer chemosensitivity by down ‐regulating FEN1 through the ERK/ELK1 signalling pathway
ConclusionCollectively, our studies demonstrate that AR knockdown improves the DTX sensitivity of prostate cancer cells by downregulating FEN1 through the ERK/ELK1 signalling pathway.
Source: Cancer Medicine - June 16, 2023 Category: Cancer & Oncology Authors: Weijie Xie, Shulin Li, Huan Guo, Jiawei Zhang, Menjiang Tu, Rui Wang, Bingling Lin, Yuqi Wu, Xiangwei Wang Tags: RESEARCH ARTICLE Source Type: research

TR4 Promotes Chemoresistance in PCa Stem Cells Gene Regulation
Prostate cancer (PCa) stem/progenitor cells are known to have higher chemoresistance than non-stem/progenitor cells, but the underlying molecular mechanism remains unclear. We found the expression of testicular nuclear receptor 4 (TR4) is significantly higher in PCa CD133+ stem/progenitor cells compared with CD133− non-stem/progenitor cells. Knockdown of TR4 levels in the established PCa stem/progenitor cells and the CD133+ population of the C4-2 PCa cell line with lentiviral TR4 siRNA led to increased drug sensitivity to the two commonly used chemotherapeutic drugs, docetaxel and etoposide, judging from significantly re...
Source: Journal of Biological Chemistry - June 7, 2013 Category: Chemistry Authors: Yang, D.-R., Ding, X.-F., Luo, J., Shan, Y.-X., Wang, R., Lin, S.-J., Li, G., Huang, C.-K., Zhu, J., Chen, Y., Lee, S. O., Chang, C. Tags: Cell Biology Source Type: research

EGFR mediates docetaxel resistance in human castration-resistant prostate cancer through the Akt-dependent expression of ABCB1 (MDR1).
In this study, we explored the mechanism of EGFR-mediated docetaxel resistance in PC. A series of stable docetaxel-resistant PC/DX sublines were established at our laboratory. The docetaxel IC50s of PC3 and PC/DX25 cells were 0.01 and 1.33 μM, respectively. Cellular resistance to docetaxel was significantly associated with increased EGFR and EGFR activation in PC/DX25. There was a dose-dependent increase in EGFR expression associated with the magnitude of docetaxel resistance. Expression of EGFR in PC/DX25 was higher than that in PC3, RWPE-1 and LNCaP cells. Similar results were also found in human PC tissues by immunohi...
Source: Archives of Toxicology - June 3, 2014 Category: Toxicology Authors: Hour TC, Chung SD, Kang WY, Lin YC, Chuang SJ, Huang AM, Wu WJ, Huang SP, Huang CY, Pu YS Tags: Arch Toxicol Source Type: research

Abstract 2623: PI3K/mTOR dual inhibitor PF-5212384 inhibits aberrant NF-kB activation and exhibits activity in combination with MEK inhibitor PD-325901 and docetaxel in human head and neck squamous cell carcinoma
In this study, we determined the effects of the novel PI3K-mTOR inhibitor PF-5212384 (PF-384) on molecular targets and HNSCC growth in preclinical models. PF-384 IC50s of 0.75nM-133nM were found in 12 HNSCC lines by XTT cell density assays and treatment resulted in increased sub-G0 cell death and G0/G1 phase blockade by DNA flow cytometry. PF-384 strongly inhibited direct targets of PI3K-mTOR, aberrant NF-kB transactivation and induced cytokines, but only partially inhibited MEK pathway targets. Transient siRNA knockdown of PIK3CA inhibited NF-kB activity, supporting PI3K-mTOR as an important driver and target for inhibiti...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Mohan, S., Broek, R. J. V., Saleh, A. D., Pierce, M. L., Coupar, J. F., Eytan, D. F., Chen, Z., Waes, C. V. Tags: Experimental and Molecular Therapeutics Source Type: research

Abstract 3310: N-cadherin promotes docetaxel resistance through upregulated TLR4 signaling in castration resistant prostate cancers
In this study, our objective is to determine the role of N-cadherin expression in chemoresistance and whether treatment with monoclonal antibodies restores chemosensitivity. Methods: Tissue microarrays of CRPC and high grade prostate cancer clinical samples were stained for TLR4. N-cadherin positive and negative cell lines were evaluated for sensitivity against docetaxel. N-cadherin and TLR4 were ectopically expressed in N-cadherin negative prostate cancer cells (LNCaP, VCaP). Docetaxel resistant cell lines (LNCaP-DocR and VCaP-DocR) were established through prolonged exposure to 10-20uM Docetaxel. For in vitro experiments...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Shimomura, T., Kono, E., Tran, C. P., Yamashiro, J., Lin, S., Lee, S. H.-K., Wainberg, Z. A., Reiter, R. E. Tags: Molecular and Cellular Biology Source Type: research