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Cardiac Alarmins as Residual Risk Markers of Atherosclerosis under Hypolipidemic Therapy
Int J Mol Sci. 2022 Sep 22;23(19):11174. doi: 10.3390/ijms231911174.ABSTRACTIncreased levels of low-density lipoproteins are the main risk factor in the initiation and progression of atherosclerosis. Although statin treatment can effectively lower these levels, there is still a residual risk of cardiovascular events. We hypothesize that a specific panel of stress-sensing molecules (alarmins) could indicate the persistence of silent atherosclerosis residual risk. New Zealand White rabbits were divided into: control group (C), a group that received a high-fat diet for twelve weeks (Au), and a treated hyperlipidemic group wit...
Source: Atherosclerosis - October 14, 2022 Category: Cardiology Authors: Viorel I Suica Elena Uyy Luminita Ivan Raluca M Boteanu Aurel Cerveanu-Hogas Rune Hansen Felicia Antohe Source Type: research

Therapeutic potential of topical administration of siRNAs against HIF-1 α for corneal neovascularization
In conclusion, the topical application of siRNA towards HIF-1α seems to be an effective and reliable method to stop neovascularization.PMID:35367249 | DOI:10.1016/j.exer.2022.109036
Source: Experimental Eye Research - April 3, 2022 Category: Opthalmology Authors: Assumpta Peral Jes ús Mateo Carmen O Dom ínguez-Godínez Gonzalo Carracedo Jose Antonio G ómez Almudena Crooke Jes ús Pintor Source Type: research

Nanog/NFATc1/Osterix signaling pathway-mediated promotion of bone formation at the tendon-bone interface after ACL reconstruction with De-BMSCs transplantation
CONCLUSIONS: De-BMSCs transplantation could promote bone formation at the tendon-bone interface after ACLR and improve the biomechanical strength of the reconstruction. The Nanog/NFATc1/Osterix signaling pathway mediated the enhanced osteogenic differentiation efficiency of De-BMSCs.PMID:34775995 | DOI:10.1186/s13287-021-02643-9
Source: Cell Research - November 15, 2021 Category: Cytology Authors: Kai Tie Jinghang Cai Jun Qin Hao Xiao Yangfan Shangguan Hui Wang Liaobin Chen Source Type: research

29PCharacterisation of growth hormone signal transduction in primary melanoma cell lines
ConclusionsIn this study, we have demonstrated GH stimulates signal transduction and promotes enhance of viability of primary melanoma cell lines, and that GHR blockade prevents this effect, indicating that blocking GHR signalling might be a useful strategy to treat melanoma. The next step is to understand whether GHR inhibition plays a role in regulating tumour growth in vivo.Editorial acknowledgementLi Family PhD Scholarship.Legal entity responsible for the studyPeter Shepherd.FundingHas not received any funding.DisclosureAll authors have declared no conflicts of interest.
Source: Annals of Oncology - October 1, 2019 Category: Cancer & Oncology Source Type: research

Corrigendum: Functional Urate-Associated Genetic Variants Influence Expression of lincRNAs LINC01229 and MAFTRR
Megan Leask1,2, Amy Dowdle1, Hamish Salvesen1, Ruth Topless3, Tayaza Fadason4, Wenhua Wei5, William Schierding2,4, Judith Marsman1,2, Jisha Antony1, Justin M. O'Sullivan2,4, Tony R. Merriman2,3* and Julia A. Horsfield1,2* 1Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand 2Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand 3Department of Biochemistry, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand 4Liggins Institute, The University of Auckland, Auckland, New Zealand 5Department of Wome...
Source: Frontiers in Genetics - April 23, 2019 Category: Genetics & Stem Cells Source Type: research

Beta2 adrenergic receptor silencing change intraocular pressure in New Zealand rabbits
ConclusionThe use of siRNA against the beta2 adrenergic receptors could provide an interesting therapeutic strategy for glaucoma treatment.ResumenObjetivoEl glaucoma consiste en un grupo de neuropatías ópticas progresivas caracterizadas por degeneración del nervio óptico y pérdida irreversible del campo visual. La elevación de la presión intraocular es el único factor de riesgo tratable probado, centrándose los productos comerciales para el tratamiento del glaucoma en la reducción de la presión intraocular. Estos fármacos pueden tener diversos efectos secundarios indeseados, lo cual invita a buscar nuevas estra...
Source: Journal of Optometry - July 10, 2018 Category: Opthalmology Source Type: research