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Condition: Pneumonia
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Total 107 results found since Jan 2013.
Synergistic regulation of microglia differentiation by CD93 and integrin β1 in the rat pneumococcal meningitis model
In conclusion, interaction between integrin β1 and CD93 promotes differentiation of microglia to the M1 phenotype, increases the release of pro-inflammatory factors, and leads to nervous system injury in pneumococcal meningitis.PMID:36336138 | DOI:10.1016/j.imlet.2022.11.001
Source: Immunology Letters - November 6, 2022 Category: Allergy & Immunology Authors: Nana Qiao Jinghui Zhang Ya Zhang Xinjie Liu Source Type: research
The RIPK3 Scaffold Regulates Lung Inflammation During Pseudomonas Aeruginosa Pneumonia
Am J Respir Cell Mol Biol. 2022 Sep 30. doi: 10.1165/rcmb.2021-0474OC. Online ahead of print.ABSTRACTRIPK3 kinase activity triggers cell death via necroptosis, while scaffold function supports protein binding and cytokine production. To determine if RIPK3 kinase or scaffold domains mediate pathology during Pseudomonas aeruginosa infection, control mice and those with deletion or mutation of RIPK3 and associated signaling partners were subjected to Pseudomonas pneumonia and followed for survival or sacrificed for biologic assays. Murine immune cells were studied in vitro for Pseudomonas-induced cytokine production and cell ...
Source: American Journal of Respiratory Cell and Molecular Biology - September 30, 2022 Category: Molecular Biology Authors: John D Lyons Pratyusha Mandal Shunsuke Otani Deena B Chihade Kristen F Easley David A Swift Eileen M Burd Zhe Liang Michael Koval Edward S Mocarski Craig M Coopersmith Source Type: research
1,25(OH) < sub > 2 < /sub > D < sub > 3 < /sub > promotes the elimination of Klebsiella pneumoniae infection by inducing autophagy through the VDR-ATG16L1 pathway
CONCLUSIONS: The present study demonstrated the protective features of 1,25(OH)2D3 in macrophages against Kp infection and may provide evidence for further exploration of its potential as an adjunctive therapy agent for the treatment of bacterial infections.PMID:36174418 | DOI:10.1016/j.intimp.2022.109266
Source: International Immunopharmacology - September 29, 2022 Category: Allergy & Immunology Authors: Jinhui Tang Liwen Gu Jieyu Luo Haihua Luo Qingli Zeng Yong Jiang Source Type: research
Molecular cloning, prokaryotic expression and the anti-inflammatory activity of porcine PRDX5
In this study, the full-length cDNA encoding porcine PRDX5 (pPRDX5) was cloned. Subsequently, using porcine alveolar macrophages (PAMs), the target cells of PRRSV infection in vivo, we found that the recombinant pPRDX5 protein inhibited inflammatory responses induced by tumor necrosis factor alpha (TNF-α) or porcine reproductive and respiratory syndrome virus (PRRSV), a virus causing severe interstitial pneumonia in pigs. By contrast, knockdown of endogenous pPRDX5 with specific siRNA enhanced inflammatory responses induced by TNF-α or PRRSV. We also demonstrated that the involvement of pPRDX5 in inflammation regulation ...
Source: Developmental and Comparative Immunology - August 19, 2022 Category: Allergy & Immunology Authors: Panpan Ma Yanrong Zhou Puxian Fang Wenting Ke Shaobo Xiao Liurong Fang Source Type: research
