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Condition: Pneumonia
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Total 107 results found since Jan 2013.
CLEC4A and CLEC12B C-type lectin receptors mediate interactions with < em > Pneumocystis < /em > cell wall components
Conclusion. The data presented here provide new members of the CLRs family recognizing Pneumocystis. Future studies using CLEC4A and/or CLEC12B deficient mice in the PCP mouse model should provide further insights into the host immunological response to Pneumocystis.PMID:37294293 | DOI:10.1099/jmm.0.001714
Source: Journal of Medical Microbiology - June 9, 2023 Category: Microbiology Authors: Theodore J Kottom Eva M Carmona Kyle Schaefbauer Andrew H Limper Source Type: research
VCAN activates JAK/STAT signaling pathway to promote the progression of LPS-induced acute pneumonia
ConclusionsVCAN knockdown alleviates lung injury of mice with pneumonia by inhibiting the JAK/STAT signaling pathway.
Source: Molecular and Cellular Toxicology - June 3, 2023 Category: Cytology Source Type: research
The CARDS toxin of Mycoplasma pneumoniae induces a positive feedback loop of type 1 immune response
ConclusionsOur findings suggest that CARDS toxin induces a type 1 immune response positive feedback loop during M. pneumoniae infection; this putative mechanism may be useful in future investigations of immune intervention approaches for M. pneumoniae pneumonia.
Source: Frontiers in Immunology - December 1, 2022 Category: Allergy & Immunology Source Type: research
Mechanisms and challenges of nanocarriers as non-viral vectors of therapeutic genes for enhanced pulmonary delivery
J Control Release. 2022 Nov 10:S0168-3659(22)00739-8. doi: 10.1016/j.jconrel.2022.10.061. Online ahead of print.ABSTRACTWith the rapid development of biopharmaceuticals and the outbreak of COVID-19, the world has ushered in a frenzy to develop gene therapy. Therefore, therapeutic genes have received enormous attention. However, due to the extreme instability and low intracellular gene expression of naked genes, specific vectors are required. Viral vectors are widely used attributed to their high transfection efficiency. However, due to the safety concerns of viral vectors, nanotechnology-based non-viral vectors have attrac...
Source: Cancer Control - November 13, 2022 Category: Cancer & Oncology Authors: Hezhi Wang Lu Qin Xin Zhang Jian Guan Shirui Mao Source Type: research
Synergistic regulation of microglia differentiation by CD93 and integrin β1 in the rat pneumococcal meningitis model
In conclusion, interaction between integrin β1 and CD93 promotes differentiation of microglia to the M1 phenotype, increases the release of pro-inflammatory factors, and leads to nervous system injury in pneumococcal meningitis.PMID:36336138 | DOI:10.1016/j.imlet.2022.11.001
Source: Immunology Letters - November 6, 2022 Category: Allergy & Immunology Authors: Nana Qiao Jinghui Zhang Ya Zhang Xinjie Liu Source Type: research
