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Astragalus improve aging bone marrow mesenchymal stem cells (BMSCs) vitality and osteogenesis through VD-FGF23-Klotho axis.
This study confirmed that astragalus could inhibit the aging of BMSCs and improve the osteogenesis ability by regulating the VD-FGF23-Klotho pathway. This study provided a certain research basis for the therapeutic of traditional Chinese medicine (TCM) on primary osteoporosis. PMID: 32355520 [PubMed]
Source: International Journal of Clinical and Experimental Pathology - May 3, 2020 Category: Pathology Authors: Pu X, Chai Y, Guan L, Li W, Gao J, Jiang Z, Li Q, Wu Y, Chen Y Tags: Int J Clin Exp Pathol Source Type: research

Propionate promotes vitamin D receptor expression via yes-associated protein in rats with short bowel syndrome.
In this study, we aimed to investigate the effect of propionate on the expression of the vitamin D receptor (VDR) in the small intestine of rats with SBS. Firstly, IEC-6 (intestinal epithelioid cell line No. 6) cells were incubated in vitro with 1 mM sodium propionate for 24 h. This resulted in a significant increase in the expression of VDR and yes-associated protein (YAP) compared with that in the control group. Transfection of IEC-6 cells with YAP siRNA significantly down-regulated the expression of VDR. By contrast, after incubating IEC-6 cells with lysophosphatidic acid, an agonist of YAP, upregulation of VDR and...
Source: Biochemical and Biophysical Research communications - January 11, 2020 Category: Biochemistry Authors: Lin H, Huang Y, Tian T, Wang P, Li Y Tags: Biochem Biophys Res Commun Source Type: research

Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Active vitamin D possesses beneficial effects on the interaction between muscle and bone.
In conclusion, these findings showed for the first time that active vitamin D plays important roles in myogenesis and muscle-induced osteoblastogenesis through OGN expression. Active vitamin D treatment may rescue the AGEs-induced sarcopenia as well as -suppressed osteoblastic differentiation via OGN expression in myoblasts. PMID: 24924628 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - June 9, 2014 Category: Biochemistry Authors: Tanaka KI, Kanazawa I, Yamaguchi T, Yano S, Kaji H, Sugimoto T Tags: Biochem Biophys Res Commun Source Type: research