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Specialty: Allergy & Immunology
Condition: Osteoarthritis
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Total 27 results found since Jan 2013.
ASIC1a-CMPK2-mediated M1 macrophage polarization exacerbates chondrocyte senescence in osteoarthritis through IL-18
CONCLUSION: These results demonstrate a novel pathogenic process that results in OA cartilage damage, in which M1 macrophage derived IL-18 induces articular chondrocytes senescence. Further, the ASIC1a-CMPK2 axis was shown to positively regulate M1 macrophage polarization. Hence, ASIC1a is a promising treatment target for M1 macrophage-mediated diseases, such as OA.PMID:37660594 | DOI:10.1016/j.intimp.2023.110878
Source: International Immunopharmacology - September 3, 2023 Category: Allergy & Immunology Authors: Lei Dong Yingjie Zhao Cheng Sun Ziwei Ou Yang Fan Chen Weirong Hu Hailin Zhang Yan Wang Rendi Zhu Yuanzhi Cheng Yong Chen Shufang Li Ke Wang Changhai Ding Renpeng Zhou Wei Hu Source Type: research
Stevioside protects primary articular chondrocytes against IL-1 β-induced inflammation and catabolism by targeting integrin
Int Immunopharmacol. 2023 May 9;119:110261. doi: 10.1016/j.intimp.2023.110261. Online ahead of print.ABSTRACTOsteoarthritis (OA) is a common, progressive, and chronic disorder of the joints that is characterized by the inflammation and degradation of articular cartilage and is known to significantly impair quality of daily life. Stevioside (SVS) is a natural diterpenoid glycoside that has anti-inflammatory benefits. Hence, in the current research, it was hypothesized that SVS might exert anti-inflammatory effects on articular chondrocytes and alleviate cartilage degradation in mice with OA. The expression of inflammatory c...
Source: International Immunopharmacology - May 11, 2023 Category: Allergy & Immunology Authors: Junlai Wan Ziqing Zhu Zhiyi He Hua Wu Anmin Chen Wentao Zhu Peng Cheng Source Type: research
CX-4945 inhibits fibroblast-like synoviocytes functions through the CK2-p53 axis to reduce rheumatoid arthritis disease severity
Int Immunopharmacol. 2023 Apr 13;119:110163. doi: 10.1016/j.intimp.2023.110163. Online ahead of print.ABSTRACTFibroblast-like synoviocytes (FLS) mediate many pathological processes in rheumatoid arthritis (RA), including pannus formation, bone erosion, and inflammation. RA FLS have unique aggressive phenotypes and exhibit several tumor cell-like characteristics, including hyperproliferation, excessive migration and invasion. Casein kinase 2 (CK2) is reportedly overexpressed in numerous tumor types, and targeted inhibition of CK2 has therapeutic benefits for tumors. However, the expression level of CK2 and its functions in ...
Source: International Immunopharmacology - April 15, 2023 Category: Allergy & Immunology Authors: Yanping Luo Yunxuan Lei Xin Guo Dehao Zhu Haiyang Zhang Zizhen Guo Zichong Xu Hanqing Zhao Yebin Xi Xiaochun Peng Lianbo Xiao Zhaojun Wang Xiaoyin Niu Guangjie Chen Source Type: research
Indole-3-aldehyde alleviates chondrocytes inflammation through the AhR-NF- κB signalling pathway
CONCLUSIONS: 3-IAld reduced inflammation through the AhR-NF-κB signalling pathway in IL-1β-induced chondrocytes, which is expected to provide a new therapeutic strategy for OA.PMID:36252481 | DOI:10.1016/j.intimp.2022.109314
Source: International Immunopharmacology - October 17, 2022 Category: Allergy & Immunology Authors: Huangming Zhuang Bin Li Ting Xie Changgeng Xu Xunshan Ren Fuze Jiang Tianrun Lei Panghu Zhou Source Type: research
Circ_0128846/miR-140-3p/JAK2 Network in Osteoarthritis Development
This study attempted to confirm the role of a novel circRNA circ_0128846 during osteoarthritis (OA) progression. Tissues and chondrocytes were isolated from OA patients. Overexpression and knockdown of target genes were generated using cell transfection and siRNA interference. Expression levels of genes were measured by qRT-PCR, Western blot, and immunohistochemistry, respectively. The interactions among circ_0128846, miR-140-3p, and JAK2 were verified by bioinformatics prediction, a dual-luciferase reporter assay, and RNA immunoprecipitation assay. The role of circ_0128846 in vivo was confirmed by the construction of expe...
Source: Immunological Investigations - September 21, 2021 Category: Allergy & Immunology Authors: Hongjun Li Zhongyu Liu Xiaoyun Guo Mei Zhang Source Type: research
Zinc finger protein A20 regulates the development and progression of osteoarthritis by affecting the activity of NF- κB p65
CONCLUSION: A20 was reduced in OA cartilage samples, and its overexpression, by suppressing the activity of NF-κB p65, could improve IL-1β-induced chondrocyte degradation and apoptosis in vitro, as well as mitigate the inflammation in OA mice.PMID:34463587 | DOI:10.1080/08923973.2021.1970764
Source: Immunopharmacology and Immunotoxicology - August 31, 2021 Category: Allergy & Immunology Authors: Shu-Bei Cui Tao-Xia Wang Zhen-Wu Liu Ji-Ying Yan Kai Zhang Source Type: research
Circular RNA circZNF652 is overexpressed in osteoarthritis and positively regulates LPS-induced apoptosis of chondrocytes by upregulating PTEN
This study was carried to explore the involvement of circZNF652 in OA. RT-qPCR was performed to analyse the expression of circZNF652 and PTEN mRNA in synovial fluid samples from 60 OA patients and 60 healthy controls. Correlations between circZNF652 and PTEN mRNA were analysed by Pearson's correlation coefficient. Overexpression and siRNA silencing of circZNF652 were achieved in chondrocytes, followed by performing RT-qPCR and Western blot to analyse the expression of PTEN. The role of circZNF652 and PTEN in regulating the apoptosis of chondrocytes induced by LPS was analysed by cell apoptosis assay. We found that circZNF6...
Source: Autoimmunity - July 15, 2021 Category: Allergy & Immunology Authors: Xuefeng Yuan Yingchi Zhang Cong Cai Chaoxu Liu Jie Xie Chengla Yi Source Type: research
