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MicroRNA ‑186‑5p downregulation inhibits osteoarthritis development by targeting MAPK1.
In conclusion, the present results indicated that miR‑186‑5p could attenuate IL‑1β‑induced chondrocyte inflammation damage by increasing MAPK1 expression, suggesting that miR‑186‑5p may be used as a potential therapeutic target for OA. PMID: 33537828 [PubMed - in process]
Source: Molecular Medicine - February 6, 2021 Category: Molecular Biology Authors: Li Q, Wu M, Fang G, Li K, Cui W, Li L, Li X, Wang J, Cang Y Tags: Mol Med Rep Source Type: research

MicroRNA ‑186‑5p downregulation inhibits osteoarthritis development by targeting MAPK1
In conclusion, the present results indicated that miR‑186‑5p could attenuate IL‑1β‑induced chondrocyte inflammation damage by increasing MAPK1 expression, suggesting that miR‑186‑5p may be used as a potential therapeutic target for OA.PMID:33537828 | DOI:10.3892/mmr.2021.11892
Source: Molecular Medicine Reports - February 4, 2021 Category: Molecular Biology Authors: Qing Li Mingjie Wu Guofang Fang Kuangwen Li Wengang Cui Liang Li Xia Li Junsheng Wang Yanhong Cang Source Type: research

Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling
In this study, we aimed to investigate the potential anti-proliferative and pro-apoptotic activities of SNG in a panel of MM cell lines (U266, IM9, MM1S, and RPMI-8226). SNG treatment of MM cells resulted in a dose-dependent decrease in cell viability through mitochondrial membrane potential loss and activation of caspase 3, 9, and cleavage of PARP. Pre-treatment of MM cells with a universal caspase inhibitor, Z-VAD-FMK, prevented SNG mediated loss of cell viability, apoptosis, and caspase activation, confirming that SNG-mediated apoptosis is caspase-dependent. The SNG-mediated apoptosis appears to be resulted from suppres...
Source: Frontiers in Oncology - April 16, 2019 Category: Cancer & Oncology Source Type: research