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Specialty: Respiratory Medicine
Condition: Hypertension
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Total 70 results found since Jan 2013.
Contribution of TRPC channels in human and experimental pulmonary arterial hypertension
Am J Physiol Lung Cell Mol Physiol. 2023 Jun 27. doi: 10.1152/ajplung.00011.2023. Online ahead of print.ABSTRACTPulmonary arterial hypertension (PAH) is due to progressive distal pulmonary artery (PA) obstruction leading to right ventricular hypertrophy and failure. Exacerbated store-operated Ca2+ entry (SOCE) contributes to PAH pathogenesis, mediating human PA smooth muscle cells (hPASMCs) abnormalities. The transient receptor potential canonical channels (TRPC family) are Ca2+-permeable channels contributing to SOCE in different cell types, including PASMCs. However, the properties, signaling pathways, and contribution t...
Source: Am J Physiol Lung Ce... - June 27, 2023 Category: Respiratory Medicine Authors: Bastien Masson Ana ïs Saint-Martin Willer Mary Dutheil Lucille Penalva H élène Le Ribeuz Kristelle El Jekmek Yann Ruchon Sylvia Cohen-Kaminsky Jessica Sabourin Marc Humbert Olaf Mercier David Montani V éronique Capuano Fabrice Antigny Source Type: research
IL-11 increases levels and activates circulating fibrocytes in different pulmonary hypertension animal models.
In conclusion, IL-11 promotes an increase of circulating fibrocytes, their adhesion to HPAECs and phenotypic switching to myofibroblast.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Roger, I., Milara, J., Montero, P., Belhadj, N., Cortijo, J. Tags: 13.01 - Pulmonary hypertension Source Type: research
COX2 expression is downregulated in a shear stress magnitude-dependent manner in BMPR2-silenced HPAECs: implications for prostacyclin deficiency in PAH
Conclusion: BMPR2 loss may disrupt the flow-driven production of COX2 in HPAECs, which may be an underlying mechanism of endothelial dysfunction in PAH.
Source: European Respiratory Journal - December 1, 2022 Category: Respiratory Medicine Authors: Mahomed, A., Burke-Gaffney, A., Ghazaly, M., Naser, J., Toe, Q., Quinlan, G., Wort, S. J. Tags: 13.01 - Pulmonary hypertension Source Type: research
DNA-PKcs participated in hypoxic pulmonary hypertension
CONCLUSIONS: Our study indicated the potential mechanism of DNA-PKcs in the development of HPH. It might provide insights into new therapeutic targets for pulmonary vascular remodeling and pulmonary hypertension.PMID:36114572 | DOI:10.1186/s12931-022-02171-x
Source: Respiratory Care - September 16, 2022 Category: Respiratory Medicine Authors: Ying-Ying Liu Wei-Yun Zhang Meng-Lan Zhang Yu-Ji Wang Xi-Yan Ma Jung-Hong Jiang Ran Wang Da-Xiong Zeng Source Type: research
Y-Chromosome Gene, < em > Uty < /em > , Protects Against Pulmonary Hypertension by Reducing Proinflammatory Chemokines
CONCLUSIONS: Uty, is protective against PH. Reduction of Uty expression results in increased expression of proinflammatory chemokines CXCL9 and CXCL10 which trigger endothelial cell death and PH. Inhibition of Cxcl9 and Cxcl10 rescues PH development in multiple experimental models.PMID:35504005 | DOI:10.1164/rccm.202110-2309OC
Source: Respiratory Care - May 3, 2022 Category: Respiratory Medicine Authors: Christine M Cunningham Min Li Gregoire Ruffenach Mitali Doshi Laila Aryan Jason Hong John Park Haley Hrncir Lejla Medzikovic Soban Umar Arthur P Arnold Mansoureh Eghbali Source Type: research
Mechanosensitive channel Piezo1 is required for pulmonary artery smooth muscle cell proliferation
Am J Physiol Lung Cell Mol Physiol. 2022 Mar 23. doi: 10.1152/ajplung.00447.2021. Online ahead of print.ABSTRACTConcentric pulmonary vascular wall thickening due partially to increased PASMC proliferation contributes to elevating PVR in patients with pulmonary hypertension (PH). While pulmonary vasoconstriction may be an early contributor to increasing PVR, the transition of contractile PASMCs to proliferative PASMCs may play an important role in the development and progression of pulmonary vascular remodeling in PH. A rise in cytosolic Ca2+ concentration ([Ca2+]cyt) is a trigger for PASMC contraction and proliferation. He...
Source: Am J Physiol Lung Ce... - March 23, 2022 Category: Respiratory Medicine Authors: Jiyuan Chen Marisela Rodriguez Jinrui Miao Jing Liao Pritesh Prakash Jain Manjia Zhao Tengteng Zhao Aleksandra Babicheva Ziyi Wang Sophia Parmisano Ryan Powers Moreen Matti Cole Paquin Zahra Soroureddin John Y-J Shyy Patricia A Thistlethwaite Ayako Makino Source Type: research
