• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Microvascular Adaptations to Exercise: Protective Effect of PGC-1 Alpha.
CONCLUSIONS: These findings suggest that the microvascular adaptations to exercise training, and the exercise-induced protection against acute vascular stress in overweight/obese subjects, are mediated by PGC-1α. PMID: 29140431 [PubMed - as supplied by publisher]
Source: American Journal of Hypertension - November 11, 2017 Category: Cardiology Authors: Kadlec AO, Barnes C, Durand MJ, Gutterman DD Tags: Am J Hypertens Source Type: research

Shear Stress-Induced Mitochondrial Biogenesis Decreases the Release of Microparticles from Endothelial Cells.
Abstract The concept of enhancing structural integrity of mitochondria has emerged as a novel therapeutic option for cardiovascular disease. Flow-induced increase in laminar shear stress is a potent physiological stimulant associated with exercise which exerts atheroprotective effects in the vasculature. However, the effect of laminar shear stress on mitochondrial remodeling within the vascular endothelium and its related functional consequences remain largely unknown. Using in vitro and in vivo complementary studies, here, we report that aerobic exercise alleviates the release of endothelial microparticles in pre...
Source: American Journal of Physiology. Heart and Circulatory Physiology - May 29, 2015 Category: Physiology Authors: Kim JS, Kim B, Lee H, Thakkar S, Babbitt DM, Eguchi S, Brown MD, Park JY Tags: Am J Physiol Heart Circ Physiol Source Type: research

Improvement of vascular insulin sensitivity by downregulation of GRK2 mediates exercise-induced alleviation of hypertension in spontaneously hypertensive rats.
Abstract Exercise training lowers blood pressure and is a recommended nonpharmacological strategy and useful adjunctive therapy for hypertensive patients. Studies demonstrate that physical activity attenuates progression of hypertension. However, underlying mechanisms remain elusive. Vascular insulin resistance and endothelial dysfunction plays a critical role in the development of hypertension. The present study investigated whether long-term physical exercise starting during the prehypertensive period prevents the development of hypertension via improving vascular insulin sensitivity. Young (4-week-old) prehyper...
Source: American Journal of Physiology. Heart and Circulatory Physiology - August 2, 2013 Category: Physiology Authors: Xing W, Li Y, Zhang H, Mi C, Hou Z, Quon MJ, Gao F Tags: Am J Physiol Heart Circ Physiol Source Type: research