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Cyclo-(Phe-Tyr) as a novel cyclic dipeptide compound alleviated ischemic stroke reperfusion brain injury via JUNB/JNK/NF- κB and SOX5/PI3K/AKT pathways
Pharmacol Res. 2022 Apr 25:106230. doi: 10.1016/j.phrs.2022.106230. Online ahead of print.ABSTRACTIschemic stroke reperfusion (IR) can cause adverse reactions including apoptosis, oxidative stress, and inflammation, but the existing therapeutic strategies have been limited. Moreover, the regulation of microglia plays an important role in brain injury after reperfusion. Hence, it is imperative to find new and effective drugs for modulating microglia to treat IR brain injury. Cyclic peptide compound cyclo-(Phe-Tyr) (Sparganin C, SC) is a compound isolated from Sparganii Rhizoma. However, the protective effects of SC on the c...
Source: Cell Research - April 28, 2022 Category: Cytology Authors: Jiale Cai Jiayin Liang Yutong Zhang Lin Shen Huiting Lin Tao Hu Sikai Zhan Meixia Xie Shengwang Liang Minghua Xian Shumei Wang Source Type: research

Inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia-induced blood-brain barrier injury through the Wnt/ β-catenin signalling pathway
CONCLUSION: This study suggests that inhibition of the immunoproteasome LMP2 ameliorates ischemia/hypoxia-induced BBB injury, and that the molecular mechanism involves the immunoproteasome-regulated activation of the Wnt/β-catenin signalling pathway under ischemic conditions.PMID:34857032 | DOI:10.1186/s40779-021-00356-x
Source: Cell Research - December 3, 2021 Category: Cytology Authors: Xing-Yong Chen Shao-Fen Wan Nan-Nan Yao Ze-Jing Lin Yan-Guang Mao Xiao-Hua Yu Yin-Zhou Wang Source Type: research

MiR-499a prevents astrocytes mediated inflammation in ischemic stroke by targeting PTEN
CONCLUSIONS: Taken together, our findings indicate miR-499a as an important factor to prevent inflammatory response and suggest miR-499a as a new molecule for the treatment of IS. The present study also demonstrated the relationship between miR-499a and PTEN, with PTEN as a downstream signaling mediator of miR-499a in the inflammatory response of astrocytes induced by IS.PMID:34632168 | PMC:PMC8488463 | DOI:10.1016/j.ncrna.2021.09.002
Source: Cell Research - October 11, 2021 Category: Cytology Authors: Xiaoxiang Guan Yiwei Zhang Ilgiz Gareev Ozal Beylerli Xinyuan Li Guitian Lu Lin Lv Xin Hai Source Type: research

Expression of Long Non-coding RNA RGD1566344 in the Brain Cortex of Male Mice After Focal Cerebral Ischemia-Reperfusion and the Neuroprotective Effect of a Non-coding RNA RGD1566344 Inhibitor.
In this study, we found that RGD1566344 levels were elevated in the ischemic infarct and penumbra regions 12 h after middle cerebral artery occlusion/reperfusion (MCAO/R) in male mice and in PC12 cells with oxygen glucose deprivation/reperfusion (OGD/R). The inhibition of RGD1566344 by small interference RNA (siRNA) significantly alleviated apoptosis in OGD/R PC12 cells. In cell transfection, quantitative real-time PCR, and Western blot experiments, we demonstrated the possible interaction of non-POU domain-containing octamer-binding protein (NONO) with RGD1566344. The NONO level in OGD/R PC12 cells was obviously increase...
Source: Cellular and Molecular Neurobiology - May 17, 2020 Category: Cytology Authors: Zhang J, Rui Y, Gao M, Wang L, Yan BC Tags: Cell Mol Neurobiol Source Type: research

Berberine Facilitates Angiogenesis Against Ischemic Stroke Through Modulating Microglial Polarization via AMPK Signaling.
In conclusion, BBR treatment improves functional recovery and promotes angiogenesis following tMCAO via AMPK-dependent microglial M2 polarization. PMID: 31020571 [PubMed - as supplied by publisher]
Source: Cellular and Molecular Neurobiology - April 23, 2019 Category: Cytology Authors: Zhu J, Cao D, Guo C, Liu M, Tao Y, Zhou J, Wang F, Zhao Y, Wei J, Zhang Y, Fang W, Li Y Tags: Cell Mol Neurobiol Source Type: research

Upregulation of NOX2 and NOX4 Mediated by TGF- β Signaling Pathway Exacerbates Cerebral Ischemia/Reperfusion Oxidative Stress Injury
Conclusions: Our studies demonstrated that TGF- β signaling activation is involved in the regulation of NOX2/NOX4 expression and exacerbates cerebral I/R injury.Cell Physiol Biochem 2018;46:2103 –2113
Source: Cellular Physiology and Biochemistry - May 3, 2018 Category: Cytology Source Type: research

IL-8 enhances angiogenesis of human bone marrow mesenchymal stem cells by increasing vascular endothelial growth factor.
In conclusion, IL-8 stimulates VEGF production in hBM-MSCs in part via the PI3K/Akt and MAPK/ERK signal transduction pathways and that administration of IL-8-treated hBM-MSCs increases angiogenesis after stroke. This approach may be used to optimize MSC-based therapies for numerous diseases including stroke, myocardial ischemia, and spinal cord injury. PMID: 24797366 [PubMed - as supplied by publisher]
Source: Cell Biology International - May 5, 2014 Category: Cytology Authors: Hou Y, Ryu CH, Jun JA, Kim SM, Jeong CH, Jeun SS Tags: Cell Biol Int Source Type: research