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Globular adiponectin protects hepatocytes against intermittent hypoxia-induced injury via Pink1/Parkin-mediated mitophagy induction
ConclusiongAPN alleviated IH-induced mitochondrial injury and hepatocyte apoptosis by upregulating Pink1/Parkin-mediated mitophagy.
Source: Sleep and Breathing - October 26, 2021 Category: Respiratory Medicine Source Type: research

Targeting progesterone receptors in newborn males and females: from the animal model to a new perspective for the treatment of apnea of prematurity?
We present original data showing that in newborn rats, selective nPR or mPR agonists are more efficient to reduce apnea frequency at postnatal days 12 than at postnatal day 1, and appear more efficient in males than in females. Furthermore, new results obtained by using intra-cisternal injection of specific siRNA targeting mPRα, mPRβ (two mPR with high brain expression) or nPR suggest that mPRβ regulates the stability of the breathing pattern in males, while effects of nPR appears in females. While several important questions remain to be addressed before a safe clinical use could be proposed, these results highlight th...
Source: Respiratory Physiology and Neurobiology - March 16, 2019 Category: Respiratory Medicine Source Type: research

Increased CTGF expression of circulating fibrocytes in asthmatic patients with severe OSA - the role of HIF-1a and HDAC7
Conclusion: Severe OSA related hypoxia increases CTGF expression in circulating fibrocytes via activation of HIF-1α that requires HDAC7 nuclear co-transprotation. HDAC7 may serve a therapeutic target for airway remodeling in asthmatics with severe OSA.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Wang, T.-Y., Lo, Y.-L., Wang, C.-H., Kuo, H.-P. Tags: Airway Cell Biology and Immunopathology Source Type: research

The role of hypoxia and the circadian rhythm in sleep apnoea
Conclusion: Hypoxia in OSA causes an increase of HIF-1α which in turn disrupts the circadian rhythm in vitro. This pathway might be a potential target in tackling sleep apnoea.
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Jaspers, T., Morrell, M., Simonds, A., Adcock, I., Durham, A. Tags: 4.2 Sleep and Control of Breathing Source Type: research

Chronic Intermittent Hypoxia Induces Atherosclerosis via Activation of Adipose Angiopoietin-like 4.
CONCLUSIONS: Hypoxia inducible factor 1-mediated increase in adipose Angptl4 and ensuing lipoprotein lipase inactivation may contribute to atherosclerosis in patients with sleep apnea. PMID: 23328524 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory and Critical Care Medicine - January 17, 2013 Category: Respiratory Medicine Authors: Drager LF, Yao Q, Hernandez KL, Shin MK, Bevans-Fonti S, Gay J, Sussan TE, Jun JC, Myers AC, Olivecrona G, Schwartz AR, Halberg N, Scherer PE, Semenza GL, Powell DR, Polotsky VY Tags: Am J Respir Crit Care Med Source Type: research