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Cutaneous Deficiency of Filaggrin and STAT3 Exacerbates Vaccinia Disease < i > In Vivo < /i >
ConclusionsOur findings may point to a novel role for filaggrin in early antiviral responses in skin. In wounded skin with underlying barrier defects, chronically elevated activin A levels may contribute to skin remodeling and cutaneous pathogen persistence. Inhibition of ALK5/TGF βR1 signaling may provide a novel co-therapeutic approach, together with VIG, to limit cutaneous spread of vaccinia.
Source: PLoS One - January 11, 2017 Category: Biomedical Science Authors: Yong He Source Type: research

Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis
Topical application of coal tar is one of the oldest therapies for atopic dermatitis (AD), a T helper 2 (Th2) lymphocyte–mediated skin disease associated with loss-of-function mutations in the skin barrier gene, filaggrin (FLG). Despite its longstanding clinical use and efficacy, the molecular mechanism of coal tar therapy is unknown. Using organotypic skin models with primary keratinocytes from AD patients and controls, we found that coal tar activated the aryl hydrocarbon receptor (AHR), resulting in induction of epidermal differentiation. AHR knockdown by siRNA completely abrogated this effect. Coal tar restored ...
Source: Journal of Clinical Investigation - January 26, 2013 Category: Biomedical Science Authors: Ellen H. van den Bogaard, Judith G.M. Bergboer, Mieke Vonk-Bergers, Ivonne M.J.J. van Vlijmen-Willems, Stanleyson V. Hato, Pieter G.M. van der Valk, Jens Michael Schröder, Irma Joosten, Patrick L.J.M. Zeeuwen, Joost Schalkwijk Source Type: research