• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Regulation of NcRNA-protein binding in diabetic foot
In this study, we explored the mechanism and new progress of ncRNA-protein binding in DF, which can provide help and guidance for the application of ncRNA in the early diagnosis and potential targeted intervention of DFU.PMID:36753956 | DOI:10.1016/j.biopha.2023.114361
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - February 8, 2023 Category: Drugs & Pharmacology Authors: Yujia Zhang Jing Zhang Zhou Xu Deju Zhang Panpan Xia Jitao Ling Xiaoyi Tang Xiao Liu Rui Xuan Meiying Zhang Jianping Liu Peng Yu Source Type: research

Glycyrrhizic acid promotes sciatic nerves recovery in type 1 diabetic rats and protects Schwann cells from high glucose-induced cytotoxicity
J Biomed Res. 2022 May 15:1-14. doi: 10.7555/JBR.36.20210198. Online ahead of print.ABSTRACTThe present study aims to investigate the therapeutic effect and mechanism of glycyrrhizic acid (GA) in diabetic peripheral neuropathy (DPN). GA significantly mitigated nerve conduction velocity (NCV) deficit and morphological abnormality and reduced high-mobility group box-1 (HMGB1) expression in the sciatic nerves of diabetic rats independent of blood glucose and body weight. Notably, GA alleviated the increase of HMGB1 and the decrease of cell viability in high glucose-stimulated RSC96 cells. Furthermore, GA obviously reduced the...
Source: Cell Research - May 17, 2022 Category: Cytology Authors: Min Shi Xiangcheng Zhang Ridong Zhang Hong Zhang Dalong Zhu Xiao Han Source Type: research

Identification of lncRNA and mRNA expression profiles in dorsal root ganglion in rats with cancer-induced bone pain
CONCLUSION: LncRNA played important roles in regulation of CIBP or mRNA expression in peripheral neuropathy in CIBP. These alterd mRNAs and lncRNAs might be potential therapeutic targets for the treatment of CIBP.PMID:34364296 | DOI:10.1016/j.bbrc.2021.07.063
Source: Cell Research - August 7, 2021 Category: Cytology Authors: Jinrong Wei Qianshu Dou Futing Ba Guang-Yin Xu Guo-Qin Jiang Source Type: research

Duloxetine suppresses BMP-4-induced release of osteoprotegerin via inhibition of the SMAD signaling pathway in osteoblasts
Biochem Cell Biol. 2021 Mar 1. doi: 10.1139/bcb-2020-0347. Online ahead of print.ABSTRACTDuloxetine, a selective serotonin-norepinephrine reuptake inhibitor, is currently recommended to use in the treatment of chronic painful disorders such as fibromyalgia, chronic musculoskeletal pain and diabetic peripheral neuropathy. We previously demonstrated that bone morphogenetic protein-4 (BMP-4) stimulates osteoprotegerin (OPG) production in osteoblast-like MC3T3-E1 cells, and that p70 S6 kinase positively regulates the OPG synthesis. The present study is aimed to investigate the effect of duloxetine on BMP-4-stimulated OPG synth...
Source: Biochemistry and Cell Biology - March 1, 2021 Category: Biochemistry Authors: Junko Tachi Takashi Onuma Shinobu Yamaguchi Woo Kim Tomoyuki Hioki Rie Matsushima-Nishiwaki Kumiko Tanabe Haruhiko Tokuda Osamu Kozawa Hiroki Iida Source Type: research

Lipin 1 deficiency causes adult-onset myasthenia with motor neuron dysfunction in humans and neuromuscular junction defects in zebrafish
Conclusions: These findings pointed out that the compound heterozygous mutations in human LPIN1 caused adult-onset syndromic myasthenia with peripheral neuropathy. Moreover, zebrafish could be used to model the neuromuscular phenotypes due to the lipin 1 deficiency, where a novel pathological role of over-activated Notch signaling was discovered and further confirmed in mammalian cell lines.
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Shuxian Lu, Zhaojie Lyu, Zhihao Wang, Yao Kou, Cong Liu, Shengyue Li, Mengyan Hu, Hongjie Zhu, Wenxing Wang, Ce Zhang, Yung-Shu Kuan, Yi-Wen Liu, Jianming Chen, Jing Tian Tags: Research Paper Source Type: research

AIF knockdown induce apoptosis and mitochondrial dysfunction in cochlear spiral ganglion neurons in  vitro.
AIF knockdown induce apoptosis and mitochondrial dysfunction in cochlear spiral ganglion neurons in vitro. Mol Med Rep. 2020 Jan 31;: Authors: Zong L, Zhao J, Wu W, Wang J, Huang D, Liu M Abstract The underlying mechanism involved in auditory neuropathy spectrum disorder (ANSD) remains largely unclear. It has been previously reported that mutations in the apoptosis‑inducing factor (AIF) gene are associated with auditory neuropathy and delayed peripheral neuropathy, which can eventually cause ANSD. In the present study, the regulatory effects of AIF knockdown on the cellular functions of spiral gangl...
Source: Molecular Medicine Reports - April 24, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Pages: 1  2  3